Since the outbreak of COVID-19, the domestic air transport as well as tourism and culture industries have suffered significant economic loss due to restrictions on movement between countries. This study investigates loss on production outputs in the domestic tourism/culture and related industries due to the decrease in inbound tourists caused by COVID-19, and analyzes pervasive effects on the entire industry. The amount of losses in the tourism/culture and related industries was estimated based on the per capita expenditure of inbound tourists and changes in the number of foreign tourists after the outbreak. Results show that loss in sales volume was significant in the order of the shopping, air transport, accommodation, and food service industry. Based on the results, scenarios were made by deriving estimated economic losses from 2020 to 2023 (4-year scenario period) in the nine tourism/cultural and related industries. The scenarios were incorporated in the input-output analysis to analyze ripple effects on the whole industry in terms of production, value-added, and employment. Final results indicate that the decline in sales of the tourism/cultural and related industry due to COVID-19 will result in a decrease of 94,071.7 billion KRW in industry output, a decrease of 39,064.8 billion KRW in value-added, and a decrease of 71,557 jobs over the 4-year scenario period. In the case of the culture/arts and entertainment industry, which is the industry of our main attention, would have a loss of 612.1 billion KRW over the four years. This will have a negative effect of 191.9 billion KRW to other industries. Contribution of this study lies in quantifying specific amount of damage caused by COVID-19 on the tourism and culture industry and related industries.