This study analyzed news coverage of nanotechnology in South Korea, Germany, Austria, and Japan between 2001 and 2015. It adopted a new approach using frame elements to identify frames and examined the methodological efficiency of the news approach. To identify the frames, this study executed two-step cluster analysis comprising a combination of hierarchical clustering and k-means clustering. First, six frames as clusters were identified as follows: overview of nanotechnology, policy, economic benefits, environmental risks, research and development, and health risks. Second, it was found that positive descriptions of nanotechnology were overwhelmingly more frequent than negative descriptions were. Third, there were obvious differences among countries even though they showed similar media frame patterns. Fourth, the more research and development increased over time, the more economic benefits decreased. By clustering frame elements, this study overcame the methodological limitation of frame studies. The study also contributes to the literature comparing media content between cultures and science communication studies."