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2016, Vol.26, No.3

  • 1.

    Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats

    Jong-Hoon Lee | Chang-Hoon Woo | Young Jun Kim and 1other persons | 2016, 26(3) | pp.1~15 | number of Cited : 4
    Abstract
    Objectives: This study was designed to evaluate the anti-inflammatory effects of Seungseup-tang (SST) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods: Osteoarthritis was induced by injection of MIA (50 μl with 80 mg/ml) into knee joint cavity of rats. Rats were divided into 4 groups (normal group, control group, in-domethacin treated group, SST treated group, each n=6). Normal group was not injected with MIA and taken normal diet. Control group was injected with MIA and taken with dis-tilled water. Indomethacin treated group was injected with MIA and taken indomethacin 5 mg/kg by oral administration. SST treated group was injected with MIA and taken SST 200 mg/kg by oral administration. We examined the weight-bearing ability of hind paw, bio-markers related to oxidative stress in serum, inflammatory proteins and inflammatory medi-ators and cytokines. Moreover, histopathological examination of knee joint structure was also performed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results: In the present study, SST treated group showed a similar inhibitory effects alike indomethacin treated group, in most of the studied parameters of inflammation. The in-creased oxidative stress biomarker such as reactive oxygen species (ROS) and peroxy ni-trite (ONOO−) in the serum were reduced with SST. Especially, the level of ONOO− com-pared with control group significantly suppressed. Also, the expression of inflammatory mediators and cytokines induced by nuclear factor-kappa B (NF-κB) activation was modulated through inhibition of IkBaphosphorlation. In addition, histological analysis re-vealed that cartilage damage by MIA repaired markedly in SST treated group.Conclusions: According to the results, Seungseup-tang may be effective for preventing the progression of osteoarthritis. (J Korean Med Rehabil 2016;26(3):1-15)
  • 2.

    Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model

    원정윤 | Ji-Won Jeong | Changsu Na and 1other persons | 2016, 26(3) | pp.17~30 | number of Cited : 4
    Abstract
    ObjectivesThe purpose of this study was to find out the effects of ChondroT on arthral-gia of the Collagenase-induced osteoarthritis in rats.MethodsOsteoarthritis was induced into rat by injecting Collagenase in its knee joint. Rats are divided into a total of 8 groups (n=6). Normal group was not induced for osteo-arthritis whereas control groups were induced for osteoarthritis by Collagenase. Positive-A (Indomethacin) was injected with Collagenase and after 8 days, 2 mg/kg of Indomethacin was medicated. Positive-B (JOINS TAB) was injected with Collagenase and after 8 days, 20 mg/kg of JOINS TAB was medicated. Experimental groups (Chondro T) at three dose levels (50, 100 and 200 mg/kg) were injected with Collagenase and after 8days they were medi-cated with 10 ml/kg. Indomethacin, JOINS TAB and ChondroT were medicated each sub-stances once a day for 10 days. Thereafter, the changes in plantar withdrawal response of osteoarthritis rats by dynamic plantar aesthesiometer were observed and then RT-PCR analysis was done to investigate the expression of related proteins.Results1. ChondroT significantly decreased withdrawal response of mechanical allody-nia compared with control group in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 2. ChondroT significantly reduced Bax/Bcl-2 ratio in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 3. ChondroT significantly reduced the expression of INF-γ compared with control group in group ChondroT-B, ChondroT-C.ConclusionsThis results suggest that ChondroT may be meaningful for suppressing the pain of osteoarthritis. Further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2016;26(3):17-30)
  • 3.

    Effects of Joaguihwan (JGH, 左歸丸) Extract on Changes of Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and on Factors Related with Bone Metabolism in Skull Fractured Rat

    Yu-Chen Li | Minseok Oh | 2016, 26(3) | pp.31~49 | number of Cited : 3
    Abstract
    ObjectivesThe study was designed to evaluate the healing effects of Joaguihwan (JGH) extract on Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and factors related with bone metabolism in skull fractured Rat.MethodsThe fracture healing effect of JGH was measured by scavenging activities of1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and nitric oxide (NO) in RAW 264.7 cells. The inhibitory effect against the pro-duction of inflammatory mediators including interleukin-1β (IL-1β), interleukin-6 (IL-6), tu-mor necosis factors-α (TNF-α) expression was inhibited in RAW 264.7 cells was ex-perimented using JGH. The effects of JGH on healing fractured rats was measured by os-teocalcin, calcitonin, CTXII, TGF-β, BMP-2, Insulin, ALP in the serum. and was checked every 3 weeks from 0 week to 6week using x-ray.Results1. DPPH free radica and ABTS scavenging activity of JGH were increased ac-cording to concentration of JGH in RAW 264.7 Cells. 2. In the experiment, NO, IL-1β, IL-6, TNF-α all showed decrease, in general. Especially NO and IL-1β showed significantly de-crease at a concentration of 10, 100 (μg/ml). 3. In the production of osteocalcin in the se-rum, JGH 200, 400 mg/kg experimental group showed significant increased effect at 2 weeks. 4. In the production of calcitonin in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. 5. In the production of CTX, TGF-β, BMP-2 in the serum, experimental group showed increased effect. but no significant effect. 6. In the production of insulin in the serum. JGH 200, 400 mg/kg experimental group showed significant decrease effect at 2, 4, 6 weeks. 7. In the production of ALP in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 4, 6 weeks. 8. In the change of X-ray, the experimental group showed better healing effects on skull fractured rats than control group.ConclusionsFrom above results, JGH showed healing effect on Anti-oxidation, Anti-in-flammatory in RAW 264.7 Cells, factors related with bone metabolism in the serum of skull fractured rat and x-ray, which is expected to be applied in clinics. (J Korean Med Rehabil 2016;26(3):31-49)
  • 4.

    Anti-Oxidative and Anti-Inflammatory Effects of Cheongajihwang-Tang Extract on RAW264.7 Cells

    윤정원 | 김순중 | 박동수 | 2016, 26(3) | pp.51~58 | number of Cited : 1
    Abstract
    ObjectivesThis study was designed to investigate whether the Cheongajihwang-Tang (CT) has an inhibitory effect association with oxidation or inflammation in RAW264.7 cells.MethodsCytotoxic activity of CT extract on RAW264.7 cells was evaluated by using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) solution. Nitric oxide production was measured using Griess reagent system. The total phenolic contents and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was measured to evaluate the anti-oxidative effects of CT. Dichlorofluorescin diacetate (DCFH-DA) has been used as a substrate for measuring intracellular oxidant production.ResultsCheongajihwang-Tang does not impair the cell viability in tested concentration. CT showed anti-oxidative effects in vitro by decreasing electron donating ability, and also showed anti-inflammatory effects suppressing NO and ROS expression in LPS induced RAW264.7 activation. CT inhibited the generation of intracellular ROS production as dose dependant manner.ConclusionsCT has anti-oxidative effects and anti-inflammatory activities. These results indicate that CT extract has an anti-inflammatory activities via anti-oxidative effects. (J Korean Med Rehabil 2016;26(3):51-58)
  • 5.

    Domestic Research Trend of the Ossicification of the Posterior Longitudinal Ligament in Korean Medicine

    안민윤 | Lim Hyung Ho | 2016, 26(3) | pp.59~65 | number of Cited : 1
    Abstract
    ObjectivesThe purpose of this review is to analyze domestic research trend of the ossifi-cation of posterior longitudinal ligament in Korean medicine.MethodsWe searched articles in Korean databases such as OASIS, RISS, NDSL and sorted the articles by journals, published year, institutions and research type.Results9 suitable theses were reviewed. They were published between 2002 till 2011. Most of the theses were published in The Acupuncture, the journal of Korean Acupuncture & Moxibustion Medicine Society. There were 6 case reports, 2 case series and single dis-ease review.ConclusionsThere were only 9 studies about the ossification of posterior longitudinal lig-ament in Korean medicine and most of them were case reports. To reinforce the evidence of effectiveness of Korean medicine, additional studies are required and well designed studies such as randomized controlled trials need to be carried out. (J Korean Med Rehabil 2016;26(3):59-65)
  • 6.

    Systematic Review of Bee Venom Therapy for Traumatic Injury

    이재은 | 이치호 | Eun-Jung Lee and 2other persons | 2016, 26(3) | pp.67~77 | number of Cited : 3
    Abstract
    ObjectivesTo evaluate the evidence supporting the effectiveness of Bee Venom therapy for traumatic injury.MethodsWe conducted search across 3 electronic databases (Pubmed, CAJ and Oasis) to find clinical trials that used Bee Venom therapy as treatment for traumatic injury. The methodological quality of RCTs (Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clin-ical trials) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool.ResultsAmong 87 articles that were searched, 10 RCTs and 19 NRCTs were finally selected. Among 19 selected studies, all studies showed that Bee Venom therapy has sig-nificant effect on traumatic injury.ConclusionsOur systematic review found encouraging but limited evidence of Bee Venom therapy for traumatic injury. We recommend clinical trials which compare the effec-tiveness of Bee Venom therapy with other pharmacopuncture therapies to clarify the effec-tiveness of Bee Venom therapy from other pharmacopuncture therapies. (J Korean Med Rehabil 2016;26(3):67-77)
  • 7.

    Chuna Manual Therapy for Primary Insomnia; A Review of Clinical Study

    황만석 | 2016, 26(3) | pp.79~84 | number of Cited : 2
    Abstract
    ObjectivesTo evaluate the evidence supporting the effectiveness of Chuna manual ther-apy for primary insomnia.MethodsThe researcher conducted search across the 3 electronic databases (Pubmed, CAJ and Oasis) to find all of randomized controlled clinical trials(RCTs) that used Chuna manual therapy as a treatment for primary insomnia.ResultsFour RCTs met inclusion criteria. The meta-analysis showed positive results for the use of Chuna manual therapy in terms of the PSQI when compared to medication treat-ments alone. Positive results were also obtained, in terms of the PSQI, when comparing Chuna manual therapy combined with acupuncture therapy to acupuncture therapy alone, but was not statistically significant.ConclusionsThe review found encouraging but limited evidence of Chuna manual ther-apy for primary insomnia. We recommend clinical trials which compare the effectiveness of Chuna manual therapy with usual care to obtain stronger evidence without the demerits of trial design. (J Korean Med Rehabil 2016;26(3):79-84)
  • 8.

    A Study on Research for Utilization Acupuncture Treatment in Military Medicine

    최희승 | Yun-Yeop Cha | 2016, 26(3) | pp.85~95 | number of Cited : 1
    Abstract
    ObjectivesMilitary medicine is the study of research which includes health, sanitation, clinic, and quarantine in military personnel. This study is focused on research the acu-puncture treatment of military medicine.MethodsThe study on acupuncture research for Military Medicine was referred from via KoreaMed, OASIS, The Journal of Korean Military Medical Association, KMbase, KAMJE, NDSL, KISS, KISTI, PubMed, MEDLINE, EMBASE, and The Cochran library. As a result, 18 research papers were found and they were analyzed according to the year of publishment, the titles of journals, the nation of research center, the types of study, the purpose of study, the outcome of measurement, the type of acupuncture, and the assessment of acu-puncture effect. And then assessed the risk of bias about RCT, NRCT, prospective cohort studies, and before and after studies.ResultsThe number of the published research papers on acupuncture was increased since 2013. The studies were mainly published in the USA and eight out of 18 were RCT. The purpose of study is mostly for musculoskeletal and psychological disease and medical decision for acupuncture. The type of the acupuncture used is not only traditional acu-puncture but also the auricular acupuncture. Even though the research results about the ef-fect of acupuncture were excellent and positive, some of studies had a high risk of bias.ConclusionsThe studies state about acupuncture treatment as mostly positive and ef-fective, however, further clinical studies are required to obtain objective clinical evidence of acupuncture treatment. Furthermore, future trials would be needed to find out effective acupuncture treatments on military duty. (J Korean Med Rehabil 2016;26(3):85-95)
  • 9.

    Effectiveness of Korean Medicine Treatment on Lumbar Intervertebral Disc Herniation Patients’ Fear-Avoidance Belief

    최영준 | 문병헌 | 주영국 and 5other persons | 2016, 26(3) | pp.97~108 | number of Cited : 0
    Abstract
    ObjectivesThis study is planned to classify effectiveness of Korean medicine treatment on lumbar intervertebral Disc herniation patients' fear-avoidance belief.MethodsWe measured 84 patients with lumbar intervertebral disc herniation in Jaseng Korean Medicine Hospital. We used numeric rating scale, oswestry disability index, fear-avoidance belief questionaire for evaluating effectiveness of oriental medicine treat-ment on lumbar intervertebral disc herniation. And We used Magentic Resonance Imaging (MRI) for classifying the patient who has lumbar intervertebral disc or not.Results1. There was statistical effectiveness of korean medicine treatment on lumbar in-tervertebral disc herniation patients' fear-avoidance belief (p<0.01). ΔNRS and ΔODI (r=0.587) was Most statistically correlative. ΔODI and ΔFABQ had a little of statistically correlation (r=0.313). ΔNRS and ΔFABQ has no statistically correlation (r=0.145).ConclusionsThis study suggests that screening for the korean medicine treatment re-duces fears and negative belief of patients with the lumbar disc herniation and prevents chronic physical symptoms that come from them so that it can be a great help to control-ling patients' pain clinically. (J Korean Med Rehabil 2016;26(3):97-108)
  • 10.

    The Correlation between Cross-sectional Area of Lumbar Paraspinal Muscles and Walking Ability in the Patients with Lumbar Spinal Stenosis

    김민철 | 서영훈 | 이상민 and 7other persons | 2016, 26(3) | pp.109~117 | number of Cited : 1
    Abstract
    ObjectivesThe purpose of this study was to investigate the correlation between walking ability of lumbar spinal stenosis patients and the cross-sectional area (CSA) of lumbar para-spinal muscles.MethodsThis study was carried out on 62 lumbar spinal stenosis patients who had lim-ited walking abilities because of neurogenic claudication (NC). All patients received more than 2 weeks of complex treatment at Mokhuri Neck&Back Hospital. CSA of lumbar para-spinal muscles was measured from axial T2-weighted MRI and divided by CSA of adjacent vertebral body to avoid influence of body statues (RCSA-Relative CSA). Pain Free Walking Distance and Numerical Rating Scale (NRS) was measured before and after treatment.ResultsThe Pain Free Walking Distance had significantly increased in patients who had bigger RCSA of psoas muscle (r=0.313, p<0.05).ConclusionsThe psoas muscle can be a predictive factor for restoring walking ability of lumbar spinal stenosis patients who have limitations walking. (J Korean Med Rehabil 2016;26(3):109-117)
  • 11.

    Effect of E10 on Relief of Cervical Myalgia; One Group Pre-Post, Pilot Trial Study

    정동훈 | 김혜정 | 김정섭 and 3other persons | 2016, 26(3) | pp.119~128 | number of Cited : 0
    Abstract
    ObjectivesThe purpose of this study is to investigate the efficacy of E10 on the relief of cervical myalgia.MethodsThis study is a one group pre-post, pilot trial test. After the approval of institu-tional review board (IRB), we have recruited 25 patients suffering from cervical myalgia. 23 patients (2 patients dropped out) was treated by using E10 on the cervical muscle and acu-puncture points, three times a week for a total of two weeks from February 2016 to April 2016. Evaluations of VAS for bothersomeness of neck pain (VASB), VAS for pain intensity (VASP), NDI, SF-36, X-ray, thermography, etc. before and 1 week after treatment were car-ried out. The primary outcome measure was the VASB, measured 1 week after the end of the therapy.ResultsVASB scores was significantly decreased from 72.5±9.9 to 50.4±9.9. VASP scores was significantly decreased from 71.5±10.5 to 48.5±18.3. Results showed sig-nificant improvements in VASB, VASP, NDI, SF-36 from the baseline. However, in X-ray, thermography, there was no singnificant difference.ConclusionsThis study demonstrates the effectiveness of E10 treatment for relieving cervical myalgia. (J Korean Med Rehabil 2016;26(3):119-128)
  • 12.

    Selection of Manageable Diseases for Quality Assessment in Korean Medicine by Delphi Method

    박창현 | Lim Hyung Ho | 2016, 26(3) | pp.129~141 | number of Cited : 0
    Abstract
    ObjectivesAs awareness of the public about Korean medicine health care and the social demand about improvement for quality of health care service is constantly rising, the quality evaluation of Korean medicine health care service is needed to improve the quality. Through trial of Delphi method, we tried to set the priority in short, medium, long term among the disease which is the subject of quality assessment.MethodsCarrying out the delphi survey to 50 experts of korean medicine who were rec-ommended by the 41 member societies of Korean medicine and related organizations, we selected final candidates for quality assessment. It is composed with total 2 rounds, and we investigated the priority in three aspects; the importance of the matter, possibility quality assessment, potential about if there's any chance of improvement.ResultsBy delphi method, we set the priority of quality assessment. Base on the result of the second round, we classified importance of the questions into above average, average, below average, and categorized items as short, medium, long term according on the final priority. We classified of musculoskeletal diseases and diseases of connective tissues and musculoskeletal injury as short term and cerebrovascular disease and disease of nerve sys-tem and malignant neoplasm as medium term, disease of digestive organs and diseases, symptoms and abnormal findings in clinical field or inspections which are not categorized as long term.ConclusionsWe set the subjects of quality assessment by delphi survey by experts, and classified into short, medium, long term. Further research is necessary for execution the Quality Assessment to each of the candidate. Also, we can send feedback to medical in-stitution base on the result of Quality Assessment. then it would be able to induce the im-provement in quality of medical institution by itself. (J Korean Med Rehabil 2016;26(3): 129-141)
  • 13.

    A Case Report of Complex Korean Medical Treatment for Cervical Spinal Cord Injury and Neurogenic Bladder

    송민영 | Hee-Geun Jo | 김태광 and 1other persons | 2016, 26(3) | pp.143~151 | number of Cited : 3
    Abstract
    A 57-year-old male patient was diagnosed as Incomplete cervical spinal cord injury and Neurogenic bladder after falling accident and suffered from tetraplegia and urinary retention. The patient was hospitalized and treated with Complex Korean Medical treatment such as acupuncture, electro-acupuncture, bee venom pharmacopuncture and herbal medication for 13 weeks. International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) was adopted to evaluate the functional recovery and Korean version of Modified Barthel Index (K-MBI) was adopted to evaluate the recovery of activities of daily living (ADL). After treatment, Total scores of ISNCSCI and K-MBI were improved. Also patient's mictur-ition reflex was recovered and symptoms of neurogenic bladder were improved. This result shows that Korean Medical treatment may be an effective treatment option for spinal cord injury and neurogenic bladder patients. Further clinical studies are needed to clarify the ef-fect of Korean Medical treatment on spinal cord injury. (J Korean Med Rehabil 2016;26(3):143-151)
  • 14.

    A Rehabilitation for Total Hip Replacement in Korean Medicine: A Report of Three Cases

    하원배 | 이종하 | Youn-Seok Ko and 1other persons | 2016, 26(3) | pp.153~164 | number of Cited : 11
    Abstract
    The objective of this study was to propose a rehabilitation protocol for total hip replacement in Korean medicine and to report its effectiveness. Three patients who had undergone total hip replacement were treated using the rehabilitation protocol in Korean medicine. We eval-uated the outcome evaluating physical examination findings of the hip joint, numeric rating scale, pain disability index, Harris hip score, and walking state. After the treatment, we ob-served that hip movement and muscular strength improved. Moreover numeric rating scale, pain disability index, Harris hip score, and walking state of patients improved. A re-habilitation in Korean medicine can be effectively used for total hip replacement patients. The limitation of this study was the insufficient number of cases. Further studies are needed to design a rehabilitation protocol in Korean medicine. (J Korean Med Rehabil 2016;26(3):153-164)
  • 15.

    The Clinical Reaction Study on 64 Cases with Essential Bee Venom Treatment

    전용태 | 고 웅 | 김성문 and 4other persons | 2016, 26(3) | pp.165~170 | number of Cited : 0
    Abstract
    ObjectivesThe purpose of this study was to observe clinical reactions (itching, pain, etc.) after Essential Bee Venom (EBV) treatment.MethodsThis study was conducted 64 patients who had been injected with EBV in Korean Medicine Hospital of Woosuk University and Haeundae Ja-Seng Hospital of Korean Medicine from October 5, 2015 to February 20, 2016. We checked clinical reactions of treatment region.Results8 patients (12.5%) complained of localized itching and 4 patients (6.3%) com-plained of localized pain after EBV injection. In itching reaction of patients, 2 patients (15.4%) occurred itching in head and neck, 4 patients (12.9%) occurred in lumbar and back. In pain reaction of patients, 2 patients (6.5%) occurred pain in lumbar and back, 1 patient (11.1%) occurred pain in upper limb. All clinical reactions were happened within 7 treatment times. ConclusionsThis study suggested EBV treatment can cause clinical reaction like itching and pain. Clinical reactions were more common in inpatients than outpatient, and all re-actions were happened within 7 treatment times. Doctors should recognize physical re-action caused by EBV and explain to patient. Further studies are needed to more improved treatment. (J Korean Med Rehabil 2016;26(3):165-170)
  • 16.

    The Case Report of Chronic Ankle Sprain Improved with Hominis Placenta Pharmacopuncture Treatment

    이동은 | 박원형 | 차윤엽 | 2016, 26(3) | pp.171~181 | number of Cited : 3
    Abstract
    ObjectivesThe purpose of this study is to investigate and report the effectiveness of Hominis Placenta pharmacopuncture treatment for chronic ankle sprain.Methods2 patients are treated at Dept. of Korean Medicine, the Armed Forces Busan Hospital, diagnosed as thinning of anterior talofibular ligament (ATFL), suggestive of partial tear and anterior tibiofibular ligament partial tear. They are treated with Hominis Placenta pharmacopuncture. Each cases are measured and assessed by ankle hindfoot scale (AHS), visual analgue scale (VAS), cumberland ankle instability tool (CAIT) scores.Results2 patients of chronic disease of ankle sprain have a different kind of diagnoses they have. After treatment of Hominis placenta pharmacopuncture, spontaneous pain is decreased and ankle instability, ankle functions are increased significantly.ConclusionsHominis placenta Pharmacopuncture has a effect on chronic ankle sprain. (J Korean Med Rehabil 2016;26(3):171-181)
  • 17.

    A Case of Therapeutic Laser for Suggested Drug Induced Liver Injury Patient during Treatment of Korean Medicine

    Lim KyeongTae | Shin, Byung Cheul | Hwang Eui-hyoung and 3other persons | 2016, 26(3) | pp.183~189 | number of Cited : 1
    Abstract
    A 84 year old male patient with amyotrophic lateral sclerosis (ALS) was treated by Jeungsonbaekchulsan and Gakbyeongyeonsu-tang for ten days. In the course of treat-ments, this patient was evaluated with Roussel Uclaf Casusality Assessment Method (RUCAM), showing results of drug induced liver injury. Herb medicine was immediately dis-continued, followed by therapeutic laser treatments once a day for one week combined with 2 weeks of GODEXⓇ administration. Transaminase results were lowered and changes in blood test results were time-effective changes. Therapeutic laser therapy could be con-sidered effective on drug induced liver injury with further studies. (J Korean Med Rehabil 2016;26(3):183-189)