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2008, Vol.18, No.2

  • 1.

    The Experimental Effect of Haedongpibokhap-bang (Haitongpifuhe-fang) on Collagen-induced Arthritisgroup. So, further studies will be needed.

    공상은 | Minseok Oh | 2008, 18(2) | pp.1~15 | number of Cited : 7
    Abstract
    Objectives : The aim of this study was to know the immuity response of Haedongpibokhap-bang(Haitongpifuhe-fang) to rheumatoid arthritis in collagen-induced arthritis(CIA) mice. Methods : For this purpose, Haedongpibokhap-bang(Haitongpifuhe-fang) was orally administerd to mice with arthritis induced by collagen Ⅱ and then value of immunocyte in spleen, draining lymph node and paw joint and cytokine(IL-6, TNF-α), rheumatoid factor (IgG and IgM) in serum were measured. Results : 1. The arthritis index was significantly decreased. 2. In total cell counts of spleen, DLN and paw joint, the cells in spleen decreased while there was a significant increase in DLN and significant decrease in paw joint. 3. In lymph nodes, CD3+, CD3+/CD69+, CD4+, CD8+ cells increased significantly. 4. In joints, CD3+ and CD11+b/Gr-1+ cells decreased significantly. 5. Serum IL-6 and TNF-α were decreased significantly. 6. Production of serum IgG and IgM decreased significantly. Conclusions : The results present that Haedongpibokhap-bang(Haitongpifuhe-fang) controls abnormal activity of immune system, inhibitig collagen-induced arthritis(CIA).
  • 2.

    Effects of Samgi-eum(Sanqi-yin) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats

    이경무 | kim Sun Jung | Seo,Il-bok and 1other persons | 2008, 18(2) | pp.17~31 | number of Cited : 6
    Abstract
    Objectives : This study was carried out to investigate the effects of Samgi-eum(Sanqi-yin) on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Osteoarthritis was induced by injection of monosodium iodoacetate intraarticularly in both knee joints. Arthritic rats were divided into control and treated group. Control group were taken distilled water for 20days. Treated group were taken extracts of Samgi-eum(Sanqi-yin) by orally for the same duration. Normal group were injected normal saline and taken distilled water. Body weights were measured at 0, 5th, 10th, 15th, 20th day after injection. At the end of the experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan contents of articular cartilages were analyzed by safranine O staining method. The contents of TNF-α, IL-1β and IL-6 in synovial fluids were analyzed by ELISA method. Results : 1. Body weights of the treated group were significantly increased compared with control at 20days after injection. 2. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control. 3. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control and histopathological scores of treated group were significantly decreased compared with control. 4. PG contents in articular cartilages of the treated group were significantly increased compared with control. 5. TNF-α contents in synovial fluids of the treated group were significantly decreased compared with control. Conclusions : According to above results, Samgi-eum(Sanqi-yin) has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it is related with reduced secretion of TNF-α from osteoarthritic chondrocytes and synovial membranes.
  • 3.

    Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats

    정벌 | Jongsoo Lee | 2008, 18(2) | pp.33~43 | number of Cited : 2
    Abstract
    Objectives : Sunghyangjungki-san(Xingxiangzhengqi-san) is a herb decoction prescribed frequently for stroke patients. The present study investigated neuroprotective effects of Sunghyangjungki-san(Xingxiangzhengqi-san) against the ischemic damage of the rat brain. Neuronal cell death under the cerebral ischemia is distinguished with the delayed cell death through apoptosis. Consequently, the effects of Sunghyangjungki-san(Xingxiangzhengqi-san) was evaluated with Bax and Bcl-2 expressions as apoptosis related factors in the brain tissues. Methods : The ischemic damage was induced by the middle cerebral artery occlusion(MCAO) method in Sprague-Dawley rats. Water extract of Sunghyangjungki-san(Xingxiangzhengqi-san) was treated for 5 days after the MCAO. Neurological scores and infarct size with TTC were measured. Bax and Bcl-2 expressions in the brain tissues were observed with immunohistochemistry. Results : Sunghyangjungki-san(Xingxiangzhengqi-san) treatment improved neurological score significantly at 5 days after the MCAO. Sunghyangjungki-san (Xingxiangzhengqi-san) treatment decreased infarct size by the MCAO, but it was not significant statistically. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment attenuated Bax positive neurons significantly in the cerebral penumbra and the caudate putamen. Bcl-2 positive neurons were increased, but not significant. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment increased Bcl-2/Bax expression ratios significantly in the cerebral penumbra and the caudate putamen. Conclusions : These results suggest that Sunghyangjungki-san(Xingxiangzhengqi-san) has a neuroprotective effect on the stroke with modulation of apoptosis related factors.
  • 4.

    Neuroprotective Effects of Sopung-tang(Shufeng-tang) on Cognition and Motor Function Recovery after Ischemic Brain Injury in Rats

    추민규 | Misook Shin | Jin-Bong Choi and 1other persons | 2008, 18(2) | pp.45~60 | number of Cited : 4
    Abstract
    Objectives : Sopung-tang(Shufeng-tang) is a famous herbal prescription that treated ischemic brain injury. This study was designed to evaluate the effects of Sopung-tang(Shufeng-tang) on congnition and motor function recovery after ischemic brain injury in rats. Methods : Male rats were divided into 4 groups. Those rats caused ischemic brain injury by occlusion of MCA as Longa method. Control groupⅠwas per os normal saline for 7 days after ischemic brain injury. Control group Ⅱ was per os normal saline for 14 days after ischemic brain injury. Experimental groupⅠ(Ex Ⅰ) was taken with Sopung-tang(Shufeng-tang) for 7 days after ischemic brain injury. Experimental group Ⅱ(Ex Ⅱ) was taken with Sopung-tang(Shufeng-tang) for 14 days after ischemic brain injury. The author carried out neurological, cognitive motor behavior tests and histological assessment. Neurological motor behavior tests consist of limb placement test, beam-walking test and horizontal wire test. Morris water maze test was used for cognitive motor behavior test. In the histological assessment test, TTC(2,3,5-triphenylteterazolium chloride) staining, Hematoxylin & Eosin staining and immunohistochemical staining were experimented. Results : 1. In neurological motor behavior tests, motor function recovery was significantly increased in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 2. In Morris water maze test, congnitive motor function recovery was significantly incresed in the experimental groups as compared with control groups(p<0.05). Especially Ex Ⅱ was significantly increased as compared with Ex Ⅰ(p<0.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially most immune reaction was experimented in the Ex Ⅱ. Conclusions : According to the above results, Sopung-tang(Shufeng-tang) can treat on the congnition and motor function recovery after ischemic brain injury in rats. And it is effective method in expression of BDNF in hippocampus.
  • 5.

    Effects of Dokwal-tang(Duhuo-tang) and Jungsongouhyul Pharmacopuncture on Pain Control and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve

    송정섭 | SONG YUNG SUN | Shin, Byung Cheul and 3other persons | 2008, 18(2) | pp.61~79 | number of Cited : 10
    Abstract
    Objectives : The purpose of this study was to identify the effect of Dokwal-tang(Duhuo-tang) and Jungsongouhyul Pharmacopuncture on pain control and nerve regeneration after crush injury in rat sciatic nerve. Methods : Animal model was produced through right sciatic nerve crush injury and they were randomly divided into four groups; Group I: no treatment control group; Group II: experimental group treated with Dokwal-tang(Duhuo-tang); Group III: experimental group treated with Jungsongouhyul Pharmacopuncture; Group IV: experimental group treated with Dokwal-tang(Duhuo-tang) and Jungsongouhyul Pharmacopuncture. For the pain assessment, this study was observed the paw withdrawal latency(PWL) and immunoreactivity on the substance-P. For the nerve regeneration assessment, the sciatic functional index(SFI) and immunoreactivity on the GAP-43 were measured. Results : 1. In the pain assessment, the PWL of experimental groups were significantly higher than control group and group IV was significantly higher than other groups. 2. In immunohistochemical response of substance-P, as time passes, all groups had decreased immunoreactivity gradually. Specially, group IV was observed the lowest immunoreactivity. 3. In the assessment of SFI, the SFI of experimental groups were significantly higher than control group. 4. In immunohistochemical response of GAP-43, all groups had higher GAP-43 immunoreactivity at the 14 days from post-injury and at the all days, control group was observed most lower immunoreactivity and group IV was observed most higher immunoreactivity. Conclusions : These results of this study suggest that Dokwal-tang(Duhuo-tang) and Jungsongouhyul Pharmacopuncture was related with pain inhibition and motor nerve recovery, and decreased substance-P expression and increased GAP-43 expression after sciatic nerve crush injury.
  • 6.

    The Inhibitory Effects of Gamipalmul-tang(jiaweibawu-tang) on the Obese-Mice Induced by High Fat Diet

    김효영 | Dongseok Heo | 2008, 18(2) | pp.81~96 | number of Cited : 2
    Abstract
    Objectives : This study was performed to investigate inhibitory effects of Gamipalmul-tang(jiaweibawu-tang) on the hematological and histological changes of obese mice. Methods : C57BL/6 mice were divided into four groups (normal group, high fat diet with normal saline, high fat diet with reductil, high fat diet with Gamipalmul-tang(jiaweibawu-tang)) and fed for 8 weeks. Body weight change, final increase of body weight, ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, glucose, cell viability by cytotoxicity, the expression of β3AR in 3T3-L1 cell, the expression of leptin, β3AR and serotonin in adipocyte tissue and size of adipocyte were observed in 8 weeks. Results : 1. In 3T3-L1 cell. the expression of β3AR was increased significantly. 2. The final increase of body weight in obese-mouse were decreased significantly. 3. The level of AST, ALT were decreased significantly. 4. The level of LDL-cholesterol was decreased significantly and HDL-cholesterol was increased significantly. 5. The levels of triglyceride was decreased and leptin and glucose were decreased significantly. 6. In adipocyte tissue, the expression of β3AR were increased significantly. 7 In adipocyte tissue, the expression of leptin and serotonin were decreased significantly. 8. The size of Adipocyte was decreased. Conclusions : On the basis of these results, we concluded that Gamipalmul-tang(jiaweibawu-tang) has inhibitory effects in rat.
  • 7.

    Effects of Kyungohkgo(Qiong yu gao) on Growth and Learning Ability in Growth Deficiency Rat with Insufficient Nutrition Diet

    한석훈 | Cha Yun Yeop | Lee,Eun | 2008, 18(2) | pp.97~109 | number of Cited : 2
    Abstract
    Objectives : Effects of Kyungohkgo(Qióng yù gào) on intellectual development and learning ability were investigated growth and intellectual impairment rat with insufficient nutrition diet. Methods : We divided male Sprague-Dawley rats into 4 groups(A, B, C, D). They were normal group(A), growth deficiency rat with insufficient nutrition diet group(B), growth deficiency rat with 0.1% Kyungohkgo(Qióng yù gào) group(C) and growth deficiency rat with 0.2% Kyungohkgo(Qióng yù gào) group(D). They were administered for 5 weeks. We measured body weight, serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, RBC, concentration of Hb and PCV ratio, total WBC and its composition, the values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities and morris water maze test in escape distance, escape time and escape speed. Results : 1. Body weight showed a tendency to increase in the Kyungohkgo(Qióng yù gào) groups and 0.2% Kyungohkgo(Qióng yù gào) group showed significantly different than control groups. 2. Serum growth hormone, insulin-like growth factor and thyroid stimulating hormone showed a tendency to increase in Kyungohkgo(Qióng yù gào) groups, however these values showed no significantly different. 3. About the counts of RBC, 0.1% and 0.2% Kyungohkgo(Qióng yù gào) groups showed significantly different than control groups. Concentration of Hb was higher than control group in Kyungohkgo(Qióng yù gào) groups. And 0.2% Kyungohkgo(Qióng yù gào) group showed significantly different than control groups in PCV ratio. 4. The counts of total WBC and its composition showed no significantly different in all treatment groups. 5. The values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities showed no significantly different in all treatment groups. 6. In the morris water maze test, in escape distance and escape speed, Kyungohkgo(Qióng yù gào) groups showed no significantly different than control group. But Kyungohkgo(Qióng yù gào) groups showed the increasing tendency. Conclusions : So Kyungohkgo(Qióng yù gào) have an effect of promoting growth of rats and might be effect to treat various kinds of growth delay in children.
  • 8.

    Two Clinical Cases on Plantar Fasciitis Using Myofacial Releasing Therapy and Acupuncture Therapy

    황형주 | 이길준 | Keum Dong-ho and 1other persons | 2008, 18(2) | pp.111~118 | number of Cited : 4
    Abstract
    Objectives : Plantar fasciitis is most common cause of heel pain which starts from anterior tubercle of calcaneus. It is chronic inflamation of plantar fascia, reduces collagen and water content of heel pad which incur the degenerative changes with elastic fiber weakness. We have evaluated the effect of myofacial releasing therapy and acupuncture therapy by experimenting two patients suffering from plantar fasciitis. Methods : Two patients were diagnosed as plantar fasciitis through their symptoms. We used myofacial releasing therapy and acupuncture therapy to the patients and measured VAS(Visual analogue scale). Results and Conclusions : After treating myofacial releasing therapy and acupuncture therapy in two cases, We figured out that the patients were on the mend. These results suggest that myofacial releasing therapy and acupuncture therapy were effective to heel pain.
  • 9.

    A Pilot Study on Skin Resistance Variability (SRV) of Traffic Accident Patients - Focus on Factor AA -

    허성규 | Cha Yun Yeop | 2008, 18(2) | pp.119~130 | number of Cited : 5
    Abstract
    Objectives : The purpose of this study was to compare mean values of Factor AA on Skin Resistance Variability(SRV) of traffic accident patient group with those of non-traffic accident patient group(control group) by using 7-Zone-Diagnostic System. Methods : Two groups were selected from those who took the CP-6000A test in College of Oriental Medical Hospital of Sang-Ji University from March 2007 to November 2007. Two groups were control group(n=61) and traffic accident patient group(n=62). Mean values of Factor AA on Skin Resistance Variability(SRV) of two groups were compared. Results and Conclusions : The results suggest that traffic accident patient group and non-traffic accident patient group had problems in circulation but non-traffic accident patient group had more problems than traffic accident patient group, and that after oriental medical therapy, non-traffic accident patient group was more improved than traffic accident patient group. So, further studies will be needed.
  • 10.

    The Influence of Predisposing Factors and Sign of Hypoadrenia on Autonomic Nervous System Activity and Salivary Cortisol

    Jeong-Ho Lee | Myong Jong Yi | Seongmin Kim and 1other persons | 2008, 18(2) | pp.131~142 | number of Cited : 3
    Abstract
    Objectives : This study was performed to identify the influence of salivary cortisol and HRV(Heart rate variability) on hypoadrenia predisposing factors and sign. Methods : 30 patients with chronic fatigue symptom belonging to Shen xu(腎虛) were recruited for investigation from March to April 2007. The participants were divided into HS(High score) group(n=15) and LS(Low score) group(n=15) in predisposing factors of adrenal questionnaire. At the same time equal patients separated into OH(+)(Orthostatic hypotension positive) group(n=12) and OH(-)(Orthostatic hypotension negative) group(n=18). Salivary cortisol and HRV made use of evaluating hormonal imbalance and autonomic nervous system of hypoadrenia. Results : Salivary cortisol at P.M.4 in HS group was significantly(p=0.011) lower than LS group. And LF(Low frequency) of OH(+) group was considerably(p=0.014) lower than OH(-) group. Conclusions : Shen xu bian zheng(腎虛辨證), measure of orthostatic hypotension, predisposing factors of adrenal questionnaire, salivary cortisol and HRV deserve clinical application for management of subclinical hypoadrenia.
  • 11.

    Correlation between Visceral Adipose Tissue and Stagnation of the Liver Qi (gan-yu, 肝鬱) in Korean Perimenopausal Women

    황미자 | Chung, Seok Hee | Mi-Yeon Song and 1other persons | 2008, 18(2) | pp.143~156 | number of Cited : 11
    Abstract
    목적 : 갱년기 여성은 내장비만의 위험이 높으며 또한 심리적 변화를 겪는 시기이다. 갱년기 여성의 복부지방, 내장지방, 피하지방 및 이와 관련된 단순비만지표, 간울증, 스트레스, 우울, 자존감 등을 조사하여 갱년기 건강의 위협이 되는 신체 심리 인자를 알아보고자 이 연구를 시행하였다. 방법 : 병원공고를 통해 체질량지수 23 kg/m2 이상 비흡연자인 만 45세 이상 55세 이하의 폐경 전후의 갱년기 여성 환자를 모집하여 2007년 8월 20일부터 24일까지 47명이 모집되었으며 이중 체질량지수 25 kg/m2 이상이면서 복부 전산화 단층촬영 상 내장지방이 100 cm2 이상인 20명의 단순비만지표, 체성분검사, 혈액검사, 복부 전산화 단층촬영 및 한방비만변증 (간울) 및 스트레스, 우울, 자존감 설문검사 결과의 상관성을 분석하였다. 본 연구는 경희대학교 동서신의학병원의 임상연구심사위원회의 승인을 받았다. 결과 : 1. 갱년기 비만여성에서 복부지방 면적, 피하지방 면적은 체질량지수, 체지방률, 허리둘레/신장비 등의 단순비만지표와 유의한 상관성을 보인 반면 (p < 0.01), 내장지방 면적은 단순비만지표와 상관성을 보이지 않았다. 2. 내장지방 면적은 사회 재적응 평가척도 (γ = 0.577, p < 0.01)와 유의한 상관성이 있었고, 선형회귀분석에서 유의한 결과를 나타냈다. VAT (cm2) = 116.1 + 0.101 x (SRRS score) (γ2 = 0.332) 3. 피하지방은 식이태도 점수와, 총복부지방은 식이태도 점수 및 갱년기지수 중 혈관운동증상과 상관성이 있었다. 4. 간울증은 스트레스 반응척도, 우울지수, 갱년기지수 및 그 하부항목 중 혈관운동, 정신, 운동, 소화, 전신증상과 양의 상관성을, 자존감척도와는 음의 상관성을 나타냈으며, 내장지방과 직접적인 상관성을 보이지 않았다. 결론 : 간울증은 높은 스트레스, 우울, 갱년기 증상 및 낮은 자존감과 관련되는 것으로 나타났다. 폐경전후 비만여성에서 내장지방 면적은 간울증과 유의한 상관성을 보이지 않았으나, 생활 스트레스 사건이 많을수록 높아지는 것으로 나타나 갱년기 여성 내장비만에서 스트레스에 대한 대처가 중요할 것으로 사료된다. 추후 임상적 연계성 및 설문 보완에 대한 연구가 필요하리라 생각된다.
  • 12.

    Comparative Study on Cupping Apparatuses for Medical Use by Mechanical Stability and Functional Test

    소문기 | Lim Hyung Ho | SONG YUN KYUNG | 2008, 18(2) | pp.157~167 | number of Cited : 6
    Abstract
    Objectives : It is sure that standardization of medical instruments is very important and necessary. Cupping therapy is one of the traditional oriental medical method, and it is necessary to set up a standard of cupping therapy and instruments. Methods : We select 3 major cupping instrument makers according to a questionnaire survey of 2001 oriental medical doctors. Dae Gun is A maker, Han Sol is B maker, Dong Bang is C maker. And with these air pumps we make experiments on stability by an inner impact test and a falling test. With these cups we check stability by an inner impact test and a disinfection test. And to know function of these instruments we test a negative pressure and maintain attached cups until 5 to 10minutes. Results : All results of experiments(impacted test, disinfection test, falling test) on stability of cups and air pumps are suitable for medical instrument. And the efficiency of 3 major makers shows various results. Negative pressure of B group is the highest, C group is the second, A group is the lowest. Pressure maintenance test shows A and C group is comparatively up to the experimental standard(<10%), B group is comparatively below the experimental standard(<10%). Conclusions : Results show stability of cups and air pumps is suitable for medical instruments. And negative pressure of cupping and maintenance of pressure show various results. So it is necessary to set up a standard negative pressure of cupping and maintenance of pressure.
  • 13.

    Literature Investigation Regarding Cupping Therapy and Analysis of Current Professional's Cupping Treatment

    이병이 | Lim Hyung Ho | SONG YUN KYUNG | 2008, 18(2) | pp.169~191 | number of Cited : 14
    Abstract
    Objectives : This study was performed to report the present situation of the cupping treatment to make standardization of cupping treatment in Korea. Methods : We searched relevant case reports, surveys, and review articles using a databases of online bibliography. And we had research to oriental medical doctor with questionnaire about the cupping treatment. Results : 1. Cupping treatment is used for diagnoisis, protection and treatment for many kinds of diseases such as musculoskeletal diseases, internal diseases, sequela of cerebral attacks and so on in Korea. 2. Adequate cupping area is the area of lesion. 3. Cupping time and pressure are various. 4. Adequate amount of venesection is 10cc. 5. Adequate dry cupping term is 1 time/day and adequate wet cupping term is 1 time/2~3days. 6. Cognition of adverse reaction of cupping treatment is different among the doctors. 7. Method of disinfection of cup is different among the doctors. Conclusions : The result of this study will help to make the a guideline of cupping treatment. And we have to go ahead studying to make standardization of cupping treatment.