KJC Korea
Journal Central

Objectives The object of this study was to observe the favorable anti-arthritic effects ofSamki-eum (sānqì-yǐn) on Freund’s complete adjuvant (FCA)-induced arthritic Wistar rats. Methods Rheumatoid arthritis was induced by intradermal injection of FCA, and 300,150 or 750 mg/kg of Samki-eum (sānqì-yǐn) were orally administered once a day for 14days from 14 days after FCA treatments, and 15 mg/kg of dexamethasone was intraperitoneallyadministered as reference drug in this experiment. All rats were sacrificed at14 days after continuous oral treatment of Samki-eum (sānqì-yǐn) or intraperitoneal administrationof dexamethasone, and changes on the body weight, knee circumferences, grossarthritis score, inflammatory tissue prostaglandin (PG) E2 levels were monitored with cartilagecollagen components and glucosaminoglycans compositions - chondroitin sulphate,heparan sulphate and hyaluronic acid in the present study. Results As results of FCA treatment, classic rheumatoid arthritis featuring dramaticaldecreases on the body weights, cartilage collagen contents and bone glucosaminoglycans-chondroitin sulphate, heparan sulphate and hyaluronic acid contents, with increaseson the knee circumferences, gross arthritis scores and inflammatory tissue PGE2 levels. However, these changes from FCA-induced rheumatoid arthritis were clearly reduced bytreatment of dexamethasone and both two different dosages of Samki-eum (sānqì-yǐn)300 and 150 mg/kg in the present study. Although FCA-induced arthritis were more favorablyinhibited by treatment of dexamethasone 15 mg/kg as compared with Samki-eum(sānqì-yǐn) 300 mg/kg, marked decreases of body weights were detected in dexamethasone15 mg/kg treated rats, and Samki-eum (sānqì-yǐn) 300 mg/kg showed similarpreserve effects on the cartilage glucosaminoglycan compositions in this study. Conclusions The results obtained in this study suggest that over 300 and 150 mg/kg ofSamki-eum (sānqì-yǐn) showed favorable anti-arthritic effects on the FCA-induced arthritismediated by suppression of PGE2, a inflammatory mediator. However, detail mechanismstudies should be conduced in future with the screening of the biological active compoundsin this herb. Although overall anti-inflammatory effects Samki-eum (sānqì-yǐn) 300mg/kg were lowered than those of dexamethasone 15 mg/kg treated rats, Samki-eum(sānqì-yǐn) 300 mg/kg treated rats showed similar preserve effects on the cartilage glucosaminoglycancompositions in this experiment.

Objectives The aim of this study was to investigate antimicrobial activity of Huanggeumjakyak-tang water extract against MRSA. Methods The antibacterial activities of Huanggeumjakyak-tang were evaluated against3 strains of Methicillin-resistant Staphylococcus aureus (MRSA) and 1 standard MethicillinsusceptibleS. aureus (MSSA) strain by using the disc diffusion method, minimal inhibitoryconcentrations (MICs) assay, colorimetric assay using MTT test, checkerboard dilutiontest and time-kill assay was performed under dark. Results The MIC (minimum inhibitory concentration) of Huanggeumjakyak-tang waterextract against S. aureus strains ranged from 1,000 to 2,000μg/ml. So we confirmed thatit has a strong antibacterial effect. Also the combinations of Huanggeumjakyak-tang waterextract and conventional antibiotics exhibited improved inhibition of MRSA with synergyeffect. Conclusions The results obtained in this study suggest that Huanggeumjakyak-tangwater extract showed antibacterial effect against MRSA, and it also showed reducing effecton the side-effect problems that are the major weak points of traditional antibiotics.

Objectives The aim of this study was to investigate anti-inflammatory activity ofMugi-hwan (MGH) Water Extract. Methods Cells were treated with 2 ug/ml of LPS 1 hour prior to the addition of MGH. Cell viability was measured by MTS assay. The production of NO was determined by reactingcultured medium with Griess reagent. The expression of COX-2, iNOS and MAPKswas investigated by Western blot, RT-PCR. The content of level of cytokines (PGE2, IL-6,in media from LPS-stimulated Raw 264.7 cells was analyed by ELISA kit. Results MGH inhibited the production of NO, PGE2, IL-6 as well as the expressions ofiNOS, COX-2 in the murine macrophage, RAW 264.7 cells. MGH also had suppression effectsof LPS induced MAPKs activation. Conclusions These results suggest that MGH has an anti-inflammatory therapeutic potential,which may result from inhibition of MAPK phosphorylation, thereby decreasing theexpression of pro-inflammatory genes.

Objectives The present study was designed to investigate the effects of bee venom extractpharmacopunctureon (BVP) at 肩井 (GB21) on the changes in regional cerebral bloodflow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determinethe mechanisms. Methods We purchased rats about 300g and prepared diluted BVP with normal saline. And we injected diluted BVP to rats gradually progressed from 0.001 mg/kg to 0.1 mg/kgat corresponding region to GB21. After injection, we measured the changes in rCBF andMABP of rats. In addition, to determine the mechanisms of this changes, we did the sameexperiments twice more after pretreatment with indomethacin and metylene blue separately. Results BVP significantly increased rCBF but decreased MABP, suggesting that BVPpotently may increase rCBF by dilating pial arterial diameter. Furthermore, the increase ofBVP-induced rCBF and the decrease of BVP-induced MABP were significantly blocked bypretreatment with cyclooxygenase inhibitor, indomethacin (1 mg/kg, i.p.). But the increaseof BVP-induced rCBF and the decrease of BVP-induced MABP were not blocked by pretreatmentwith guanylate cyclase inhibitor, methylene blue (0.01 mg/kg, i.p.). Conclusions These findings indicate that the action of BVP is mediated by cyclooxygenase. Furthermore these results suggest that BVP can increase rCBF in normal state, aswell as improve the stability of rCBF in ischemic state.

Objectives The objective of present study was to investigate the effect of Ojeoksangamibang(Wǔjīsǎnjiāwèifāng) extract on recovery of liver function in carbontetrachloride(CCl4)-exposed rat. Methods Male rats weighing 230±7.21 g fed experimental diet for 1 week and 28 ratswere divided into 4 groups. Each of 7 rats was devided into a control group and experimentalgroups. We fed a control group of rats a basal diet and administered normalsaline (100 mg/kg, 1 time/1 day) for 3 weeks. And we fed each experimental group of ratsbasal diet and administered an extract of Ojeoksangamibang extracts (100 mg/kg, 200mg/kg, 300 mg/kg, 1 time/1 day) for 3 weeks. We measured lipid of plasma and liver, concentrationof proinflammatory cytokines (IL-1β, TNF-α, IL-6 and IL-10). Statistical analysiswas done by one-way analysis of variance (ANOVA) and Duncan's multiple range testwith significance level at p＜0.05. Results Plasma a-fetoprotein (AFP) and total protein concentration showed a tendencyto decrease in Ojeoksangamibang extract-treated groups. However, plasma albumin concentrationshowed no significant differences in all treatment groups. Activity of plasmaAspartate aminotransferase (AST) and Alanine aminotransferase (ALT) in the Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extractstended to decline. Alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and γ-glutamyltransferase (γ-GT) activities showed a tendency to decrease in Ojeoksangamibangextract-treated groups, increased addition amount of Ojeoksangamibang extracts tendedto decline. Concentration of plasma triglyceride and total cholesterol showed a lower valuethan that of control group. The liver IL-1β, IL-6 and TNF-α concentration were decreased,and IL-10 was increased in Ojeoksangamibang extract groups, compared tocontrol group. Plasma IL-1β, IL-6 and TNF-α concentration were decreased, and IL-10was increased in Ojeoksangamibang extract groups, compared to control group. Conclusions This study suggested that Ojeoksangamibang may alleviate liver inflammatoryreaction induced by liver toxicity.

Objectives This study was to investigate the effects of Yuhyangjeongtong-san on thecarrageenin-induced acute inflammation and adjuvant-induced arthritis in rats. Methods Acute inflammation was induced by injection of 2% carrageenin 0.15 ml intoright hind foot of rats. Control group was carrageenin injected and taken distilled water,treated group was carrageenin injected and taken Yuhyangjeongtong-san by orally once. 2 hours after injection, plantar temperature and paw volume were measured. 3 hours after,counts of white blood cell (WBC) were performed. Arthritis was induced by injection ofcomplete freund’s adjuvant (CFA) into base of tail. Control group was CFA injected andtaken distilled water, treated group was CFA injected and taken Yuhyangjeongtong-san byorally for 10 days. 0,5,10 day, body weight, thickness of ankle joint and paw edema weremeasured. 10 day, counts of WBC, interleukin-1β (IL-1β) and tumor necrosis factor-α(TNF-α) level were analysed. Histochemical study of NADPH-d and immunohistochemicalstudy of c-fos were performed. Results In the carrageenin-induced acute inflammation, neutrophils of treated groupwere significantly decreased compared with control group. In the adjuvant-induced arthritis,paw edema, total counts of WBC and TNF-α level in paw exudates were significantlydecreased compared with control group, and the number of c-fos positive neurons oftreated group was significantly decreased compared with control group. Conclusions On the basis of these results, we concluded that Yuhyangjeongtong-sanhave anti-arthritic and anti-inflammatory effects.

ObjectivesThe purpose of this study was to investigate the effectiveness of the Gongjin-dan (Gongchen-dan, here in after GJD) in order to obtain the evidence for clinical application. MethodsThe GJD-related articles published from 1990 to 2013 were searched using “Korean Traditional Knowledge Portal”, “Oriental Medicine Advanced Searching Integrated System (OASIS)”, “Korean Association of Medical Journal Edition (Koreamed)”, “Research Information Services (RISS4U)”, “Korean Medicine Database (KMbase)”, “National Discovery for Science Leader (NDSL)”, “PubMed”, “China National Knowledge Infrastructure (CNKI)”. The search keywords were “Gongjin-dan”, “Gongchen-dan”. Thirty-nine articles were obtained. After excluding the eighteen article which did not meet inclusion criteria, finally twenty-one articles were included; five clinical articles and sixteen experimental articles. ResultsIn clinical studies, GJD has the various effectiveness in cardiovascular diseases, alcoholic hepatitis, mild dementia, anemia. Also experimental studies related to the GJD show a variety of effects, such as anti-oxidative activity, neuroprotective activity, hepatoprotective activity, anti-inflammatory activity, immunological activity, reproductive recovery activity with fewer side-effects. ConclusionsIt has been suggested that there are various effects of GJD in treating a wide-range disease. However, in order to put GJD to use for many kinds of diseases in more reasonable ways, it is needed to publish well-design clinical trial based on the variety of results of experimental studies. (J Korean Med Rehab 2013;23(3):69-78)

Objectives The aim of this study was to investigate pelvic insufficiency and its correlationwith lumbago side. Methods 72 cases of patients who received treatment from March 2010 to February2013 for lumbago were analyzed. Their pelvic insufficiency parameters were estimated byx-ray analysis and lumbago sides were considered. The data were analyzed to find outcorrelation of pelvic insufficiency parameters and correlation between parameters andlumbago sides. Pearson correlation and two-by-k cross tabulation analysis were used. Results 1) Iliac height difference had significant correlation with femur height differenceand the result was alike previous studies' results. 2) Femur height difference and iliacheight difference had no significant correlation with iliac width difference. 3) Posterior rotationmalposition ilium side and inflare side had no significant correlation with lumbago side. Conclusions Iliac height difference had significant correlation with femur height differenceand sides of pelvic insufficiency had no significant correlation with lumbago sides.

Objectives We will provide basic information on bee venom clinical tests and aid thepractical use of bee venom in such tests, through examination of RCT research related tobee venom that was reported domestically. Methods We collected 365 articles on Bee venom study result from the OASIS systemusing the Keyword ‘bee venom, apitoxin, apitherapy, bee sting’. The initially selected theseswere primarily screened for clinical research. Out of these, case studies and nonrandomized controlled trial (non-RCT) were ruled out. As a result, 39 studies of randomizedcontrolled trial (RCT) research were chosen as the subjects of study. Results RCT research related to bee venom was first presented in 2003, and 39 studieshave been published until 2012. 18 studies were tests to confirm the effectiveness of beevenom, 7 studies were comparisons between SBV and BV, and 13 studies were comparisonswith other types of treatment. Research conducted through appropriate randomizationmethods were 20 studies, and inappropriate randomization methods were used in19 studies. In therms of Jadad score, 12 studies received 4~5 points, 15 studies received1~3 points, and 12 studies received zero point. Conclusions In order to assure good quality RCT research, appropriate guidelinesshould be provided, and proper evaluation standards should be established. In-depthstudy is needed concerning the difference of responses to treatment according to thetypes of treatment received. A standardization of treatment should be reached as a result.

Objectives The purpose of this study was to evaluate the most effective stimulatingelectrode in Microcurrent electrical neuromuscular stimulation (MENS) for pain relief, andto apply to the treatment of Delayed onset muscle soreness (DOMS). Methods We included 45 participants who met the inclusion criteria. DOMS of bothTriceps Surae Muscles were experimentally induced through eccentric contractions. 24-hours after induction of DOMS, who scored more than 40 mm in visual analogue scale(VAS) were randomly assigned into three groups (n=44). In 15 of them, needle electrodeswere inserted into BL57, BL56. In 15 of them, surface electrodes were applied on thesame points and the others were treated with manual acupuncture. The effects of pain reliefwere assessed by visual analogue scale (VAS), mechanical pain threshold (MPT), surfaceelectromyography (SEMG). Results In VAS, group comparison had no significant difference after all treatments haddone. The difference in VAS between the time before the treatment was started (Day 2)and after all treatments were completed was greater in Acupuncture group than that ofneedle-electrode group. In MPT, there was no significant difference among groups. Electrical contraction decreased significantly at 2nd before-after treatment comparison inneedle-electrode MENS group. But fatigue scores were not significantly different betweengroups. Conclusions The results suggest that the types of electrodes has no significant effecton microcurrent therapy in DOMS.

Objectives The aims of this study was to observe the effectiveness of East-WestIntegrative Medicine (EWIM) by analysing between EWIM estimated group and Non-EWIMeastimated group with Brain Rehabilitation Registry. Methods We divided hospitals into two groups, one is EWIM estimated group hospital(Kyeonghee university, Wonkwang university, Dongguk university) and the other isnon-EWIM estimated group (Jeonnam university, Gyeongbuk university, Catholic university). Then we analysed the effectiveness of treatments retrospectively using the databaseof Brain Rehabilitation Registry (http://www.kbrr.or.kr/, version 1.0). Totally 293 patientswere included, EWIM estimated group was 175 and non-EWIM estimated group was118. The main outcome measurements were National Institutes of Health Stroke Scale(NIHSS), Modified Barthel Index (MBI) and Mini Mental State Examination-Korea (MMSE-K). Results Changes of NIHSS was not significant in both total patient and patient whotreated over 3 weeks. MMSE-K showed positively significant difference (p=0.044) in EWIMestimated group patients who treated over 3 weeks. In case of MBI, EWIM estimatedgroup showed more effective result and also statistically significant in both total patientsand patients who treated over 3 weeks. Conclusions We patially argued that EWIM estimated group was more effective thannon-EWIM estimated group in stroke patients' functional recovery. We suggested basedata of EWIM in stroke patiens through this study and this could be applied future researchesof developing modified EWIM system.

Objectives The purpose of this study was to compare the effects of acupuncture treatmentwith those of collaborative treatment regarding acute Bell's palsy. Methods Twenty-six patients who received outpatient treatment between March 2012and February 2013 were divided into 2 groups. The East-West treatment group (EWgroup, n=12) received prednisolone and then acupuncture afterwards. The Eastern treatmentgroup (E group, n=14) received just acupuncture. Acupuncture was administered 3to 4 times a week, and both groups were educated to practice facial muscle exercises athome. Evaluations were made before treatment, after 1 week, 2 weeks, and 3 weeks usingthe House-Brackmann facial nerve grading system. Results Compared to before treatment, the House-Brackmann grades of both EW andE groups after 1, 2 and 3 weeks of treatment significantly decreased (p＜0.05). Regardinggroup comparison, the House-Brackmann grade of the EW group was significantly lowerthan the E group at 1 week (p=0.043), but there was no significant difference at 2 and 3weeks. Regarding improvement of House-Brackmann grades, there was no significant differencebetween the two groups at 1, 2 and 3 weeks (p＞0.05). Conclusions Compared to just acupuncture treatment, collaborative treatment withprednisolone significantly improved the House-Brackmann grade after 1 week, but therewas no difference as time passed. Because early intervention determines the prognosis ofBell's palsy, collaborative treatment at the early stage will be clinically helpful to patients.

Objectives The aim of this clinical study was to find out the changes of self-reportedpain intensity before and after balneothrapy in participants with low back pain. Methods In this study 20 participants with low back pain went through 5 weeks of balneothrapycourse, once in a week. Each week visual analogue scale (VAS) and painthreshold were measured before and after balneothrapy, which consisted of 30 minutes ofhigh pressure underwater shower (32~36oC) and another 30 minutes of whole body bathing(32~40oC). Results 1. The average of VAS significantly decreased from 64.00±16.35 to34.00±15.69 after 5 weeks of balneothreapy (p＜0.001). 2. The average of pain thresholdsignificantly increased from 8.31±2.52 lbf to 9.53±3.11 lbf after 5 weeks of balneothreapy(p＜0.05). Conclusions The results showed that 5 weeks of balneotherapy had significant effecton alleviating pain in low back pain participants, which means balneothreapy may be usedas a complementary treatment on musculoskeletal diseases and other chronic diseases. Further studies are anticipated in the future to find out other various effects of balneothrapy.

Objectives The purpose of this study was to investigate the clinical effects of repeatedlyperformed of balneotherapy on cervical pain. Methods We investigate 19 cervical pain subjects in this study. Subjects took 5 sessionof balneotherapy once a week during 5 weeks. Each session consisted of 15 minutes ofhigh pressure underwater shower (32~36oC) and another 15 minutes of whole body bathing(32~40oC). To evaluate the efficiency of balneotherapy visual analogue scale (VAS) andpain threshold were applied before treatment and after 1st, 2nd, 3rd, 4th, 5th treatment. Then the results were analysed. Results 1) The average of VAS significantly decressed from 59.11±14.67 to 33.95±20.988 after 5 weeks of balneothreapy treatment (p＜0.001). 2) The average of painthreshold significantly increased from 5.76±1.294 lbf to 8.74±1.126 lbf after 5 weeks ofbalneothreapy treatment (p＜0.001). Conclusions Balneotherapy has clinical effscts of pain reduction on cervical painsubjects. Balneotherapy can be used in addition to the Oriental physiotherapy for high effectivetreatment on cervical pain. Further clinical studies are required to verify thesefindings.

Objectives This study was designed to: (1) investigate the clinical feature of tongue diagnosis,(2) make an observation of significant changes in tongue diagnosis according tothe patient's physical condition and laboratory result and (3) identify clinical efficacy oftongue diagnosis. Methods 300 patients' tongue diagnosis results were analyzed and the patients weredivided to each group according to the physical condition and laboratory result. Then,chi-square test was performed to assess statistical significance between tongue diagnosisresults of each group. Results As a result of analyzing the spread of tongue diagnosis according to the patient'sphysical condition and laboratory result, 18 groups had statistical significance relatedto specific tongue color and tongue coating. Conclusions Even if there would be possible misinterpretations in one-to-one matchbetween the tongue diagnosis and certain diseases, we identified that tongue diagnosisresults were changed somewhat related to patient's physical condition with some tendencyand tongue diagnosis could be used for meaningful clinical diagnostic tool.

Objectives Herniated Intervertebral Disc of C-spine is one of the most common diseasesthat causes posterior neck pain. This study was designed to analyze the generaldistribution and hospital cost by day and case of Korean medical treatment for CervicalHerniated Intervertebral Disc (HIVD). Methods The 132 impatients for treatment of HIVD were analyzed according to the distributionof sex, age, the duration of HIVD, the contributory factors, the Clinical grade atadmission, the clinical findings at admission, the duration of hospitalization, the clinicalgrade at admission and the hospital cost per day and case. Results 1) The total hospital cost per case averaged 1,985,600 Won, which was consistedof room charge 584,044 Won (29.41%), performance fee 511,463 Won (25.76%),herbal medication 381,517 Won (19.21%), Korean medical physiotherapy 296,310 Won(14.92%), food expenses 199,997 Won (10.07%) in order. 2) The total hospital cost perday averaged 137,285 Won, which was consisted of room charge 39,036 Won (28.43%),performance fee 33,594 Won (24.47%), herbal medication 30,642 Won (22.32%), foodexpenses 12,870 Won (9.37%), and the average duration of hospitalization was 15.1days. 3) There was statistically significant difference in the consultation fee, room charge,and herbal medication on the part of sex. 4) There was statistically significant differencenot only in the performance and consultation on the part of duration of hospitalization butalso the in the duration of average duration of hospitalization. 5) There was statistically significantdifference in the Korean medical physiotherapy and herbal medication on the partof clinical findings. 6) There was statistically significant difference in the Korean medicalphysiotherapy and herbal medication on the part of duration of HIVD. 7) There was statisticallysignificant difference in the Korean medical physiotherapy and herbal medication onthe part of clinical outcome. 8) There was not only statistically significant difference in theperformance, but also in the herbal medication on the part of clinical grade at admission. Conclusions This study provides plenty of information to design out the specific termsof Korean medical expenses of Cervical HIVD inpatients hospitalized at Korean medicinehospital.

Objectives This study is to evaluate the current situation of Russian tourists for medicaltourism of Spine Specialty Korean Medicine Hospital. Methods 133 Russian tourists visiting Spine Specialty Korean Medicine Hospital fromJanuary 1, 2012 to December 31, 2012, were analysed in the statistics. Their data wassourced from the computerized medical records. And 87 of them answer a questionnaireabout reasons for selection of Spine Specialty Korean Medicine Hospital and satisfactoryfor medical service. Results A total of 133 Russian visited Spine Specialty Korean Medicine Hospital formedical service, consisting of 73 females (54.8%), the fourties to fifties 58.9% by age. They avoided visiting in the winter. The average number of visiting was 7.1 times. Theaverage treatment period was 9.9days. Majority of the elapsed time from the onset to thearrival was more than 1 year (56.6%). Low back pain (56.4%) is the most in musculoskeletaldisorders and obesity (21.7%) and gynecological diseases (30.4%) were themost in a non-musculoskeletal disorders. Medication and acupuncture was the majortreatment. 89.2% of the prescribed medication was the efficacy of musculoskeletal. Russian medical tourists most visited by support of travel agent (58.6%). The main reasonof their visiting was non-surgical treatment for spinal disorder (31%). 96.6% of them weresatisfied because rapid pain relief and kindness. Conclusions For this study, we confirmed a possibility for the Korean medical treatmentof Russian tourists for medical tourism. Still, more research and goverment support for theexpansion of Korean medical tourism is needed.

Objectives The purpose of this study was to measure the expectation of patients visitingthe Korean medical hospital for treatment from traffic accident (TA). Methods The data were collected with a questionnaire for about 1 year. The subjectswere 39 patients who hospitalized in Korean Medical Hospital after TA. All data were analyzedusing SPSS (Statistical Package for the Social Science) program to analyze. Results Acupuncture (8.36) had the highest expectation degree which was followed byHerbalmedicine (8.32), Pharmocoacupuncture (8.14). There were no significant differencesin the expectation degree with sex, age, education, occupation. The patients whohad experienced Korean medicine treatment had high expectation degree in Pharmocoacupunctureand Herbalmedicine. And the expectation was different significantly (p＜0.05). Conclusions The expectation of TA patients was high in Acupucture and Herbalmedicine. The group experienced korean medical treatment before had high degree of expectationin Palmacoacupuncture and Herbalmedicine.

The purpose of this study is to evaluate the effect of active release technique on sequelae of tibial plateau fracture. Two patients with sequelae of tibial plateau fracture were treated with active release technique. Visual analog scale (VAS), Lysholm knee scoring scale, range of motion were used to measure changes during treatment. After treatment, visual analog scale, Lysholm knee scoring scale, range of motion were improved significantly. Active release technique showed significant improvement to the sequlae of tibial plateau fracture that were showing no signs of improvement for twelve and eighteen weeks. This clinical trial showed that active release technique has meaningful effect on sequlae of tibial plateau fracture and more research should be followed.

The purpose of this study is to report the effect of oriental medical treatments with exercise therapy on the frail elderly patient with gait disturbance and cognitive decline. The frail elderly patient with gait disturbance and cognitive decline was treated by oriental medical treatments combined with exercise therapy during 3 months. The improvement of clinical symptom was evaluated by Manual Muscle Test (MMT), Passive Range Of Motion (PROM), Mini Mental State Examination-Korea (MMSE-K). After 3 months, all of both lower extremity Manual Muscle Test (MMT) improved to Grade 4. Both knee extension Passive Range Of Motion (PROM) and Mini Mental State Examination-Korea (MMSE-K) also increased from -30/-30 to 0/-5, from 7 to 25 respectively. It could be suggested that oriental medical treatments with exercise therapy were effective on the frail elderly patient with gait disturbance and cognitive decline. And further research is encouraged to confirm the effectiveness of this treatment with a larger number of patients.