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2018, Vol.28, No.3

  • 1.

    The Anti-obesity Effect of Seungyangjeseup-tang for High Fat Diet Induced Obese Mice

    Jung-Min Kim | Soo-Min Choi | Chang-Hoon Woo and 1other persons | 2018, 28(3) | pp.1~11 | number of Cited : 2
    Abstract
    Objectives This study was designed to evaluate the efficacy of Seungyangjeseup-tang on obesity by using 3T3-L1 cells and high fat diet mice. Methods In vitro, Seungyangjeseup-tang extract (SYJST) (10, 50, 100, 200, 400, 800μg/mL) ware added in 3T3-L1 cells. SYJST cytotoxicity was measured by 3-(4,5 -dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assasy. Adipocyte differentiation was measured by Oil Red-O staining. In vivo, the experimental animals were divided into five groups: normal diet-fed normal group (N), high-fat diet (HFD)-fed control group (Con), HFD+SYJST 100 mg/kg group (SY100), HFD+SYJST 200 mg/kg group (SY200), and HFD+olistat 60 mg/kg as a positive drug control group (Orli). Markers of obesity, such as body weight, liver weight, food intake, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), liver tissue TC, TG and fecal TC, TG were measured. Results In vitro, cytotoxicity was not significant compared with the control group. 3T3-L1 cell's differentiation was significantly decreased in Oil Red-O staining. In vivo, compared with controls, mice treated with SYJST demonstrate lower body and liver weight, and reduced food intake. In addition, SYJST increased TC, TG in the serum but not significance. And SYJST showed decreasing tendency TC, TG in the liver tissue. Furthermore, SYJST increased TC, TG in the facal but not significance. Conclusions Based on the results above, Seungyangjeseup-tang may reduce adipocyte differentiation, body fat, food intake, liver weight in obesity. This suggests that Seungyangjeseup-tang may be clinically useful in obesity treatment. (J Korean Med Rehabil 2018;28(3):1-11)
  • 2.

    Effects of Essential Oils Extracted from Cnidii Rhizoma on Differentiation and Adipogenesis in 3T3-L1 Adiopocytes

    Soo-Min Choi | So Young Kim | Na-Ri Park and 5other persons | 2018, 28(3) | pp.13~25 | number of Cited : 2
    Abstract
    Objectives We investigated anti-obesity effects of essential oils extracted from Cnidii Rhizoma (CR) in immature adipocytes to magnify it’s clinical therapeutic usage. Methods Essential oil of CR was extracted with ethyl acetate or petroleum ether and through steam distillation, respectively. Oil red-O staining for monitoring its inhibition effect on adipogenesis and differentiation in murine 3T3-L1 adipocytes and 3-(4,5-methylthiazol–2-yl)-2,5-diphenyletetra zolium bromide (MTT) assay for cell safety were done. Also phospho-adenosine monophosphate (AMP)-activted protein kinase (P-AMPK), AMP-activated protein kinase, phospho-acetyl-CoA carboxylase (P-ACC), acetyl-CoA carboxylase, peroxisome proliferator-activated receptor-α (PPAR-α), peroxisome proliferator-activated receptor-γ (PPAR-γ) and CCAAT/enhancer binding protein α (C/EBP-α) expressions as obesity-related factors were measured by western blot analysis. Results Protein expressions of P-AMPK, P-ACC and PPAR-α were increased in essential oils-treated adipocytes compared to those of control group, respectively. Furthermore, protein expressions of PPAR-γ and C/EBP-α were decreased in essential oils-treated adipocytes compared to those of control group, respectively. Conclusions These results demonstrate that essential oils of CR inhibit adipogenesis and differentiation. Also they promote the oxidation of fatty acids in adipocytes. Thus, results suggest that essential oils of CR could be used as a valuable material for anti-obesity therapeutics via control of lipid metabolism. (J Korean Med Rehabil 2018;28(3):13-25)
  • 3.

    Reviewing Research on Fracture Animal Experimental Study with Herbal Medicine Intervention in Korea

    Bong Seok Choi | Ji-Hyang Gu | Hyun-Ju Ha and 4other persons | 2018, 28(3) | pp.27~38 | number of Cited : 0
    Abstract
    Objectives The aim of this research is to analyze research trends on fracture animal experimental study in Korea. Methods For reviewing research, we constructed a key question as the effect of herbal medicine on fracture healing and selected fracture animal experimental research. We searched the following 6 databases: KoreaMed, Kmbase, Koreanstudies Information Service System (KISS), National Digital Science Library (NDSL), Korea Institute of Science and Technology Information (KISTI), Oriental Medicine Advanced Searching Integrated System (OASIS). Results A total of 283 potentially relevant studies were identified; only 12 studies were selected for reviewing research. Almost studies showed that herbal medicine had significant effect on fracture healing. Conclusions The research showed that herbal medicine could significantly stimulate fracture healing and reduced inflammation. In the future, more fracture animal experimental study should be actively conducted. (J Korean Med Rehabil 2018;28(3):27-38)
  • 4.

    Review of the Studies on the Influence of Experimental Arthritis Model of Herbal Medicine Extract

    Jonghan Park | Suhyeon Jeong | 2018, 28(3) | pp.39~53 | number of Cited : 1
    Abstract
    Objectives The aim of this study was to analyze the herbal prescription and composition of the leading experimental studies of herbal medicine extract in arthritis model and to analyze the way of setting model and the way of validating effect of the leading experimental studies of herbal medicine extract in arthritis model. Methods The Subjects were selected by select criteria and exclusion criteria from January 1, 2000 to September 30, 2017. The herbal prescription and composition of the selected subjects were analyzed. The effects and statistical significance of selected studies were verified by comparing the control and treatment groups of frequently used cytokines (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6). Results 52 kinds of herbal prescriptions and 118 kinds of individual herbs were used in 64 studies. Among the 52 kinds of herbal prescriptions, Daeganghwal-tang (4 times) was used most frequently. Among the 118 kinds of individual herbs, Glycyrrhizae Radix (49 times), Angelicae Giantis Radix (34 times), Osterici Radix (24 times) were used most frequently in order. The prescription that has the highest TNF-α decline is Changchooldoin-tang. The prescription that has the highest IL-1β decline is Banggibokryeong-tang. The prescription that has the highest IL-6 decline is Gwanjeol8ho-bang. Conclusions Daeganghwal-tang (herbal prescription) and Glycyrrhizae Radix, Angelicae Giantis Radix, Osterici Radix (individual herbs) were used most frequently. The prescriptions that have the highest cytokines decline were Changchooldoin-tang, Banggibokryeong-tang and Gwanjeol8ho-bang. (J Korean Med Rehabil 2018;28(3):39-53)
  • 5.

    A Systematic Review of Bee Venom Acupuncture for Ankle Sprain

    Gu jihyang | Yu Chen Li | Dong Chan Jo and 1other persons | 2018, 28(3) | pp.55~66 | number of Cited : 3
    Abstract
    Objectives To evaluate the evidence supporting the effectiveness of bee venom acupuncture for ankle sprain. Methods We conducted search across 11 electronic databases (Pubmed, EMBASE, Cochrane CENTRAL [CENTRAL], KoreaMed, Kmbase, Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], Korea Institute of Science and Technology Information [KISTI], China National Knowledge Infrastructure [CNKI], Wanfang and Chinese Scientific Journals Database [VIP] database) to find clinical trials that used bee venom acupuncture as treatment for ankle sprain. The methodological quality of randomized controlled clinical trials (RCTs) were assessed using the Cochrane Risk of Bias (RoB) tool, while non-randomized controlled clinical trials (NRCTs) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Four RCTs and one nRCT met our inclusion criteria. Almost studies showed that bee venom acupuncture has positive effect on ankle sprain. 4 studies of same intervention and control included in the meta-analysis. When comparing bee venom acupuncture and acupuncture with acupuncture, the effect size of standardized mean difference (SMD) was -0.19 (95% confidence interval [CI]: -1.95∼1.56, Z=0.55, p=0.83). And when comparing bee venom acupuncture with acupuncture, the effect size of SMD was -0.17 (95% CI: -0.65∼0.31, Z=0.71, p=0.48). Conclusions Although our systematic review found encouraging but limited evidence of bee venom acupuncture for ankle sprain, most of the studies included in the analysis were evaluated as methodologically high risk of bias. From now on further well-designed RCTs should be encouraged. (J Korean Med Rehabil 2018;28(3):55-66)
  • 6.

    A Survey on Satisfaction for Korean Medicine Treatments in 237 Traffic Injury Patients

    Hee-Ra Shin | Park Kyung-Tae | Muhack Yang and 3other persons | 2018, 28(3) | pp.67~78 | number of Cited : 9
    Abstract
    Objectives The purpose of this study is to carry out a survey on satisfaction for Korean medicine treatments in traffic injury patients. Methods Satisfaction survey was carried out on the 237 traffic injury patients who had been treated by Korean medicine treatments in Department of Korean Rehabilitation Medicine, Wonkwang University Gwangju Medical Center from February, 2017 to August, 2017. The questionnaire form of preceding study was used to assess the satisfaction degree of patients. All data were coded by SPSS v20.0 (IBM Corp., Armonk, NY, USA) and analysed by descriptive maneuver, x2-test, T-test and correlation. Results Among the 237 cases, the first hospital to be selected for traffic injury treatment was Korean medicine hospital in 91 cases. And 97 patients were transferred from the western medicine hospital. The main reason for choosing Korean medicine hospital was that the patients prefer Korean medicine treatments than western medicine treatments. 85.2.% of patients answered that their symptoms were improved, and 75.1% of patients answered that they were satisfied with Korean medicine treatments. The satisfaction degree of cupping treatment and acupuncture was relatively high, but the degree of Herbal medicine and physical treatment was relatively low. There were no statistically significant differences in satisfaction degree with sex and age. The satisfaction degree, improvement of symptoms, intention to revisit and intention to recommend was significantly correlated each other. Conclusions The degree of improvement of symptoms and The satisfaction degree were revealed relatively high. Additional and repetitive studies are needed to understand the patient's position and improve the quality of Korean medicine treatments for traffic accident patients. (J Korean Med Rehabil 2018;28(3):67-78)
  • 7.

    Difference of Improvement according to Hospitalization Time after Traffic Accident: A Retrospective Study

    Jeong-Ryol Lee | Yang-Sun Kim | Tae-Gyu Kim and 4other persons | 2018, 28(3) | pp.79~85 | number of Cited : 1
    Abstract
    Objectives The purpose of this study is to find a relation between hospitalization time and the overall outcome of treatment, and suggest an optimal hospitalization date. Methods We analyzed the medical records of patients who received admission treatment at Mokhuri Neck and Back Hospital in April, 2018. Results By analyzing the difference in visual analog scale (VAS) scores according to the hospitalization date, it was shown in this study that when hospitalization was held out by the fourth day of accident there was a significant difference in the improvement of symptoms than any other day. There were no statistically significant differences in initial VAS scores and admission periods. Conclusions It is the most effective for a traffic accident patient to receive hospitalization within the first four days of accident for the most effective reduction in overall pain. (J Korean Med Rehabil 2018;28(3):79-85)
  • 8.

    Korean Translation, Cross Cultural Adaptation of Whiplash Disability Questionnaire: Pilot Study

    Geon-Yeong Lee | Hee-Geun Jo | Shin Ae Kim and 4other persons | 2018, 28(3) | pp.87~96 | number of Cited : 0
    Abstract
    Objectives The purpose of this study is to provide more whiplash injury-specific measurement tools for Korean patients by measuring the validity and reliability of Korean version of Whiplash Disability Questionnaire (WDQ). Methods Bilingual clinicians translated the original WDQ into Korean. After consensus conference between researchers, it was back-translated into English. The pre-final version was completed and administered to 71 hospitalized patients diagnosed with whiplash injury. Validity was evaluated by concurrent validity. Reliability was assessed using Cronbach’s α and intraclass correlation coefficient. Results The Korean WDQ showed good reliability with high internal consistency and intraclass correlation coefficient (Cronbach's α=0.96, intraclass correlation coefficient [ICC]=0.82). Concurrent validity demonstrated positive correlations between Neck Disability Index, 36-Item Short Form Health Survey and WDQ. Conclusions The Korean version of WDQ is a valid and reliable tool for use as a measurement of whiplash injury in Korean patients, and it will be a very useful evaluation tool for both clinicians and researchers. (J Korean Med Rehabil 2018;28(3):87-96)
  • 9.

    The Clinical Effect of Rehabilitation Protocol for Distal Radius Fracture in Korean Medicine: A Report of 3 Cases

    Won-Bae Ha | Ji-Hye Geum | Nak-Yong Koh and 1other persons | 2018, 28(3) | pp.97~106 | number of Cited : 11
    Abstract
    The objective of this study was to propose a rehabilitation protocol for distal radius fracture in Korean Medicine and to report its effectiveness. Three patients who had undergone distal radius fracture were treated using the rehabilitation protocol in Korean Medicine. We estimated the outcome evaluating physical examination findings of the wrist joint, numeric rating scale and quick the Disabilities of the Arm, Shoulder and Hand (DASH) score. After the treatment, we observed that wrist movement, numeric rating scale and quick DASH score were improved. A rehabilitation in Korean Medicine can be effectively used for distal radius fracture patients. The limitation of this study was the insufficient number of cases. Further studies are needed to design a rehabilitation protocol in Korean Medicine. (J Korean Med Rehabil 2018;28(3):97-106)
  • 10.

    A Rehabilitation Protocol for High Tibial Osteotomy in Korean Medicine: A Report of 3 Cases

    Ji-Hye Geum | Ha WonBae | Nak-Yong Koh and 1other persons | 2018, 28(3) | pp.107~118 | number of Cited : 4
    Abstract
    In this study, we propose a rehabilitation protocol involving Korean medicine for patients after high tibial osteotomy (HTO) and report its effectiveness. Three patients underwent HTO using the rehabilitation protocol involving Korean medicine. We estimated the outcome evaluating physical examination findings of the knee joint, numeric rating scale, pain disability index, Lysholm knee score, and walking state. After the treatment, we observed that knee movement and muscular strength were improved. In addition, the numeric rating scale, pain disability index, Lysholm knee score, and walking state of patients were improved. Therefore, a rehabilitation protocol involving Korean medicine can be effectively used for patients after HTO. The limitation of this study was the insufficient number of cases and the difficulty of follow-up because of the characteristics of this operation and the long periods of time that are needed for each phase of the protocol. Further studies are needed to design a rehabilitation protocol involving Korean medicine. (J Korean Med Rehabil 2018;28(3):107-118)
  • 11.

    Three Adverse Events Reports of Simple Exanthematous Eruption after Sumsu (Bufonis Venenum) Pharmacopuncture Topical Treatment

    Sang-Hoon Yoon | Hee-Geun Jo | Min-Yeong Song and 1other persons | 2018, 28(3) | pp.119~124 | number of Cited : 3
    Abstract
    Three cases of simple exanthematous eruption were suspected during Sumsu (Bufonis Venenum) pharmacopuncture (SP) topical anesthesia for acupotomy. Patients had skin rash with pruritus on both ankle, posterior neck, and left shoulder after 11, 12, and 7 times of SP treatment, respectively. There were no cases of systemic manifestations or changes in vital signs. As a result of using the World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality assessment, all the cases were evaluated as 'unlikely'. However, the results of using the Korean algorithm for assessing the causality of drug adverse reactions version 2.0 were evaluated as 'possible'. This report is the first case report on adverse events suspected of occurring after SP treatment. Although the causal relationship between suspected intervention and the adverse event is not clear, there was a difficulty in completely excluding the possibility. Additional safety studies will be required to make SP more widely available. (J Korean Med Rehabil 2018;28(3):119-124)