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2006, Vol.16, No.3

  • 1.

    Inhibitory Effect of Kuseupbokhap-bang on (Qùshīfùhé-fāng)Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes

    한주원 | Minseok Oh | Yoon il ji and 1other persons | 2006, 16(3) | pp.1~16 | number of Cited : 6
    Abstract
    Objectives : This study was carried out to know the inhibitory effect of Kuseupbokhap-bang(Qùshīfùhé-fāng; KC) on rheumatoid arthritis in human fibroblast-like synoviocytes(hFLSs). Methods : For this purpose, experiments were performed to measure the cytotoxicity against hFCs and the production of pro-inflammatory cytokines in hFLSs and the production of NO, ROS. Results : KC had no cytotoxicity against hFCs and reduced the production of pro-inflammatory cytokines TNF-α, IL-6, IL-8, IL-1β in hFLSs, increased the production of TIMP-1. As well as KC reduced the production of MMP-3, NOS-II, ICAM-1, the production of Nitric oxide and ROS, and the proliferation of hFLSs in proportion to the concentration of KC significantly. Conclusions : Comparison of the results for this study showed that KC had immunomodulatory effects of suppressing or enhancing.
  • 2.

    Effects of Bee-venom(BV) and Cheongyeolsaseup-tang(Qingrexieshi-tang) onType Ⅱ Collagen-Induced Arthritis

    정순구 | Jin-Bong Choi | 설재욱 | 2006, 16(3) | pp.17~33 | number of Cited : 0
    Abstract
    Objectives : This study was carried out to investigate the effects of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract on type Ⅱ collagen-induced arthritis rats. Then, we compare separateness with combination of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang). Methods : We observed inhibitory effect of edema, analgesic effects by hot plate, analysis of blood chemistry(WBC, ALT, AST), western blot(IL-6, cPLA2), histopathological and radiological changes. Results : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract significantly inhibited the rate of paw edema compared with control group and reduced WBC, the time of heat threshold, AST(Asparatate transaminase), ALT(Alanine transaminase), the mass of IL-6, cPLA2 in synovia compared with control group in immunological test. On the histopathological view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. On the radiological view, all experimental groups were improved. Conclusions : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of BV and CST.
  • 3.

    The Effect of Chongbaek-san(Congbai-san) on the Body Weight and the Histological Changes in Peri-Epididymal Fat, the Biochemical Changes of Blood Serum in Obese Rats Induced by High Fat Diet

    노도환 | Myeong-Jong Lee | 2006, 16(3) | pp.35~47 | number of Cited : 0
    Abstract
    Objectives : This study was performed to investigate the efficiency of Chongbaek-san(Congbai-san) on the Weight changes and the histological changes in Peri-Epididymal Fat, the biochemical changes of blood serum in obese rats induced by high fat diet. Methods and Materials : Experiment animals were divided into 3 groups; normal group(normal diet, non-treated), obese group(high fat diet, non-treated) and Chongbaek-san(Congbai-san) oral feeding obese group(high fat diet, treated). Results : Chongbaek-san(Congbai-san) was investigated effects of Total Body Weight, serum Glucose and Insulin content, Total Cholesterol and Triglyceride, HDL-Cholesterol, LDL-Cholesterol content, Total Lipid and free fatty Acid content, Leptin and Uric Acid, SGOT, SGPT content, the histological changes in Peri-Epididymal in animal test. However there was no significant difference in Insulin and HDL-cholesterol. Conclusions : These results indicates that Chongbaek-san(Congbai-san) showed the treatment effects on the obesity resulted from high fat diet in rats.
  • 4.

    The Study of Naetakcheongeum-san(Neituoqianjin-san) on Anti-Cancer Effects and Mechanisms in Human Leukemic HL-60 Cells

    김상돈 | Kwon Kang-Beom | Shin, Byung Cheul and 4other persons | 2006, 16(3) | pp.49~64 | number of Cited : 2
    Abstract
    Objectives : The aim of this study was to investigate the apoptotic effects and mechanisms of Naetakcheongeum-san(Neituoqianjin-san) extract (NCSE)-treated on HL-60 leukemic cells. Methods : It was observed that NCSE induced apoptotic changes in a dose-dependent patterns, which was confirmed by DNA fragmentation and an increase of annexin V+/PI- stained cell population. It was monitored that the activation of caspase-3, -8, -9 enzyme activities and the cleavages of those in NCSE-treated HL-60 cells. We investigated the release of cytochrome c from the mitochondria to the cytosol and the bid cleavage in time- and dose-dependent patterns in HL-60 cells. To clarify the involvement of caspases, we used the inhibitors. Cells treated with the caspase-3 inhibitor, Ac-DEVD-CHO, and the caspase-8 inhibitor, z-IETD-FMK and the caspase-9 inhibitor, z-LEHD-FMK. Results and conclusions : It is suggested that NCSE-induced apoptosis is predominant through the activation of caspase-3 and -8 in HL-60 cells.
  • 5.

    Review of Literature on Herbal Medicines for the Treatment of Obesity in Korea - Mainly papers since 2000

    황미자 | SHIN HYUN DAE | Mi-Yeon Song | 2006, 16(3) | pp.65~81 | number of Cited : 15
    Abstract
    목적: 비만은 단지 용모 손상뿐만 아니라 당뇨나 고혈압과 같은 질환을 유발하고 지속시키는 만성적인 질환으로 인식되고 있다. 비만을 치료하기 위한 한약의 사용이 증가되고 있다. 2000년 이후에 나온 국내 한방 논문 및 pubmed 논문에 실린 비만 치료 한약을 분석함으로써 한국에서 비만에 주로 연구되는 한약에 대해 알고자 하였다. 방법: KSI 한국 학술정보 및 MEDLINE을 ‘비만', ‘체중조절', ‘체중감량', ‘한약'으로 검색하고, 한방재활의학과학회지, 대한한방비만학회지에 게재된 논문 중 비만에 한약을 사용한 논문을 대상으로 하여 빈도를 계산한 후, 처방에 포함된 한약을 참고하여 실제 한약물의 빈도를 계산하였다. 결과: 분석 대상 논문 총 72편, 이 중 한국어 논문 50편, pubmed 논문 22편 중 미국 14편 한국 3편 일본 5편이었다. 한국에서 가장 빈용되는 한약은 사상처방(太陰調胃湯 8회, 調胃升淸湯 5회) 및 體感薏苡仁湯(11회)이었으며, 방제 구성을 고려할 때 빈용 약물은 薏苡仁, 當歸, 甘草, 蘿葍子, 川芎, 麻黃, 桔梗, 熟地黃, 枸杞子, 黃芪 순으로 나타났다. 단미로는 麻黃이 빈도가 제일 높았다. 미국에서는 주로 단미로 연구가 이뤄지고 있었으며, 麻黃이 제일 많고 人蔘, 枳實, 生薑 등이 연구되고 있었다. 결론: 한국에서 비만에 빈용되는 처방은 四象醫學에 기초한 처방으로 나타났다. 四象醫學은 사람을 네 체질로 나누고, 이 중 太陰人이 비만해지기 쉽고 체중감량은 어렵다고 하였으며, 태음인 처방에 麻黃이 포함된 것이 많았다. 이는 단미로써 사용될 때 문제시되는 麻黃의 부작용이 적절한 대상 선택과 적절한 한약 혼합을 통해 줄어들 수 있음을 시사한다.
  • 6.

    The Effect of Dong-Si Acupoint on the Meridian Muscle Tension of Governer Vessel and Bladder Meridian

    조재흥 | Chung, Seok Hee | Sungsoo Kim | 2006, 16(3) | pp.83~92 | number of Cited : 0
    Abstract
    Objectives : To investigate the effect of Dong-si acupoint(Ling-gu, Da-bai) on the tension of Governer vessel and Bladder meridian muscle. Methods : Sample group of 15 healthy subjects had been treated by acupuncture on Dong-si acupoint(Ling-gu, Da-bai) which has been proved effective against back pain and sciatica. Control group of 15-healthful subjects had not treatment during 5 minutes after first check. Outcomes were assessed at just before a step and after 5 minutes by finger to floor method(FFM) for hamstring muscle, back distance method for erector spinae muscle and Meridian-Electromyograph(MEMG) for both muscles. Results : The tension of both muscles assessed by FFM and MEMG had decreased significantly in sample group, while muscle tension assessed by back distance method had no statistical significance. Control group had not produced meaningful consequence on all assessment. Conclusions : Dong-si acupoint(Ling-gu, Da-bai) can usefully reduce the tension of Governer vessel and Bladder meridian muscle, which is accounted for meridian muscle conducting muscle tension between two-body parts distant from each other.
  • 7.

    Meridian Muscle Acupuncture for Chronic Shoulder Pain

    윤원석 | Seung-ryong Yeom | SONG YUNG SUN and 3other persons | 2006, 16(3) | pp.93~101 | number of Cited : 0
    Abstract
    목적 : 본 임상연구의 목적은 3개월의 추시 연구를 통하여 만성 견부 통증에 대한 經筋 자극침 (Meridian Muscle Acupuncture (MMA)의 효과를 알아보기 위함이다. 방법 : 40명의 지원자를 대상으로 2004~2005년까지 대조 임상연구를 수행하였다. 經筋 검사 (MMT)를 시행하여 진단된 經絡을 자극하는 침술을 20명의 지원자에게 1주일에 3회씩 4주간 시행하였다. 대조군은 20명의 지원자에게 경구 비스테로이드 소염진통제 (aceclofenac 100mg, 1일 2회, tolperisone 100mg, 1일 3회) 복용하였다. 물리치료 (hot pack, TENS)는 두 집단에서 동일하게 1주일에 3회씩 4주간 치료하였다. 시각적 상사 척도 (VAS)와 운동 가동역 (ROM)의 변화는 치료전과 치료후에 측정하였고, 장기 추시 상태는 통증과 일, 생활 상태 지수 (PWLS; 1-4)를 이용하여 4주 후, 12주 후 측정하였다. 결과 : 평균 연령은 53±12.9세(23~80)이었고, 균질성 검사에서 나이, 치료 전 운동 가동역, 시각적 상사 척도는 두 그룹간 차이가 없었다. 시각적 상사 척도와 운동 가동역 점수는 대조군보다 經筋 자극침 그룹에서 더 큰 호전을 보였다 (p<0.05). PWLS의 장기 추시 상태는 대조군보다 經筋 자극침 그룹에서 보다 향상된 효과를 나타내었다 (p<0.05). 결론 : 經筋 자극침은 만성 견부 통증에 효과적이었다. 經筋 자극침은 한방의 經筋 이론과 서양의 근막 경선 이론을 결합한 방법으로 근골격계 통증을 조절하는 하나의 방법이 될 수 있을 것으로 사료된다.
  • 8.

    A Study on the Correlation of Shoulder Pain and Meridian Muscle Electrography in Hemiplegic Patients after Stroke

    김민범 | Jongsoo Lee | Sungsoo Kim | 2006, 16(3) | pp.103~110 | number of Cited : 6
    Abstract
    Objectives : The purpose of this study was to investigate the correlation of shoulder pain and meridian muscle electrography in hemiplegic patients after stroke. Methods : Twenty patients with hemiplegic shoulder pain participated in this study. Physical examination, pain survey and meridian muscle electrography were performed. Each variable was compared with each other by correlation analysis. Results : Correlation between visual analogue scale and meridian muscle electrography statistically significant in contraction power ratio of deltoid muscle medial portion and trapezius muscle upper portion, others were not significant. Conclusions : In hemiplegic shoulder pain patients, the more patients complain about pain, the more tone of affected muscle is similar unaffected muscle. This suggests that pain influences on muscle tone. Although meridian muscle electrography is not typical method for the evaluation of painful hemiplegic shoulder, this is referential method to clinical evaluation.
  • 9.

    A Study on Physical Fitness Level of Adults According to Sasang Constitution

    조태영 | Lim Hyung Ho | 장 건 and 2other persons | 2006, 16(3) | pp.111~125 | number of Cited : 0
    Abstract
    Objectives : The study was done to provide basic data for physical fitness level of adults according to sasang constitution. Methods : The subjects of this study are thirty adults who ranged in age 20s-70s yr and selected out of two-hundred people that examed healthy medical check in Kyungwon college at 30. Oct. 2005. They were diagnosed by QSCC Ⅱ and tested physical fitness. Results : 1. Of those 30 observed, 11(36.67%) were categorized in Soyangin, 10(33.33%) in Taeumin, 9(30.00%) in Soeumin. 2. Compared to muscular strength level of Soyangin and Soeumin, Taeumin have high level of muscular strength level. In Taeumin group, muscular strength score is significantly higher than Soyangin and Soeumin group(p<0.05). 3. Compared to muscular endurance level of Soyangin and Soeumin, Taeumin have high level of muscular endurance level. In Taeumin group, muscular endurance score is significantly higher than Soyangin and Soeumin group(p<0.05). Conclusions : As see in above results, muscular strength and muscular endurance show significantly higher with Taeumin than with Soyangin and Soeumin.
  • 10.

    A Study on the Pelvic Deviation According to Delivery Types, Frequency and Experience(A Radiological Study)

    김철한 | Jeong Yeon Kim | Shin, Byung Cheul | 2006, 16(3) | pp.127~136 | number of Cited : 5
    Abstract
    Objectives : Women can be affected psychologically and physically by pregnancy and delivery. Many Changes during the pregnancy and the delivery process lead to the deviation of pelvis and lumbosacral joint. It was investigated pelvic deviation and lumbosacral angle to know the changes of pelvis and lumbosacral joint according to delivery types, frequency and experience. Methods : 106 lying-in women and 33 unmarried women were evaluated by X-ray findings. All lying-in women divided into two groups according to delivery types and frequency. After measuring innominate measurment, off centering measurement, sacral ala measurement, ilium shadow measurement, width of symphysis pubis and lumbosacral angle, X-ray findings in each two lying-in women and nullipara group were analyzed statistically. Results and Conclusions : It was concluded that the width of symphysis pubis was more wider in normal delivery group than nullipara group. Lumbosacral angle was larger in multipara group than nullipara group, and in lying-in women group than nullipara group.
  • 11.

    Minnesota Multiphasic Personality Inventory Responses of Traffic Accidental Patients-Followed the Type of Traffic Accident, Posttraumatic Stress Disorder and Sex-

    설재욱 | Kyeong-Ok Kim | Jin-Bong Choi and 4other persons | 2006, 16(3) | pp.137~148 | number of Cited : 9
    Abstract
    Objectives : To evaluate and find out psychological characteristics of traffic accident(TA) patients who were diagnosed as sprain of C-spine and L-spine, and suffering from psychological disorder. Methods : 35 patients wrote out Minnesota Multiphasic Personality Inventory(MMPI). We divided them into four groups according to the type of TA - car to car and car to person, posttraumatic stress disorder(PTSD) and sex. We sent medical records and MMPI reports to Dept. of Oriental Neuropsychiatry Medicine and asked who were PTSD patients. Results : 1-3/3-1 profile was found by total mean of T score of each MMPI scale in all patients. 1-3 profile was found in car to car and non-PTSD group. 3-1 profile was found in car to person and PTSD group. The difference was not valid by the type of TA, PTSD and sex(p<.05) except for the clinical scale of hysteria. Conclusions : The results indicate that MMPI characteristics of TA patients were generally 1-3/3-1 profile and patients who showed 3-1 profile must be treated more carefully because they were underlying PTSD patients.
  • 12.

    Magnetic Resonance Imaging Follow-Up Study on the Case of Protruded Lumbar Intervertebral Disc Herniation through Chuna Therapy

    정 벌 | Chung, Seok Hee | Jongsoo Lee | 2006, 16(3) | pp.149~157 | number of Cited : 8
    Abstract
    Objectives : There are many studies on the resorption of extruded lumbar intervertebral disc herniation by MRI follow-up case study but few are about protrusion. So the purpose of this study is to know the difference of MRI scan on protrusion type after Chuna theraphy. Methods : The first MRI examination was performed at the first visit suffering from LBP and radiculopathy, and the second performed after treatment. The first image was compared with second one. Results & Conclusions : The second scan shows clearly disc resorption of L4-5 level compared with previous scan and clinical symptom assessed by VAS was also reduced after Chuna theraphy.
  • 13.

    A Case of Prescribing Beewha-eum(Bihe-yin) for the Patient with Polyneuropathy Diagnosed as Deficiency Syndrome of Spleen and Stomach

    고병표 | 김수진 | 고태현 and 2other persons | 2006, 16(3) | pp.159~167 | number of Cited : 2
    Abstract
    Objectives : This study is to report a case that polyneuropathy can be caused by deficiency syndrome of spleen and stomach. Methods : The patient had eaten almost nothing and felt nausea for four months, so we diagnosed his case as deficiency syndrome of spleen and stomach in the point of oriental medicine, and prescribed Beewha-eum(Bihe-yin) for him with acupuncture, physical therapy and dosage of western medicine for a certain period. And we adopted several scales to estimate the progress of his symptoms. Results : Soon after taking herbal medication with other treatments, the patient could recover an appetite and was able to eat without nausea. Besides recovering an appetite, other symptoms such as weakness and paresthesia of both legs were also improved. Conclusions : In this case, we assume that Beewha-eum(Bihe-yin) play an important role in improvement of his polyneuorpathy. The Beewha-eum(Bihe-yin) is one of herb medications that correct deficiency syndrome of spleen and stomach. In the view of oriental medicine, spleen and stomach control the limbs. So in this case recovered stomach and spleen by Beewha-eum(Bihe-yin) improved the weakness and paresthesia of both legs. Therefore we can use Beewha-eum(Bihe-yin) for treating polyneuropathy caused by deficiency syndrome of spleen and stomach.
  • 14.

    Effect of Gamihwalhyul-tang(Jiaweihuoxie-tang) on Memory Disturbance Caused by Head Trauma

    허성규 | Kim,Dong-Kun | Cha Yun Yeop and 3other persons | 2006, 16(3) | pp.169~176 | number of Cited : 2
    Abstract
    Objectives: The purpose of this study was to investigate the clinical application of oriental medical therapy to a patient with memory disturbance and disorientation caused by head trauma. Methods: This study was carried out on a patient who had a memory disturbance caused by head trauma, and whose condition was improved through herbal medication and acupuncture therapy. We estimated the effect of memory disturbance through MMSE-K(Korean Vision of Mini-Mental State Examination) and K-DRS(Korean-Dementia Rating Scale). Results and conclusions: Following the treatment the patient's mental state was improved. The present results suggest that oriental medical therapy has the positive effects on a patient with memory disturbance.
  • 15.

    A Case Report of The "Top of Basilar" Syndrome; with Vertebral Artery Occlusion

    김세진 | Misook Shin | Jin-Bong Choi and 3other persons | 2006, 16(3) | pp.177~190 | number of Cited : 0
    Abstract
    Objectives : The aim of the present study is to report a 38-year-old patient with 'top of basilar(TOB)' syndrome who shows paralysis of limbs, diplopia, facial numbness, neck weakness by vertebral artery occlusion. Methods : We treated the patient by acupuncture, herbal medication, physical therapy, rehabilitative therapy such as eye exercise. We used evaluation scale including Visual Analog Scale(VAS), National Institutes of Health Stroke Scale(NIHSS), Modified Barthel Index(MBI), Manual Muscle Testing(MMT). Results and Conclusions : Analysis of this one patient indicated that oriental medical rehabilitative therapy is useful to treat the TOB syndrome. The symptoms were improved rapidly. After treatment, the patient was able to walk and diplopia was improved. MBI score changed from 20 to 95, for NIHSS from 13 to 2. VAS and MMT were also numerically improved.