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2012, Vol.22, No.1

  • 1.

    Acute Toxicity of Fermented Deer Velvet Antler Extract in ICR Mice

    Chung Won Suk | Kim Sung-Soo | oh jaekeun and 5other persons | 2012, 22(1) | pp.1~10 | number of Cited : 0
    Abstract
    Objectives :The aim of this study was to investigate the acute toxicity and safety of fermented deer velvet antler extract in institute for cancer research(ICR) mice. Methods : To evaluate the acute toxicity and safety, fermented deer antler at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg were given orally to 25 male ICR mice for 14 days and allocated 5 mice for each group. After a single administration of fermented deer antler extract, we observed survival rates, general toxicity and any changes in body weight. Autopsies were conducted on all 25 mice. Results : Compared with the control group, we did not find any toxic alterations in any of the treated groups. Conclusions : A single dose of 5000 mg/kg of fermented deer antler extract was found to be safe in ICR mice. However, anything beyond this level has the potential to be lethal.
  • 2.

    Anti-fatigue Effect of Fermented Deer Velvet Antler Extract in Sprague-Dawley Rats

    Chung Won Suk | Kim Sung-Soo | oh jaekeun and 5other persons | 2012, 22(1) | pp.11~22 | number of Cited : 2
    Abstract
    Objectives :The aim of this study was to investigate the Anti-muscle fatigue effect of fermented deer velvet antler extract in Sprague-Dawley rats. Methods : Rats were randomly divided into four groups of 10 mice each according to a randomized block design. Saline solution was orally administered to the control group, 100 mg/kg of water-extract of deer velvet antler to the positive control group, 50 mg/kg of fermented deer velvet antler extract to experimental group 1 and 100 mg/kg of fermented deer velvet antler extract to experimental group 2. Each of the four groups were treated for seven days and then participated in a forced swimming test which applied both a high intensity exercise model and a prolonged exercise model. We observed swimming times and examined blood biochemical parameters. Results : In the high intensity exercise model, the effect of the deer velvet antler was seen in the increased swimming times. Experimental group 2 swam for approximately 600% longer as compared to the control group(p<0.001), indicating that the recovery effect is dose-dependent. In the forced swimming tests using the prolonged exercise model, blood sugar levels(p<0.001) and free fatty acid levels(p<0.05, p<0.01 each) in the positive control group and experimental groups 1 and 2 demonstrated a significant recovery effect in comparison with the control group. Conclusions : Fermented deer velvet antler extract may have an Anti-muscle fatigue effect similar to that of deer velvet antler extract and could be used when it has an effect equal to one-fifth of the amount considering the yield rate.
  • 3.

    Suppressive Effects of Imyo-san on Freund's Complete Adjuvant(FCA)-induced Arthritic Rats

    배병찬 | 최은실 | 권오곤 and 2other persons | 2012, 22(1) | pp.23~42 | number of Cited : 5
    Abstract
    Objectives :The object of this study is to observe the favorable anti-arthritic effects of Imyo-san(Èrmiào-sǎn)(IMS), that has been traditionally used in Korean medicine to treat rheumatoid arthritis, on Freund’s complete adjuvant(FCA)-induced arthritic Wistar rats. Methods :Rheumatoid arthritis was induced by intradermal injection of FCA(10 mg in 1 ml paraffin oil 0.1 ml/rats). Each of 8 rats showing regular ankle thicknesses, per group selected after 14 days after FCA treatment to confirm the induction of rheumatoid arthritis. 300, 150 or 750 mg/kg of IMS were orally administered once a day for 14 days from 14 days after FCA treatments. Dexamethasone was intraperitoneally administered 15 mg/kg, once a day for 14 days from 14 days after FCA treatments. Experimental animals were sacrificed after 14 days of continuous oral treatment of IMS or intraperitoneal administration of dexamethasone, and changes on the body weight, knee circumferences, gross arthritis score, inflammatory tissue prostaglandin(PG) E2 level sand cartilage collagen, glucosaminoglycans compositions–chondroitin sulphate, heparan sulphate and hyaluronic acid in the present study. Results :As results of FCA treatment, classic rheumatoid arthritis featuring dramatical decreases on the body weight, cartilage collagen contents and bone glucosaminoglycans - chondroitin sulphate, heparan sulphate and hyaluronic acid contents, with increases on the knee circumferences, gross arthritis scores and inflammatory tissue PGE2 levels. However, these changes from FCA-induced rheumatoid arthritis were clearly reduced by treatment of dexamethasone and both two different dosages of IMS, 300 and 150 mg/kg in the present study. Although FCA-induced arthritis were more favorably inhibited by treatment of dexamethasone 15 mg/kg as compared with IMS 300 mg/kg, marked decreases of body weights were detected in dexamethasone 15 mg/kg treated rats. Conclusions :The results obtained in this study suggest that over 150 mg/kg of IMS showed favorable anti-arthritic effects on the FCA-induced arthritis mediated by suppression of PGE2. However, detailed mechanism studies should be carried out in future with the screening of the biological active compounds in this herb. Although FCA-induced arthritis were more favorably inhibited by treatment of dexamethasone 15 mg/kg as compared with IMS 300 mg/kg, marked decreases of body weights were detected in dexamethasone 15 mg/kg treated rats, in the present study.
  • 4.

    A study on the History and Transmission of Bone-arrangement Therapy in Korea and Its Clinical Usage

    Jeon Jong Wook | 임보경 | Jeong-Hwa Lee and 1other persons | 2012, 22(1) | pp.43~57 | number of Cited : 2
    Abstract
    Objectives :The aim of this study is to investigate into the origin, transmission and transformation of traditional therapy called JieGu(接骨) in Korea and to present the status of JieGuShi(接骨士) in Korea in contrast to Japan and China. Methods :We searched medical or non-medical classics of Joseon dynasty with the key word “JieGu(接骨)” and found various therapies for bone fracture and dislocation. And we analysed JieGuShi exam books in Japanese imperialistic period, and made interview with Korean JieGuShi remained. Results :We found considerable linkage of clinical technique for bone fracture and dislocation which is using drugs, surgery and hand techniques in spite of centennial time gap. But the JieGuShi system is about to disappear because of institutional change in medicine and the techniques they had also distributed quite a lot without formal successors. In contrast, Japan’s JieGuShi who succeeded to merge the traditional technique and modern medicine in musculoskeletal field are now much flurishing. Conclusions :The linkage of traditional JieGu technique and succeeding modern clinics in Korea is evident. The imminent task is registering the original practices of JieGuShi which is to be selected and arranged to revitalize the skills of hand therapies in the musculoskeletal field.
  • 5.

    Statistical Errors of Articles Published in the Journal of Oriental Rehabilitation Medicine (Ⅱ)

    Tae-Yong Park | 허태영 | Youn-Seok Ko and 2other persons | 2012, 22(1) | pp.59~73 | number of Cited : 2
    Abstract
    Objectives :The purpose of this study was to introduce clinicians and researchers to the statistical errors detected in the Journal of Oriental Rehabilitation Medicine (JORM), and to improve the quality of newly-publishing papers in JORM. Methods :We reviewed 222 articles published in the JORM from January 2005 to October 2009, excluding 74 articles in which statistical analysis was not used. Several statistical errors including an inaccurate post-hoc test, an inappropriate description of statistics program, an improper interpretation of statistical results, an inappropriate use of statistical terminology, and an invalid statistical methodology were investigated using our checklist. Four researchers participated in the statistical evaluation to minimize the biases. Results :1. Thirteen articles(6%) had an inaccurate post-hoc test. 2. Forty six articles(21%) had the inappropriate or omitted descriptions of statistics program. 3. Sixteen articles(7%) didn't have full explanation of the statistic method in the body of paper. 4. Twenty two articles(10%) had no description of statistical methods although each of authors mentioned the usage of statistical methods in the body of paper. 5. There were 135 articles(63%) having inappropriate descriptions of the statistical terminology. Conclusions :Various mistake or misuse of the methodology applications in the articles published in the JORM was found out. A correct application of statistic to the articles and a active participation of the statistical specialists at the beginning of study design were needed to improve the quality of JORM.
  • 6.

    The Comparative Study on the Effect of Pharmacopuncture Treatment and Chuna Treatment for Neck Pain Caused by Traffic Accidents

    이재훈 | 김준수 | 양기영 and 3other persons | 2012, 22(1) | pp.75~83 | number of Cited : 13
    Abstract
    Objectives :The purpose of this study is to compare the effect of pharmacopuncture treatment with chuna treatment for neck pain caused by traffic accidents. Methods :This study was carried out on the 82 patients with neck pain caused by traffic accidents. The patients were divided into 2 groups; Pharmacopuncture(PA) group was treated by pharmacopuncture treatment. Chuna(CN) group was treated by chuna treatment. Also both groups treated by general acupuncture and herb-medicine treatment. We measured visual analog scale(VAS) before the treatment and 2, 4 weeks later. Also neck disability index(NDI) measured before the treatment and 4 weeks later. Results :In results, NDI and VAS scores were improved after 4 weeks later in both groups. There were no significant difference between NDI and VAS scores after 4 weeks later in both groups. However, in the second period(from 2 to 4 weeks treatment) CN group showed significant diffrence as compared to PA group in VAS scores. Conclusions :In this study, there were no significant difference between pharmacopuncture treatment and chuna treatment for neck pain caused by traffic accidents. However, in the second period(from 2 to 4 weeks treatments) chuna treatment was more effective than pharmacopuncture treatment for neck pain by traffic accidents.
  • 7.

    The Clinical Study of Effect of Balneotherapy on Cervical Pain

    최보미 | 박지현 | 홍서영 | 2012, 22(1) | pp.85~95 | number of Cited : 4
    Abstract
    Objectives :The purpose of this study was to investigate the effect of balneotherapy on cervical pain. Methods :50 cervical pain patients participated in this study. Each participant took 1 session of balneotherapy which consisted of 15 minutes of high pressure underwater shower(32~36 ℃) and another 15 minutes of whole body bathing(32~40 ℃). VAS and pain threshold were measured before and after the whole session. Then the results were analysed. Results :1. The average of VAS significantly decreased by 3.706±9.072: 6.786±9.216 before treatment to 3.080±1.830 after treatment(p<0.01)(Table Ⅳ). 2. The average of pain threshold significantly increased by 1.228±2.053 lbf: 9.286±3.289 lbf before treatment to 1.228±2.053 lbf after treatment(p<0.001) (Table Ⅳ). Conclusions :These results suggest that balneotherapy may have clinical effects on cervical pain and also imply that it could be an alternative and complementary treatment to other musculoskeletal diseases. Further studies are needed to figure out the effects of balneotherapy on various diseases and we expect balneotherapy could gain ground on the oriental physical therapy.
  • 8.

    The Clinical Study of Effect of Balneotherapy on Low Back Pain

    신재화 | 박지현 | TaekWon ahn and 1other persons | 2012, 22(1) | pp.97~108 | number of Cited : 6
    Abstract
    Objectives :The purpose of this study was to investigate the effect of balneotherapy on low back pain. Methods :50 low back pain patients participated in this study. Each participant took 1 session of balneotherapy which consisted of 15 minutes of high pressure underwater shower(32~36 ℃) and another 15 minutes of whole body bathing(32~40 ℃). VAS(visual analogue scale) and pain threshold were measured before and after the whole session. Then the results were analysed. Results :1. The average of VAS significantly decreased by 2.036±1.475: 4.800±2.068 before treatment to 2.764±1.858 after treatment(p<0.001)(Table Ⅳ). 2. The average of pain threshold significantly increased by 1.966±3.741 lbf: 11.108±4.735 lbf before treatment to 13.074±5.313 lbf after treatment (p<0.05)(Table Ⅳ). Conclusions :These results suggest that balneotherapy may have clinical effects on lumbar pain and also imply that it could be an alternative and complementary treatment to other musculoskeletal diseases. Further studies are needed to figure out the effects of balneotherapy on various diseases such as other musculoskeletal diseases.
  • 9.

    The Clinical Study of Balneotherapy by DITI

    Jung-Min Lee | In-Sun Park | TaekWon ahn and 1other persons | 2012, 22(1) | pp.109~118 | number of Cited : 3
    Abstract
    Objectives :The purpose of this study was to investigate the influence of balneotherapy on the changes of DITI(digital infrared thermal imaging). Methods :This study was carried out on 27 patients. They went through balneotherapy with high pressure under water shower(15 min.) and whole body bathing in neutral or hot water between 32 to 40 ℃(15 min.). DITI was measured at before and after the treatment. And then the data was analyzed. Results :1. In cold hypersensitivity of hands group, temperature on PC8 rose and difference between LU4 and PC8 decreased(p<0.05)(Fig. 1, Table Ⅱ). 2. In cold hypersensitivity of feet group, temperature on LR3 rose and difference between ST32 and LR3 decreased(p<0.05)(Fig. 2, Table Ⅱ). 3. In shàngrèxiàhánzhèng(上熱下寒證) group, there were no significant changes on CV17, CV6 and difference between CV17 and CV6(Fig. 3, Table Ⅱ). Conclusions :These results demonstrated that balneotherapy has clinical effects on cold hypersensitivity of hands and feet. And further studies are required to apply the balneotherapy in order to cure various diseases in the future.