In the late 18th century, Britain began selling opium to China through East India Company, gradually opening the door to China's giant market, in the late 19th century, through port trade under the unequal treaty, gradually bringing many Western products into China and creating a distinctive design that fused Western brand concept with Chinese aesthetic language to attract consumers from other cultures. Following the period background, the paper was divided into three periods of comparative study. It is divided into the period of the Republic of China (1912-1949), From the founding of the People's Republic of China to the beginning of reform and opening up (1949-1978), and the early Reform and Opening (1978-1900). Through the comparative study of the three-stage product advertisement, the characteristics of print advertisement and the design law and the historical cause behind it can be analyzed and well recognized. The results also allow the Chinese to fully reproduce the true state and change of life for 78 years. The design culture of the period can also be understood more comprehensively. You can use the design law and recreate the design with a special New-tro style.