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2017, Vol.27, No.2

  • 1.

    The Protective Effects of Pueraria Radix against Chronic Alcohol-induced Muscle Atrophy in Rats

    김범회 | 2017, 27(2) | pp.1~8 | number of Cited : 1
    ObjectivesEthanol is a potent inhibitor of muscle protein synthesis. Muscle mass is regulated by the balance between rates of protein synthesis and protein breakdown. Both acute and chronic alcohol consumption inhibits synthesis to a greater extent than degradation. Protein synthesis is more intensely decreased in type II fibers than in type I fibers. Apoptosis has been shown to occur frequently in a variety of tissues in response to chronic alcohol feeding. Increased muscle fiber apoptosis has been shown in alcoholics with myopathy. Pueraria radix has been used for many disorders such as fevers, gastro-intestinal disorders, muscle aches, allergies, respiratory problems, skin problems, high blood pressure, migraine headaches, lowering cholesterol and treating chronic alcoholism. We therefore tested the hypothesis that oral treatment with Pueraria radix could reduce the ethanol-induced muscle atrophy. MethodsYoung male Sprague-Dawley rats were orally given 25% ethanol (5 ml/kg, body weight) daily with Ethanol for 4 weeks. Normal group was similarly administrated with saline. The Rats of Pueraria radix treated group (EtOH+PR) were orally administrated Pueraria radix water extract, and rats of EtOH group were given with the vehicle only. After 4 week, the morphology of gastrocnemius and plantaris muscles were assessed by hema-toxylin and eosin staining. The immunoreactivities of pre-apoptotic BAX and anti-apoptotic Bcl-2 proteins were also measured.ResultsThe muscles from rats of EtOH group represented a significant reduction in aver-age cross section area compared to Normal group. EtOH+PR group had increased fiber compared to the EtOH group. Moreover, to investigate the ethanol-induced muscular apoptosis, the immunohistochemical analysis of Bax and Bcl-2 was carried out. The treat-ment with Pueraria radix (EtOH+PR) significantly decreased BAX expression and increased Bcl-2 expression 4 weeks after ethanol administration when compared with Normal group. ConclusionsThese results suggest that Pueraria radix water extract has protective ef-fects on chronic alcohol induced myopathy. (J Korean Med Rehabil 2017;27(2):1-8)
  • 2.

    Inhibitory Effects of Daeyeoungjeon on the Injury of Articular Cartilage Induced by Monosodium Iodoacetate in Rats

    서일복 | 정수현 | 박동수 | 2017, 27(2) | pp.9~17 | number of Cited : 2
    ObjectivesThis study was aimed to evaluate the effects of Daeyoungjeon (hereinafter re-ferred to DYJ) treatment on the injury of articular cartilage induced by monosodium iodoa-cetate in rats.MethodsTwenty-four male rats were divided into normal, osteoarthritic control and DYJ group. Rats of normal group were injected with 0.1 ml physiological saline, rats of control and DYJ groups were injected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Rats of DYJ group were administrated extracts of DYJ during 60 days per orally. At 60 days after treatment, gross lesions, area and proteoglycan con-tents of articular cartilage, histopathological lesions, immunohistochemistry on matrix met-alloproteinases (MMP-2, MMP-3, MMP-7) were evaluated.ResultsGrossly, degenerative changes of articular cartilages were observed weak in DYJ group. The areas of articular cartilages were broader significantly in DYJ group. The proteoglycan contents in articular cartilages were lesser significantly in DYJ group. Histopathologically, the chondrocyte score was lesser significantly in DYJ group. MMP-3 expression in articular cartilages was observed weak in DYJ group.ConclusionsFrom above results, DYJ treatment has inhibitory effects on the injuries of articular cartilage induced by monosodium iodoacetate in rats, and it's effects may be re-lated with down regulation of MMP-3. (J Korean Med Rehabil 2017;27(2):9-17)
  • 3.

    Effects of Bia-hwan (Féiér-wán) on the Ovariectomized Rat Model of Osteoporosis

    조창영 | Kim Eun-young | 김동희 and 5other persons | 2017, 27(2) | pp.19~27 | number of Cited : 2
    ObjectivesOsteoporosis is a common disease in adults with prevalence rate of more than 40%, and occurs more to female than to male. The purpose of this study is to identify the effect of Bia-hwan (Féiér-wán) on the osteoporosis of ovariectomized rats.Methods24 female rats were randomly assigned to a SHAM group, a control group, and a BAH group. Ovaries of the control group and the BAH group were extracted. After than, general animal feed were given to the SHAM group and the control group, animal feed con-tained BAH were given to the BAH group through mouths of them. After 8 weeks, rats were sacrificed and their weight, calcium, phosphorus, estradiol, total-cholesterol, triglyceride, ALP, albumin, AST, ALT, the weight of femur and tibia ash per body ratio, both area and thickness of trabecular bone, the area of osteoblast and the number of osteoclast were measured.ResultsThe level of calcium, phosphorus, AST in the serum of the BAH group increased significantly compared to the control group. There was no significant difference between the control group and the BAH group in the level of estradiol, total-cholesterol, triglyceride, ALP, albumin, and ALT in the serum. There was no significant difference between the con-trol group and the BAH group in the weight of femur and tibia ash per body ratio. The thick-ness of trabecular of the BAH group increased significantly compared to the control group, but there was no significant difference in the trabecular area. The area of osteoblast and the number of osteoclast of the BAH group decreased significantly compared to the control group.ConclusionsFrom the results of the above study, oral intake of BAH can inhibit the de-crease of calcium, phosphorus in blood and prevent the thinning process of the trabecular by suppressing activation of osteoclast. Thus, BAH may have effects on the treatment and prevention of osteoporosis. (J Korean Med Rehabil 2017;27(2):19-27)
  • 4.

    Salt-water Processing-dependent Change in Anti-oxidative and Anti-inflammatory Effects of Cortex Eucommiae

    고원일 | 이진호 | In-Hyuk Ha and 8other persons | 2017, 27(2) | pp.29~38 | number of Cited : 1
    ObjectivesThe present study aimed to investigate the change in marker compounds, anti-oxidative and anti-inflammatory effects of salt-water processed Cortex Eucommiae.MethodsTo evaluate the influence of processing on anti-oxidant effect of Cortex Eucommiae, changes in total phenol, total flavonoid, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging, and ferric reducing antioxidant power (FRAP) between processed and raw Cortex Eucommiae were assessed. In addition, nitrite assay was conducted to de-termine the influence of processing on anti-inflammatory effect of Cortex Eucommiae. Cell viability was also examined as to elucidate whether processing affects cytotoxicity of Cortex Eucommiae. Finally, high-performance liquid chromatography (HPLC) analysis was conducted to monitor changes in pinoresinol diglucoside amount of processed and raw Cortex Eucommiae.ResultsSalt-water processed Cortex Eucommiae showed higher total phenol and fla-vonoid amount, compared to raw Cortex Eucommiae. Furthermore, anti-oxidative activity of processed Cortex Eucommiae was improved as discovered in DPPH, ABTS, and FRAP assays. Anti-inflammatory effect of Cortex Eucommiae was also enhanced following salt-water processing, as evidenced in nitrite assay. HPLC analysis found that the amount of pinoresinol diglucoside, widely known as the marker compound of Cortex Eucommiae, increases through salt-water processing. All experiments were performed with non-toxic concentration of Cortex Eucommiae; processing did not affect the cytotoxicity of Cortex Eucommiae up to the currently adopted concentration.ConclusionsThe present results support that salt-water processing of Cortex Eucommiae is beneficial in terms of marker compound amount, anti-oxidative, and anti-in-flammatory activities. Additional investigations are needed to standardize the processing method of Cortex Eucommiae. (J Korean Med Rehabil 2017;27(2):29-38)
  • 5.

    The State of Clinical Trials on Acupotomy for Lumbar Disc Herniation in China

    Purumea Jun | Yan Liu | Ji-Eun Park and 2other persons | 2017, 27(2) | pp.39~54 | number of Cited : 3
    ObjectivesThis study aimed to search the Chinese literature on acupotomy for lumbar disc herniation and to analyze their methodologies.MethodsUsing 4 Chinese databases (CBM [www.sinomed.ac.cn], CNKI [www.cnki.net], WANFANG [www.wanfangdata.com], and WEIPU [www.cqvip.com]), we searched for clin-ical trials conducted in China over the past 10 years on acupotomy for lumbar disc herniation. The search terms used were “(腰椎椎間板脫出症 or 椎間板脫出症 or 椎間板脫出) and (针刀or 针刀松解术)” and we selected only meta-analyses that were published before December 2016. From among these meta-analyses, we excluded duplicates and selected the remaining 36 randomized controlled trials (RCTs) for our final analysis.ResultsThe largest numbers of acupotomy papers were published in 2008 and 2013 (8 papers each). The average number of subjects was 120; the most common treatment method used for the control group was standard acupuncture (in 11 papers), and the most common concurrent treatment in the treatment group was massage (in 10 papers). The most common site of needle insertion was between the spinous processes, or at less than 0.5 cm on either side of the spinous processes (in 24 papers). The most common site of adhesion lysis was at the transverse process (in 24 papers). Two studies were blinded, and the mean Jadad score was 1.17.ConclusionsA large number of RCTs on the use of acupotomy for lumbar disc hernia-tion are conducted every year in China, and the procedure has been shown to be very ef-fective, with few adverse effects. However, the average quality of the studies was not very high. Based on our study, we expect several high-quality clinical trials on acupotomy to be conducted in Korea in the future. (J Korean Med Rehabil 2017;27(2):39-54)
  • 6.

    Literature Review of Korean Medicine Studies for Fibromyalgia Syndrome (FMS)

    이정민 | 2017, 27(2) | pp.55~66 | number of Cited : 5
    ObjectivesThis study aimed to review studies in Korean medicine for fibromyalgia syn-drome (FMS).MethodsWe conducted search across 3 electronic databases (Korean traditional knowl-edge portal, RISS, Oasis) to find studies for FMS in Korean medicine. Studies of Korean medicine for FMS were included and analysed. Results15 studies were included. 2 studies were reviews and 13 studies were case reports. Total numbers of patients in case studies were 15. In case studies, acupuncture (100%), herbal medicine (76.9%), Korean physical therapy (69.2%), pharmacopuncture (53.8%), Chuna (46.1%) and moxibustion (30.7%) etc. were used. BL23 in acupuncture and CV12 in moxibustion were most frequently used. Gamisoyo-san in herbal medicine and visual analogue scale (VAS) in outcome measure were most frequently used.ConclusionsThis systematic review found encouraging but limited evidence of Korean medicine for FMS. I expect various trials such as randomized clinical trial or animal ex-perimentation and more case reports. And systemic review for FMS in other national jour-nals is needed. (J Korean Med Rehabil 2017;27(2):55-66)
  • 7.

    Current Status of Clinical Study on Traditional East Asian Medicine Using Taiwan Health Insurance Claim Data

    Chang-woon Jeung | Hee-Geun Jo | SUL JAE UK | 2017, 27(2) | pp.67~75 | number of Cited : 3
    ObjectivesThe study of the clinical effects of traditional east asian medicine (TEAM) us-ing Taiwan national health insurance claim dataset (NHIRD) is useful in Korean Medicine research. We reviewed the clinical studies of TEAM using NHIRD as a whole through this study.MethodsWe comprehensively searched PUBMED and NHIRD DB for clinical effects of TEAM study using NHIRD from inception to 17, January 2017. As a result, 40 studies in-vestigating the contribution of TEAM intervention to health benefit have been confirmed. We analyzed publication time, target disease, sample size, outcome measurement and main result of 40 searched studies.ResultsThe number of TEAM studies using NHIRD grdually increasing. The topics of the team study using NHIRD covered a wide range of subjects including cardiovascular dis-ease, tumor, gynecological disease, diabetes and kidney disease. The studies have shown large samples and reported significant effects on severe diseases.ConclusionsThe results of this study suggest that the study of Korean Medicine using Big data will be useful for decision making related to health care in Korea. However, consid-ering the limited domestic Korean health insurance data, it will be necessary to activate the big data research of Korean Medicine through the establishment of a separate cohort in Korea. (J Korean Med Rehabil 2017;27(2):67-75)
  • 8.

    Preliminary Study to Develop the Instrument on Pattern Identifications Knee Osteoarthritis

    Dong Hwi Jeon | Lee Eun Jung | 소현우 and 5other persons | 2017, 27(2) | pp.77~91 | number of Cited : 3
    ObjectivesThe aim of this study was to develop a standard tool of pattern identification for Knee Osteoarthritis, which will be applied to clinical research.MethodsThe advisor committee for this study was organized by 11 panel of experts (Korean Rehabilitation Medicine professors, Acupuncture and Moxibustion professors be-longing to Korean Medicine colleges, Principal Researcher of Korea Institute of Oriental Medicine, Doctor of Korean medicine). The pattern identifications and symptoms for this tool were extracted from published Korean and Chinese literature. Through the discussion among internal experts and consultation from advisors, the Instrument on Pattern Identifications for Knee Osteoarthritis was developed.Results1) Five pattern identifications (The Wind, Chill, and Moisture, The Moist-Heat, Blood Stasis, Yang Deficiency of Spleen and Kidney, Yin Deficiency of Liver and Kidney) were set for the tool. 2) The mean weights which represent the importance of each symp-tom and scored on a hundred-point scale was obtained. 3) The Instrument on Pattern Identifications for Knee Osteoarthritis was designed in the self-reporting format composed of 46 questions.ConclusionsThe Instrument on Pattern Identifications for Knee Osteoarthritis was cre-ated through this study. Though this study is not proved about validity, reliability, the instru-ment of pattern identification for Knee Osteoarthritis is meaningful and expected to be ap-plied to the subsequent. (J Korean Med Rehabil 2017;27(2):77-91)
  • 9.

    The Analysis of East-West Integrative Care System in a Korean Medicine Hospital Using by EMR Data: Preliminary Study

    Min Gu Kwon | Hee-Geun Jo | Jong-Hwan Kim and 4other persons | 2017, 27(2) | pp.93~99 | number of Cited : 5
    ObjectivesThe purpose of this study is to understand the condition of the Ease-West Integrative Care system in one of Korean Medical hospital, to develop more effective sys-tem, and to collect advance information for future research.MethodsWe analyzed patient’s status, patient’s composition and the ranking of the ma-jor disease code. In addition, we investigated the operating system of how Ease-West Integrative Care in hospitals is operating in order to grasp the actual situation is being done.ResultsAs a result of analyzing the status, there was a balanced cooperation between the Korean Medicine and Western Medicine with a ratio of 0.86:1. The disease status from Korean Medicine to Western Medicine were mostly occupied by stroke patients and from Western Medicine to Korean Medicine fragment were mostly by musculoskeletal pain patients.ConclusionsThe results of this study showed that the Ease-West Integrative Care sys-tem of surveyed Korean Medical hospital has more integrated medical characteristics than previous studies in terms of quality and quantitative. Future research based on detailed da-ta collection and review for a longer period is expected in the further. (J Korean Med Rehabil 2017;27(2):93-99)
  • 10.

    The Clinical Report on 3 Cases of Lateral Epicondylitis Treated with Musculotendinous Releasing Manual Therapy after Acupuncture Treatment

    Jaewon Park | 박서현 | 문소리 and 2other persons | 2017, 27(2) | pp.101~108 | number of Cited : 4
    We researched 3 patients diagnosed as Lateral epicondylitis (Tennis elbow). We consid-ered it as tendinosis including irregular collagen fiber’s pattern. So, acupuncture therapy and musculotendinous releasing manual therapy were used to treat the patients. We meas-ured their pain and functional disorder by visual analogue scale (VAS), Patient-Rated Tennis Elbow Evaluation (PRTEE), and a dynamometer before and after treatment. As a result, VAS and PRTEE significantly reduced and grasping power was also improved. Therefore, we conclude that the acupuncture therapy with musculotendinous releasing manual ther-apy is an effective way to treat Lateral epicondylitis. But there are limits on this study due to insufficient number of cases, absence of control group and absence of follow-up after last treatment. Further studies will be needed. (J Korean Med Rehabil 2017;27(2):101-108)
  • 11.

    Combination of Korean Medicine Therapy to Treat Posttraumatic Knee Stiffness: A Case Report

    Geon-Yeong Lee | SUL JAE UK | Hee-Geun Jo and 4other persons | 2017, 27(2) | pp.109~115 | number of Cited : 1
    The purpose of this study is to illustrate the potential for clinical improvement in treating a patient with a case of Posttraumatic Knee Stiffness with a combination of Korean medicine therapy. We treated the patient with acupuncture, electroacupuncture, CHUNA manual therapy and Interferential Current Therapy from 5th December 2016 to 13th January 2017 (total 29 times) by evaluating knee function with VAS score. After six weeks of treatment, this patient achieved effective outcome following the technique, showing that clinical symp-tom as able to walked and pain was relieved, VAS changed from 10 to 2 and the knee flex-ion ROM (active/passive) changed from 30/60 degrees to 120/140 degrees. This result shows that Korean Medicine therapy may be an effective option for Posttraumatic Knee Stiffness. Further clinical studies are needed to clarify the effect of Korean Medicine therapy on Posttraumatic Knee Stiffness. (J Korean Med Rehabil 2017;27(2):109-115)