Doronicum Hookeri of family Asteraceae is an important medicinal drug distributed in Himalayas at Lachen and Tungu, Sikkim, Nepal, Bhutan, Tibet between 12,000 to 14,000 ft. Its roots are widely used as folk medicine and are commonly known as “Darunaj-aqrabi” in Unani and as “Leopard’s bane” in English. Roots are traditionally used as a constituent of, act as a stomachic and dissolves trapped gases. Antibacterial and antifungal activities of D. hookeri roots have been previously reported. The methanolic extract of root part possessed higher phenolic content and thus higher free radical scavenging and reducing activities. The methanolic extract of this plant showed scavenging and antioxidant activities in DPPH (2,2- diphenyl-1-picryhydrazy) radical scavenging assay.
Ayurveda is gradually getting more acceptances in the world. The fact is visible through increasing number of Ayurveda articles in leading medical journals and also through the chapters on Ayurveda in various biomedical publications. Although the world is now looking up at the authentic information about Ayurveda, the status of Ayurveda publishing in India is not very promising. Poor workmanship while preparing the articles on Ayurveda and non professional approaches in publishing are the reasons of the poor show and this requires to be seriously taken up.
The Tridosha theory, which is the cornerstone of Ayurvedic physiology governs all the functions of human body and mind. Tridosha are responsible in determining one’s Prakriti and their functional status may vary in both gender of different Prakriti. No research work is available to assess the functions of Dosha by objective parameters. Therefore, this study was planned to find out the variation in functional status of different types of Pitta, using certain objective parameters, in 201 young healthy volunteers of both gender belonging to different Prakriti. Serum level of triglycerides, cholesterol, total protein and glucose level were estimated for Pachaka Pitta and hemoglobin concentration for Ranjaka Pitta, visual acuity for Alochaka Pitta, memory and reaction time for Sadhaka Pitta and RGB value for Bhrajaka Pitta were measured .Except the functioning of Bhrajaka Pitta, variation in functional status of all type of Pitta was not the same in different Prakriti of both gender. However these findings were not significant which may have occurred due to small sample size and homogenous population. Thus we propose the consideration of sex differences while planning and evaluating the studies that are based on Prakriti.
Fasad i.e. venesection is an old classical method of treatment in the Unani system of medicine. Fasad is Arabic word which means “to open”. In the process, complete evacuation which drains out blood and dominating humours mixed with blood from veins. Fasad is carried out when the kamiyat (quantity) of the blood is excess in the body and patient is either exposed to the risk of developing a disease or has actually developed one. In classical literature of Unani system of medicine, physicians wrote a lot about this procedure. The details of venesection is mentioned in the given paper on the basis of classical literature including history, indications, types, amount of blood to be venesected, time, person, procedure, complications and special focus has been made on the number of vessels to be venesected and their benefits with respected to disease and condition.
Inflammation has been linked to various diseases. Especially, fatigue is a frequent symptom in several inflammatory disorders. Therefore, blocking inflammatory process is effective in fatigue. We investigated whether Denmark porcine placenta (DPP) alleviates fatigue by inhibiting inflammatory reaction using forced swimming test (FST) animal model and RAW264.7 cells. In FST-induced fatigue animal model, the mice which received the DPP for 21 days showed decreases of interleukin (IL)-1β and IL-6 serum levels. Furthermore, our data revealed that lipopolysaccharide (LPS)-induced IL-1β, IL-6, and tumor necrosis factor-α secretion were markedly inhibited by DPP in RAW264.7 cells without inducing cytotoxicity. LPS-enhanced nitric oxide secretion and inducible nitric oxide synthase expression were inhibited by DPP. The present study also figured out that these effects of DPP were mediated by blockade of caspase-1 and nuclear factor-B activation. Taken together, our results indicated that DPP could be alleviating fatigue as candidate of anti-inflammatory agent.