KJC Korea
Journal Central

Objectives : Ohyaksungi-san(Wuyaoshunqi-san) has been used for many years as a treatment for cerebrovascular diseases in Oriental medicine. This study was designed to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san) on cognition and motor function recovery after ischemic brain injury, and also the expression of BDNF in hippocampus. Methods : This study was designed with 4 subgroups to evaluate the effects of Ohyaksungi-san(Wuyaoshunqi-san). As control groups, group Ⅰ has no treatment during 1 week after ischemic brain injury and group Ⅱ has no treatment during 2 weeks after ischemic brain injury. As experiemntal groups, group Ⅲ has been treated with Ohyaksungi-san(Wuyaoshunqi-san) during 1 week after ischemic brain injury and group Ⅳ have treated with Ohyaksungi-san(Wuyaoshunqi-san) during 2 week after ischemic brain injury. Each group has been examined by tests as follows, neurological motor behavioral tests, cognitive motor behavior test and histological test. Neurological motor behavior tests consisted of limb placement test, beam-walking test and horizontal wire test. Cognitive motor behavior test was performed by using Morris water maze. In the histological test, TTC(2,3,5-triphenylteterazolium chloride) staining, hematoxylin & eosin staining, and immunohistochemical staining were used. Results : 1. The tests for motor function recovery change had significantly good result in the experimental groups as compared with control groups(p<.05). 2. The Morris water maze test on cognition also had significantly good result in the experimental groups as compared with control groups(p<.05). 3. In the immunohistochemical staining for the expression of BDNF in hippocampus, more immune reaction was investigated in the experimental groups as compared with control groups. Especially group Ⅳ has the greatest immune reaction. Conclusions : Ohyaksungi-san(Wuyaoshunqi-san) has good effects on cognition and motor function recovery after ischemic brain injury, and also the expression of BDNF in hippocampus.

Objectives : It has been reported that CG was effective in decreasing injury to neural tissues. To investigate neural responses in the injured spinal cord, an extract of CG was examined to determine its effect on neural responses in the injured spinal cords of rats. Methods : After CG treatment was applied to the spinal cord of rats given a contusion injury, the re-growth responses of injured neural tissues and corticospinal tract axons was observed by measuring the number of GAP-43, Cdc2, and phospho-Erk1/2 proteins, CST axons, GFAP-stained astrocytes, and Glial scarring in the injured spinal cord. Results : Levels of GAP-43, Cdc2, and phospho-Erk1/2 proteins were found to have increased in the injured spinal cord region. The number of GFAP-stained astrocytes also increased within and around the injury cavity. Glial scarring, which was identified by CSPG immunofluorescence staining, was reduced by CG treatment. Anterograde tracing by DiI dye showed that the elongation of the CST axons in the dorso-medial white matter area was almost completely prevented at the injury site. Collateral sprouting was observed in the spinal cord rostrally close to the injury site, and CG treatment further increased axonal arborization in the corresponding region. In vivo migration of CST axons and astrocytes using an implanted polymer tube system showed more of an increase in enhanced migration of axons and astrocytes in CG-treated group compared to the injury control group. Conclusions : These results suggest that CG activated neural responses - including astrocyte migration - and promotes axonal regenerative activity in the injured spinal cord area.

Objectives : The aim of this study is to investigate Daesiho-tang(Dachaihu-tang) water extracts (DSTE) have potent anti-obesity activities in a high-fat diet-induced obesity mouse model. Methods : In this study, we designed three groups (normal diet group, high-fat diet group, high-fat diet plus DSTE group for 7-weeks oral administration). Results : Increases in body weight were inhibited by 7-weeks oral administration of DSTE at a 500 mg/kg concentration in this animal model. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by DSTE administration, also HDL-cholesterol was increased more than high-fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of DSTE were examined on the expression of the genes involved in lipogenesis by real-time PCR. In epididymal fat and liver of DSTE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the tissues weight. Conclusions : These results suggest that DSTE may have great potential as a novel anti-obesity agent.

Objectives : In oreder to investigate the effects of Soongijeseub-bang(Shunqichushi-fang)(here in after referred to SJB) on the obese gene and obese inhibitory, on C57BL/6 mice were induced by high fat diet. Methods : C57BL/6 mice were divided into three groups(normal, high fat diet with control, high fat diet with SJB extract) and fed for 15 weeks. And observed that, body weight change, final increase of body weight, the weight change of the adipocytes, the level change of ALT, AST, creatinine, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, NEFA, glucose, the expression of β3AR, leptin, and TNF-α gene in primary adipocytes and adipocytes tissue. Results : The following results were obtained in this study. 1. SJB 500 ㎎/㎏ extract group showed considerable decrease in weight, the final increase of weight and the amount of adipocyte in weight. 2. All experimental group showed that the amount of ALT, AST, total cholesterol, LDL-cholesterol, triglyceride and NEFA were decreased considerably. SJB 500 ㎎/㎏ extract group showed the amount of HDL-cholesterol and leptin were increased considerably. 3. All experimental group showed that the revelation of β3AR in primary adipose cell and 3T3-L1 cell were increased considerably, and that the revelation of leptin in primary adipose cell and 3T3-L1 cell were decreased considerably. SJB 100 ㎕/㎖ extract group showed that the revelation of TNF-α were decreased considerably. 4. SJB 500 ㎎/㎏ extract group showed that the size of adipocyte in adipocytes tissue were decreased. 5. All experimental group showed that the adipose vacuoles in liver tissue were decreased considerably. Conclusions : Comparison of the results for this study showed that SJB is effective on obesity care and has obese-inhibitory effects in obese mouse induced by high fat diet. So it is respected that the clinical application of SJB can help the treatment of obesity.

Objectives : The purpose of this study is to find out the effects of kinesio taping on nuchal pain caused by traffic accidents. Methods : The 40 patients were divided into 2 groups : Group A was treated except taping and Group B was treated with taping. Both Group were treated with Acupunture, Phy-Tx and Herb-med. Patients were evaluated and analyzed Visual Analog Scale(VAS), Pain Rating Score(PRS) and Neck Disability Index(NDI). Results : 1. Group B was significantly decreased in VAS, NDI after 3 days of treatment. 2. Group B was significantly decreased in PRS after 6 days of treatment. 3. Group A was significantly decreased in VAS, PRS and NDI after 9 days of treatment. 4. Group B compared with the Group A was decreased in VAS and NDI after 12 days of treatment. 5. Group B compared with the Group A was significantly decreased in PRS after 9 days of treatment. Conclusions : We found out that kinesio taping treatment is considered to be effective and useful on nuchal pain caused by traffic accidents.

Objectives : The purpose of this study was to identify the effect of electro-acupuncture stimulation regarding restoration of range of motion on patients with frozen shoulder. Methods : Experimental group measured with shoulder flexion and abduction angle at pre and post electro-acupuncture stimulation. Results : There were statistically significant difference regarding change of flexion angle of electro-acupuncture stimulation(p<0.01) and the testing value of all levels had a significant difference with the value of final post-test(p<0.01). There were statistically significant difference regarding change of abduction angle of electro-acupuncture stimulation(p<0.01). Conclusions : Electro-acupuncture stimulation of distal part increased range of motion of frozen shoulder. Therefore, application of electro-acupuncture should be developed as a therapeutic method in treatment of frozen shoulder. Also, it can contribute as one of good therapeutic methods offered to patients through approach of oriental rehabilitation medicine.

Objectives : The purpose of this study is to evaluate flexor-extensor muscle strength of trunk according to Sasang constitution. Methods : This study was carried out with the data from comprehensive medical testing. People were performed Trunk Extension Flexion(TEF) Program of CYBEX NORM System and QSCC(Questionnaire of Sasang Constitution Classification) II test. And then we made three groups according to Sasang constitution and analyzed isokinetic strength on the TEF. Results : 1. A significant difference(Taeumin>Soeumin>Soyangin) was found in flexor muscle peak torque(PT) of trunk according to Sasang constitution(P<0.05). 2. A significant difference was not found in flexor muscle peak torque%body weight(PT%BW) of trunk according to Sasang constitution. 3. A significant difference(Taeumin>Soeumin>Soyangin) was found in extensor muscle peak torque(PT) of trunk according to Sasang constitution(P<0.05). 4. A significant difference(Soeumin>Taeumin>Soyangin) was found in extensor muscle peak torque%body weight(PT%BW) of trunk according to Sasang constitution(P<0.05). Conclusions : There is a significant difference in isokinetic strength on the TEF according to Sasang constitution.

Objectives : This study aimed to understand the satisfaction degree of patients due to traffic accident(TA) in order to provide basic data which would give help not only to improve the quality of services, but also to strengthen the competitiveness of oriental medical hospitals on sequela of TA patients. Methods : The data were collected from inpatients and outpatients who answered a self-report questionnaire. Independent t-test, analysis of variance(ANOVA), X2-test, correlation analysis were used for data analysis. Results : According to the research on medical satisfaction degree, the overall satisfaction degree was 4.141. On each field, satisfaction degree related to the doctor service recorded the highest degree among others(4.474). Satisfaction degree related to the appropriateness of service was the second(4.091). On the other hand, satisfaction degree of using procedure was the lowest degree(3.857). On the difference of degrees of satisfaction by general characteristics, patients who were unemployed․houseworker group showed lower doctor service satisfaction degree than that of other groups. However, on the difference of degrees of satisfaction related to other general characteristics, there were no signigicant differences(p<0.05). Conclusions : The service distribution of oriental medical hospital was almost equal without concentrating on specified social classes.

Objectives : The purpose of this study was to know the characteristics of Skin Resistance Variability(SRV) in the traffic accident patients prescribed Dangkisoo-san(Dangguixu-san). Methods : 65 traffic accident patients were selected from those who took the Skin Resistance Variability(SRV) test in Oriental Medical Hospital of Sang-Ji University from March 2007 to January 2008. The traffic accident patients were prescribed Dangkisoo-san(Dangguixu-san). Mean values of factor AA on skin resistance variability of the traffic accident patients were analyzed. Results and Conclusions : The mean values of electrodermal activity of preexamination was higher than those of postexamination in all areas except 3 area in 2nd measurement. In most cases, the gap of electrodermal activity between preexamination and postexamination within the female group was higher than those of the male group. In most cases, the gap of electrodermal activity between preexamination and postexamination within the more than 21 days group was higher than those of the 20days and less group. In most cases, the gap of electrodermal activity between preexamination and postexamination within the 36 years old group was higher than those of the 35years old and less group. Dangkisoo-san(Dangguixu-san) will be more effective for acute and strong traffic accident patients than chronic and weak traffic accident patients. So, further studies will be needed.

Objectives : The aim of this study was to observe and analysis the effectiveness of clinical treatments on the growth of children treated with Korean herbal medicine (KHM). Methods : Forty-two children of growth retardation were evaluated from January 2007 to May 2008. All children were administered KHM with diet and exercise guidance. Height percentile and predictive height were calculated following the General Growth Statistics Result (2007), and compared those of pre-treatment with post-treatment. Results : Thirty-one of them were improved (73.8%) and eleven were not (26.2%). The mean growth rate was 7.2cm/yr for male and 6.8cm/yr for female. The mean growth percentile of male showed 7.6% improvement (p=0.003), female 4.4% respectively (p=0.036). The mean predictive height of male showed 2.2cm improvement (p=0.005), female 1.0cm respectively (p=0.007). Change of growth percentile and predictive height were significantly higher on period of prepuberty, and in small children below 50% of height percentile. About inter-relations between growth improvement and compliance of diet, exercise or medication, meaningful statistics were shown in diet control than the others (p=0.077). Diet compliance was in close connection with exercise, but others were not shown close correlations. Conclusions : These results showed that KHM showed promising results on children growth and healthy diet would be an important factor for growth of children. And it was recommended that KHM should be applied on period of prepuberty and smaller than average height.

Objectives : Oriental Medicine Music Therapy is a new way of treating and preventing various diseases and promoting health by means of music specially picked and designed to produce Qi(氣) fitting to an individual person in the areas of the structure of human body, physiological function, pathological change, diagnosis and treatment. Therefore, it can facilitate the efficiency of the treatment much better and faster than only with herb or acupuncture. Equilibrium between body and mind is its originality. Methods : A 38-year old man came to hospital suffering from left side weakness, dysarthria because of cerebral infarction. After one week's medication in the part of neurology, he was sent to the oriental medicine music therapy center, and he took ten times' medical treatments once a day. Before and after the treatments, implementing 'Ink foot print analysis', as for the movement capacity and walking of left side weakness, these results are acquired. Results and Conclusions : 1. Before the oriental medicine music therapy, except the acceleration and deceleration section, within three meters, a right foot's step was measured 30.55 cm and a left foot was measured 15.2 cm, and the step distance was 15.2 cm. After the 10 times treatments, the right foot's step was 112.6 cm, the left foot's step was 113 cm, and the step distance improved to 51.8 cm. 2. The normal person's average step is about 38 cm, and it could be decreased owing to a decreptitude, pain, fatigue, and the weakness of the legs. In spite of all, from the increased 50 cm step measurement with the patient's body condition, it means that his movement capacity is recovered. 3. In the measurement of walking time, before 10 times treatments, it took 46.35 seconds within 6M, but after the treatments, it increased to 7.47 seconds as same as a normal person's walking speed. 4. In insomnia, and the abnormality of a facial muscle, it shows lots of improvement, and even the accuracy of a pronunciation, but despite of the 10 times treatments, the 'ㄹ(r)‘ sound placed under a vowel is unclear. 5. Before the 10 times' treatments, he can move the left side shoulder with pain and cannot move below the left elbow. After the treatments, the pain was disappeared, and he was able to move over 60 cm without pain. And improving of the movement of fingers, he can beat over 8 times with a drumstick.

Objectives : To report one case of semi-coma patient was treated by scalp acupuncture with electric stimulation. Methods : Patient (state of semi-coma) was treated by scalp acupuncture with electric stimulation, herbal medication and physical therapy. The improvement of patient was measured every other week by Glasgow Coma Scale(GCS), Modified Bathel Index(MBI), National Institutes of Health Stroke Scale(NIHSS). Results : We observed the patient decrease in NIHSS score and increase in GCS and MBI. Symptoms of patient such as semi-coma were improved following the treatment. Conclusions : It is suggested that oriental medical treatment; scalp acupuncture with electric stimulation, herbal medication and physical therapy were effective in semi-coma caused by traumatic brain injury.

Objectives : This study is designed to evaluate the effectiveness of muscle energy techniques and acupuncture therapy on patients with idiopathic lumbar scoliosis. Methods : We have investigated 3 patients with idiopathic lumbar scoliosis, used muscle energy techniques and acupuncture therapy, measured Cobb's angle before and after treatment. Results : After treatment, One case, the L-spine Cobb's angle correctability was 62.74%, another case was 34.66%, the other case was 45.50%. Conclusions : These results suggest that muscle energy techniques and acupuncture therapy was effective treatment on patients with idiopathic lumbar scoliosis.

Objectives : The purpose of this study is to report the concept of familial scoliosis through eight cases. Methods : The family tree was constructed with eight cases which was diagnosed idiopathic scoliosis by physical examination and radiological study. Results : According to the family tree of this sibs, idiopathic scoliosis apparently behaves as an autosomal dominant inheritance. As to parents and grandparents, although they are not confirmed the appearance of idiopathic scoliosis, we know that they transmit trait to their descendants as a genotype. Conclusions : This study is shown that idiopathic scoliosis has a familial condition and provided useful information that can be used early diagnosis and treatment with screen tests based on the family tree.

Objectives : This report was performed to evaluate the treatment of acupuncture therapy, Bee venom acupuncture therapy and herbal medication in Baastrup's disease. Methods : We treated 1 case of Baastrup's disease with acupuncture therapy, Bee venom acupuncture therapy one times a week and took herbal medicine after a meal two times daily. The patients` symptoms were assessed 3 month, 6 month, 9 month by Visual analogue scale(VAS), Oswestry disability index(ODI). Results : Visual Analog Scale(VAS), Oswestry Disability Index(ODI) was significantly improved after treatment for 9 months Conclusion : This study suggested that acupuncture therapy, Bee venom acupuncture therapy and herbal medicine can be effective for decreasing pain and improving functional recovery. We think that it need the further study and clinical trial for Baastrup's disease.

Objectives : The purpose of this study is to evaluate the clinical effect of acupuncture and electroacupuncture by meridian theory to a patient with writer's cramp. Methods : We treated this patient with only acupuncture and electroacupuncture by meridian theory. We evaluated the state of improvement by time to maintain right 2nd finger extended, Pain Disability Index(PDI). PDI was measured twice before treatment and after 19 weeks. Results and Conclusions : The subject was improved in estimation by time to maintain right 2nd finger extended, PDI. The time was from a few seconds to almost 90 minutes. PDI was from 21 to 17. According to above result, acupuncture and electroacupuncture by meridian theory were effective to improve symptoms of writer's cramp.

Objectives : This study was designed to evaluate the effects of oriental medical treatments on the patient with agitation accompanied constipation. Methods : One patient was admitted who was constipation, agitation, headache, chilling sign, thirst, heat, nausea, insomnia. The patient was diagnosed as constipation and agitation that was caused by heat in the heart and alimentary tract, and was treated with herb-medication, acupuncture, moxa therapy, anal therapy and aroma therapy for about 4 months. And then, we investigated and analyzed the clinical symptoms of the patient. Results : Most of all the clinical symptoms related with agitation accompanied constipation were improved gradually after oriental medical treatments. Conclusions : From the above results, it could be suggested that oriental medical treatments have good effects on agitation and constipation. And it will be necessary to extensively research and develop oriental medical treatments for this disease.