This study examined the moderated mediating effect of self-compassion through the degree of expressed emotion in the family on the effect of behavioral inhibition on depressive and anxiety symptoms. About 245 university students completed the following questionnaires: Korean version of Retrospective Self-Report of Inhibition (RSRI), Korean Levels of Expressed Emotion (K-LEE), Korean-version of Self-compassion Scale (K-SCS), Center for Epidemiologic Studies Depression Scale (CES-D) and State-Trait Anxiety Inventory (STAI). The main findings were as follows. First, behavioral inhibition, expressed emotion, self-compassion, and depressive and anxiety symptoms showed statistically significant correlations. Second, the results of bootstrapping indicated that expressed emotion mediated the effect of behavioral inhibition on depression and anxiety. Third, the moderation effect of self-compassion on the relationship between expressed emotion and depression was statistically significant based on hierarchical regression and slope analyses. Finally, self-compassion also moderated the mediating effect of behavioral inhibition on depressive symptoms via expressed emotion. The implications and limitations of this study are also discussed.