Korean | English

pISSN : 1229-1854

2019 KCI Impact Factor : 1.01
Aims & Scope
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Journal of Korean Medicine Rehabilitation is an official journal of The Society of Korean Medicine Rehabilitation. It was launched in 1996, and accepts original research articles, reviews, short communications, case reports in the fields of Oriental Rehabilitation Medicine Research. The Journal is published in January, April, July and October each year. The official title of the journal is Journal of Korean Medicine Rehabilitation and the abbreviated title is 'JKMR.' All submitted manuscripts are peer-reviewed by three reviewers. The text may be written in Korean or English. The abstract and references should be written in English. This journal is indexed in the Korea Citation Index(KCI). For subscription, submission and all other information visit our website. The URL address of the Journal is http://www.e-jkmr.org/ where full text is available. This journal was supported by the Korean Federation of Science and Technology Societies Grant funded by the Korean Government (MEST).
Editor-in-Chief
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Yung-Sun Song

(Department of Korean Rehabilitation Medicine, Won Kwang University)

Citation Index
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  • KCI IF(2yr) : 1.01
  • KCI IF(5yr) : 0.66
  • Centrality Index(3yr) : 0.586
  • Immediacy Index : 0.413

Current Issue : 2020, Vol.30, No.4

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  • Effect of Pahyeolsandong-tang (Poxiesanteng-tang) in Tibia Fracture-induced Mice

    Woo-Suk Shin | Kira Parichuk | Cha Yun Yeop | 2020, 30(4) | pp.1~16 | number of Cited : 0
    Abstract
    Objectives The main purpose of this study was to evaluate the bone healing effect of Pahyeolsandong-tang (PHT)(Poxiesanteng-tang) extract in tibia fracture-induced mice. Methods PHT was extracted using a solution of 35% ethanol in 60°C for 8 hours. Mice were randomly divided into 4 groups (normal, control, PHT 50 and PHT 100). Mice of experimental groups were medicated with PHT 50 or 100 mg/kg for 7 to 21 days. To clarify the effect of bone fracture healing, relative messenger RNA (mRNA) expressions of osteocalcin (OCN), runt-related transcription factor 2 (Runx2), osterix (OSX), Sox9, collagen type Ⅱ alpha 1 chain (Col2a1), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) were examined. Results In in vitro experiment, relative mRNA expression of OCN, Runx2, Col2a1 was significantly increased in PHT treated group to compare with control differentiation group. In in vivo experiment, relative mRNA expression of OCN, Runx2, OSX, Sox9, Col2a1, RANKL, OPG was significantly increased in PHT treated group. Conclusions This study showed that PHT accelerates bone fracture healing through the activation of osteoclasts and osteoblasts. It was showed that PHT significantly promotes osteoblasts differentiation by osteoblast differentiation markers such as OCN, Runx2, Col1a2. Also it was investigated that PHT had stimulatory effect on osteoblasts function through enhancing OCN, Runx2, OSX, Sox9, Col2a1 and, osteoclasts function through enhancing RANKL and OPG markers. PHT effectively promotes bone fracture healing process through activation of osteoblasts and osteoclasts. (J Korean Med Rehabil 2020;30(4):1-16)
  • Healing Effect of Yukmijihwang-tang on Fracture Factor and Morphological Changes in Femur Fractured Mice

    Hyun-Seok Kim | Dong Hwi Jeon | Min-Seok Oh | 2020, 30(4) | pp.17~30 | number of Cited : 0
    Abstract
    Objectives The purpose of this study is to evaluate the healing effect of Yukmijihwang- tang (YM) on femur fractured mice. Methods Mice were randomly divided into 6 groups: normal, control, positive control, YM with low, medium, high dosage each. All groups were prepared with femur fracture and treated diffrently. In order to measure bone regeneration effects, we analysed the levels of cyclooxygenase-2 (COX2), bone morphogenetic protein-2 (BMP2), collagen type Ⅱ alpha 1 chain (Col2a1), Sox9, runt-related transcription factor 2 (Runx2), and osterix genes expressed in bone. For morphological analysis, muscles were removed and femur was observed with naked eye. Results COX2 gene expression in bone marrow significantly decreased. BMP2 gene expression significantly increased. Col2a1 gene expression significantly increased. Sox9 gene expression increased as well. Runx2 gene expression in bone marrow increased, but there was no statistical significance. Osterix gene expression significantly increased. Union of the fracture site progressed more in YM group compared to the control group. The fracture union score was significantly decreased in YM group compared to the control group. Conclusions YM showed anti-inflammatory effect, promoted bone regeneration by stimulating the bone regeneration factor. In conclusion, YM can help fracture healing and it well be applied clinically to patients with fracture. (J Korean Med Rehabil 2020;30(4):17-30)
  • Comparison of Ingredients and Activities of Danggwisoo-san and Jakyakgamcho-tang by Extraction Method

    Dae-Yeon Lee | Ho-Sung Lee | Ju-hwi Jo and 6other persons | 2020, 30(4) | pp.31~39 | number of Cited : 0
    Abstract
    Objectives Danggwisoo-san and Jakyakgamcho-tang are frequently prescribed for traffic accident patients in Korea. The aim of this study was to examine index compound analysis, antioxidant activity and amount of starch measurement by extraction method. Methods Danggwisoo-san and Jakyakgamcho-tang were extracted with water and 70% ethanol. Antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazyl, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and ferric reducing antioxidant power according to the standard protocol. The contents of the indicator components nodakenin, paeoniflorin, and glycyrrhizin were measured by high-performance liquid chromatography, respectively. All starches were hydrolyzed and then total D-glucose was measured and compared. Results Antioxidant activity was excellent in 70% ethanol in all assays. The index component was jagged because its solubility was different depending on the extraction solvent. Starch content was significantly lower in 70% alcohol extract than water extract. Conclusions The results of this study showed that physiological activities and components are different according to extraction conditions. Each herbal medicine has a suitable extraction solvent. Also, the difference in starch content is an object to be considered as it may affect digestion and absorption. (J Korean Med Rehabil 2020;30(4):31-39)
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