Middle-aged women who have experienced the depression have been in pain for a long time. Depression in middle-aged women, which is rapidly increasing from their forties, has a problem that do not decrease in spite of various treatment methods. If the essential cause of depression in middle-aged women is due to the inability to detect the meaning of life because of the lack of the perception about the identity resulting from self-loss, a more qualitative research for a fundamental treatment method is required. The purpose of this study is to find out the essence and meaning of the experience of depression in middle-aged women and to help them to find their own selves through the process of individualization and to recover the whole health as well as to live as a self-transcendent being. Three Christian middle-aged women falling on critical and serious condition by BDI diagnosis were selected for the study. In-depth counseling and interviews were held from January to August 2018. In-depth counseling has provided detailed statements about the process of individualization of middle-aged women who have experienced depression, which applied 5 stages of Giorgi's Phenomenological Research Methodology. As a result, 261 semantic units and 11 sub-components were derived and structured by dividing them into two themes: depression experience and the process of individualization process, which are the subject group. This study has its significance in realizing essential meaning of pain by middle-aged women who experience depression and fundamentally preparing an opportunity to be cured through the process of individualization, as well as contributing for such middle-aged women to have abundant living by suggesting preventive measures to general middle-aged women who prepare for their old age.