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2019, Vol.29, No.4

  • 1.

    The Effect of Gyejibokryunghwan on Fracture Union in Tibia-fractured Rats

    Jeong-Won Yoon | Soon-Joong Kim | 2019, 29(4) | pp.1~14 | number of Cited : 1
    Abstract
    Objectives The object of this study was to assess the effect of Gyejibokryunghwan (GBH) on anti-oxidant and anti-inflammatory activities in RAW 264.7 cells and on factors associated with fracture union in tibia-fractured rats. Methods The 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity was measured to assess anti-oxidant activity. The production of nitric oxide (NO), interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the RAW 264.7 cells were measured to assess anti-inflammatory activity. The production of osteocalcin, calcitonin, carboxy-terminal telepeptides of type II collagen (CTXⅡ), transforming growth factor-β (TGF-β), bone morphogenetic protein-2 (BMP-2) in serum of tibia-fractured rats were measured to assess the effects of fracture union. X-rays were taken every two weeks from 0 to 4th week to assess fracture union effect. Results DPPH radical scavenging activity of GBH was increased according to concentration of GBH in RAW 264.7 cell. NO, prostaglandin E2 (PGE2), IL-6, IL-1β and TNF-α were significantly decreased, indicating anti-inflammatory effect. Osteocalcin, calcitonin, TGF-β were significantly increased in the experimental groups. CTXⅡ was significantly decreased in the experimental groups. BMP-2 was not significantly changed in the experimental groups. The X-ray showed that the experimental group has better healing effects on tibia-fractured rats than control group. Conclusions From above result, GBH has an effect on anti-oxidant, anti-inflammatory activities in RAW 264.7 cells. GBH showed significant results in factors related with fracture union and radiologic examination. In conclusion, GBH can help fracture union and it well be expected to be used actively in clinics. (J Korean Med Rehabil 2019; 29(4):1-14)
  • 2.

    Anti-obesity Effect of Crataegus pinnatifida through Gut Microbiota Modulation in High-fat-diet Induced Obese Mice

    Min-Jee Kim | Yura Choi | Na Rae Shin and 2other persons | 2019, 29(4) | pp.15~27 | number of Cited : 1
    Abstract
    Objectives This study was performed to evaluate anti-obesity effects of Crataegus pinnatifida (CP) on high-fat-diet induced obese mice. Methods The experimental animals were divided into four groups: normal diet (NOR) group, high fat diet (HFD) group, HFD+Xenical (XEN) group, and HFD+CP (CP) group. NOR group was fed a normal diet and the other three groups were fed high fat diet during the experiment. After the first two weeks of diet, XEN group and CP group were administered with XEN or CP for seven weeks, respectively. After that, we measured body weight, liver weight, fat weight, food intake, and serum concentrations of lipids and liver enzymes. Also the liver, intestine, fat tissue was removed to estimate the obesity-related mRNA expressions and the stool sample was collected to analyze the gut microbiota. Results We found that body weight, fat weight, and triglyceride level were decreased significantly in CP group compared to HFD group. Also CP significantly suppressed gene expressions associated with lipogenesis and inflammation, and increased gene expressions of browning of white adipose tissue and mitochondrial biogenesis. Moreover, it shifted the microbial diversity closer to that of NOR group and increased Firmicutes/Bacteriodetes ratio. Conclusions These results suggest that CP decrease body weight, fat weight and serum triglyceride. Also it inhibit inflammation and adipogenesis, altering gut microbial diversity and abundance. In conclusion, CP could be used as a therapeutic drug for obesity via gut microbiota modulation. (J Korean Med Rehabil 2019;29(4):15-27)
  • 3.

    Anti-obesity Effects of Banggihwnggi-tang-hap-yeonggyechulgam-tang in High Fat Diet Induced Obese Mice Model

    Tae-Ryeong Kim | Kim Youngjun | Chang-Hoon Woo | 2019, 29(4) | pp.29~45 | number of Cited : 0
    Abstract
    Objectives This study is to investigate anti-obesity effects of Banggihwanggitang-hap-yeonggyechulgam-tang (BY), an herbal formula, in high fat diet induced obese mice model. Methods Fourty five male C57Bl/6J mice were randomly assigned to normal group fed with normal research diet (Nor, n=9), high fat diet control group treated with water (Veh, n=9), high fat diet group treated with orlistat (Oris; n=9, Orlistat 40 mg/kg), high fat diet group treated with low concentraion BY (BYL; n=6, BY 0.87 g/kg) and high fat diet group treated with high concentration BY (BYH; n=6, BY 1.74 g/kg). Results Seven weeks later, antioxidative capacity, body weight, epididymal fat pad and liver weight, reactive oxygen species (ROS), peroxynitrite (ONOO-), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), superoxide dismutase (SOD), catalase, glutathione peroxidase (Gpx), heme oxygenase (HO)-1 and histology of liver were evaluated. In the BYH group, 1,1-diphenyl-2-picrylhydrazyl and 2,2'-azinobis (3 ethybenzothiazoline-6-sulfonic acid) radical scavenging activity were more than L-ascorbic acid. Body weight gain were significantly less than Veh group. Epididymal fat pad and liver weight gain were significantly less than Veh group. ROS and ONOO- were significantly less than with Veh group. ALT and AST were significantly less than with Veh group. Total cholesterol, triglyceride and LDL were significantly less, HDL were significantly more than Veh group. SOD, catalase, Gpx, HO-1 significantly increased compared with Veh group. Injury on liver was lesser than Veh group. Conclusions It can be suggested that BY has anti-obesity effects in high fat diet induced obese mice model. (J Korean Med Rehabil 2019;29(4):29-45)
  • 4.

    A Systematic Review of Herbal Medicine Treatment for Knee Osteoarthritis

    Ji-Hoon Kim | Youngsuk Yoon | Won Jun Lee and 2other persons | 2019, 29(4) | pp.47~60 | number of Cited : 3
    Abstract
    Objectives This study reviewed recent clinical research trends regarding the effectiveness of herbal medicine treatments for knee osteoarthritis. Methods We reviewed 4 different online databases (PubMed, China National Knowledge Infrastructure [CNKI], National Digital Science Library [NDSL], Oriental Medicine Advanced Searching Integrated System [OASIS]) from January 1, 2015 to August 31, 2019. Results Thirty-two randomized controlled trial papers were selected in this review. Most of them were conducted during 12 weeks, used Western Ontario and Mcmaster Universities Arthritis Index. In 22 of the papers, the effectiveness in the intervention groups was significantly higher than that in the control groups statistically (p<0.05). 5 studies reported intervention group was not inferior to the control group. Conclusions Most of studies showed herbal medicine treatments were statistically effective to knee osteoarthritis. More scientific and systematic clinical studies should be actively conducted in the future, and the results of this study could be used as basic data in the future clinical studies on herbal medicine treatment for knee osteoarthritis. (J Korean Med Rehabil 2019;29(4):47-60)
  • 5.

    Trend of Disabled Person Care for Establishment of Visiting Health Management Model for the Disabled

    Eun-Bi Kim | Jae-Won Lee | Sun-Young Park and 4other persons | 2019, 29(4) | pp.61~72 | number of Cited : 0
    Abstract
    Objectives We analyzed and organized present studies related to medical care for the disabled to establish an appropriate model of visiting health management for the people with disability. Methods To analyse study of medical care for the disabled, 11 electonic databases (PubMed, Chinese Academic Journals, EMBASE, Cochrane Library, Medline, Oasis, KMBASE, KISS, KISTI, NDSL, RISS) were searched from 2009 to 2018. There’s no limit to the type of study. Results The search showed 20 domestic studies and 113 foreign studies that were screened for final inclusion of 37 studies. The all of domestic studies were relevant to dental research. The foreign studies have reported on the treatment of underlying diseases and medical services for the disabled. Conclusions Most studies have reported that government institutional support were needed for systematic treatment of the disabled. In the future, institutional support would be needed to establish the model of oriental doctor’s visiting health management for the disabled. (J Korean Med Rehabil 2019;29(4):61-72)
  • 6.

    Development of Korean Version of Acute Concussion Evaluation using Cross-cultural Translation Methodology: Pilot Study

    Bomin Kim | Hee-Geun Jo | Ji-eun Koo and 7other persons | 2019, 29(4) | pp.73~79 | number of Cited : 0
    Abstract
    Objectives The purpose of this study is to provide Korean version of mild traumatic brain injury assessment tool. Methods The original version of acute concussion evaluation (ACE) was translated into Korean, and it was then back-translated into English without any prior knowledge of ACE. Finally, the pre-final version of Korean version of acute concussion evaluation (K-ACE) was derived. 49 Korean patients who had been diagnosed with mild traumatic brain injury participated in the study and completed K-ACE. Overall, 44 data were used to analyze findings. Validity of the study was assessed based on Concurrent validity. Reliability was also evaluated using Cronbach's α and the intraclass correlation coefficient. Results The Cronbach ’s α value for each item presented a proper level of internal consistency with results of 0.711 to 0.893 in two evaluations, respectively. The intraclass correlation coefficient of the retest reliability was marked as 0.892 (95% CI 0.840~0.933). Concurrent validity demonstrated positive correlations between K-ACE and Korean version of postconcussional syndrome questionnaire. Conclusions The K-ACE is concluded as a valid and reliable tool for measuring mild traumatic brain injury and post-concussion symptoms. Upon completion of the follow-up study, the K-ACE will be well-utilized by both clinicians and researchers. (J Korean Med Rehabil 2019;29(4):73-79)
  • 7.

    Comparison of Cervical Hyeopcheok Acupoint’s Depth Change with Cervical Rotation in a Prone Position: Protocol and Pilot Study Result for Accurate Observation of Cervical Hyeopcheok Acupoint by Ultrasonography

    Hongmin Chu | Park Kyung-Tae | Jang Jong-Won and 8other persons | 2019, 29(4) | pp.81~88 | number of Cited : 0
    Abstract
    Objectives This study is a preliminary study for safe and accurate cervical Hyeopcheok acupuncture by comparing the depth of cervical Hyeopcheok acupoint with cervical spine rotation. Methods Researchers took ultrasonographic images of cervical Hyeopcheok acupoint during full rotation of cervical spine, 45 degree rotation and neutral condition in a prone position. 4 healthy volunteers were recruited. Results No significant difference in needling depth of cervical Hyeopcheok acupoint was observed. However, there were a differences in anatomical structures’ shape such as muscles. Conclusions There are no significant difference in needling depth, but anatomical structures’ shape were changed. This result mean that if patient rotate cervical spine during acupuncture treatment, it can occur complications. Thus, when acupuncture treatment on cervical Hyeopcheok acupoint, practioner should make subject’s cervical spine alignment corrected and be careful not to change posture during the procedure. (J Korean Med Rehabil 2019;29(4):81-88)
  • 8.

    Analysis of Medical and Korean Medical Services Utilization after Lumbar Surgery Patients: Using Health Insurance Review and Assessment Service’s Patients Sample Data

    Sung-ae Ye | Nam-kwen Kim | SONG YUN KYUNG | 2019, 29(4) | pp.89~100 | number of Cited : 0
    Abstract
    Objectives We are going to analyze patient‘s medical and Korean medicine use trends after lumbar surgery, and examine the percentage of use of Korean medicine after surgery and its relevance to the medical care outcome after lumbar surgery. Methods Using 3% patients’ sample data of the Health Insurance Review and Assessment Service, two groups were compared the treatment progress of the Korean Medicine treatment group and the untreated group after lumbar surgery by hierarchical logistic regression analysis. After hierarchical logistic regression analysis(including propensity scores), two groups were compared after lumbar surgery, the Korean Medicine treatment group within 50days and untreated group within 50days. Results Lumbar surgery was performed in 2750 patients in 2015. It was 3.72 that the risk(odds ratio) of finished treatment of patients treated without Korean Medicine, compared to patients with Korean Medicine. It was 0.12 that the risk of continuing treatment(odds ratio) of patients treated with Korean Medicine within 50 days, compared to patients treatment more than 50 days. Conclusions The ratio of Korean Medicine treatment after lumbar surgery was 14.8%. The group that did not have Korean Medicine showed a higher possibility of treatment termination than the group who did not. Among the groups treated with Korean Medicine, the early treatment group was more likely to end treatment than the late treatment group. Considering various situations in the medical environment, further studies such as prospective studies and long-term data analysis are considered to be necessary. (J Korean Med Rehabil 2019;29(4):89-100)
  • 9.

    Safety of Gunghatang Tablet after Single Oral Administration in Healthy Male Volunteers, Single Center Study

    Sung-Hu An | Hee-Ra Shin | Park Kyung-Tae and 5other persons | 2019, 29(4) | pp.101~108 | number of Cited : 0
    Abstract
    Objectives The purpose of this study is to evaluate the safety of Gunghatang tablet in healthy male volunteers. Methods Single center pharmacokinetics study was carried out in healthy male volunteers. Through the laboratory test, vital sign and adverse event data, safety evaluation was conducted. Total 15 of 16 subjects who met the inclusion criteria were enrolled and three subjects were allocated to waiting group. 12 subjects were allocated by serial number according to registration order. Subjects took the maximum daily dose of the tablet on the second day of hospitalization. For the evaluation of safety, blood samples were collected and vital sign were checked 4 times (screening, before administration, after administration and follow up period) during the trial. All adverse events were recorded and summarized as frequency and percentage. All continuous data were summarized as mean and standard deviation. For comparison of variables between before administration and after administration, data were analyzed by paired T-test or Wilcoxon signed rank test (p<0.05). Results As a result of all data related to vital sign and laboratory test in both group, there were no significant differences associated with the clinical trial drug between pre and post administration. And there was no adverse event associated with the clinical trial drug. Conclusions Gunghatang tablet were found to be safe for healthy male volunteers. (J Korean Med Rehabil 2019;29(4):101-108)
  • 10.

    Clinical Study on 1 Case of Cervical Dystonia Treated by Korean Medicine and Transfer Energy Capacitive and Resistive (TECAR) Therapy

    Won Jun Lee | Youngsuk Yoon | Jongho Kim and 10other persons | 2019, 29(4) | pp.109~115 | number of Cited : 0
    Abstract
    Cervical dystonia (CD) is a disorder characterized by sustained or intermittent, involuntary muscle contractions which cause twisting, repetitive movements and abnormal postures. In this case report, a CD patients was treated with transfer energy capacitive and resistive (TECAR) therapy and conventional Korean medicine, which consists of acupuncture, Chuna manual medicine, pharmacopuncture and herbal medicine. For outcome measures, this study evaluated Cobb’s angle, EuroQol five dimension scale (EQ-5D), numerical rating scale (NRS), neck disabillity index (NDI) and cervical range of motion. As a result, improvements were found in Cobb’s angle (18.65°to 15.90°), EQ-5D score (0.808 to 0.862), NRS (5 to 3), NDI (16 to 8) and angle of cervical lateral bending (15° to 25°). In conclusion, this study shows that combined therapy of conventional Korean medicine treatment and TECAR therapy can be effective for CD patients. (J Korean Med Rehabil 2019;29(4):109-115)
  • 11.

    The Clinical Effects of Korean Medicine Rehabilitation Including Chuna Manual Therapy on Scapular Fracture Patient‘s Functional Recovery: A Case Report

    Jun-hyeong Bae | Junhyuk Ko | Seyoon Kim and 5other persons | 2019, 29(4) | pp.117~126 | number of Cited : 0
    Abstract
    To evaluate the effects of Korean medicine and Chuna treatment on patient with pain and limited range of motion (ROM) after scapular fracture. Patient was treated with Chuna manual therapy, acupuncture, herbal medicine, pharmacoacpuncture, cupping therapy and measured by ROM, visual analog scale (VAS), shoulder pain and disability index (SPADI), American shoulder elbow surgery scale (ASES), Korean shoulder score for instability (KSS). After the 3 weeks treatment, the patient's ROM, VAS, SPADI, ASES, KSS scores were improved. Rehabilitation program including Chuna manual therapy can be effectively used to improve scapular fracture patient's pain and symptom during rehabilitation period. Therefore it is recommended to use Chuna manual therapy for the improvement of movement and pain from fracture. (J Korean Med Rehabil 2019;29(4):117-126)
  • 12.

    Greater Trochanteric Pain Syndrome Managed with Korean Medicine Therapy: A Case Report

    Ji-hye Seo | Hee-Geun Jo | 2019, 29(4) | pp.127~134 | number of Cited : 0
    Abstract
    The Objective of this study is to report the results of greater trochanteric pain syndrome (GTPS) patient with Korean medicine therapy. There were insufficient clinical trials and case reports of GTPS treated with Korean medicine, we report the GTPS case remarkably improved treatment results. We treated the patient with acupuncture, acupotomy, pharmacopuncture, Chuna manual therapy and herbal medication. To evaluate the treatment effects, we used the measures including Verbal numerical rating scale, Oswestry disability index and Victorian Institute of Sport Assessment-gluteal tendinopathy scale. After total of 26 days of treatment, the patient’s hip pain and disability were greatly reduced, and the outcome measures showed this great improvement. Korean medicine therapy might be effective in GTPS, although further study is needed to determine the role for Korean medicine. (J Korean Med Rehabil 2019;29(4):127-134)
  • 13.

    A Case of Combined Korean Medicine Treatment for Recurrent Limb Weakness after Guillain-Barré Syndrome Improvement: Case Report

    Song-Mi Park | Sung-Woo Cho | 2019, 29(4) | pp.135~142 | number of Cited : 1
    Abstract
    The objective of this study is to propose Korean Medicine treatment for recurrent limb weakness after Guillain-Barré syndrome (GBS) improvement by intraveinous immunoglobulin, and to report its effectiveness. Manual muscle test (MMT), Korean modified Bathel index (K-MBI), and tendon reflex were used to evaluate the patient. The patient was improved hip joint, knee joint, ankle joint MMT from grade 3-/3- to grade 5/5 and in the upper limb the patient can do big joint exercise but cannot do micromovement like writing or using cell phone. When discharge date the patient's wrist joint MMT grade is improved grade 5-/5- to grade 5/5. The K-MBI score is improved from 71 to 86 and there was a big change in walking and chair/bed transfer, there was no change in tendon reflex. This study suggests that Korean Medicine can be effective for patients who have recurrent limb weakness after GBS improvement. (J Korean Med Rehabil 2019;29(4):135-142)
  • 14.

    The Clinical Effects of Complex Korean Medicine Treatment in Patient with Delayed Union of the 4th Toe Distal Phalanx Fracture

    Park Kyung-Tae | Hee-Ra Shin | Sung-Hu An and 2other persons | 2019, 29(4) | pp.143~149 | number of Cited : 0
    Abstract
    The purpose of this study is to report the effect in treating a patient with delayed union of 4th toe distal phalanx fracture with a combination of Korean Medicine treatment. We treated the patient with acupuncture, cupping, pharmacopuncture, moxibustion and herbal medicine, from March 3, 2018 to June 25, 2018 (total 33 times). The numeric rating scale (NRS), X-ray were applied as outcome measures. After complex Korean medicine treatment was carried out, delayed union of 4th toe distal phalanx fracture was improved and pain was reduced. This result shows that Korean medicine treatment may be an effective option for delayed union. Further clinical studies are needed to clarify the effect of Korean medicine treatment on delayed union. (J Korean Med Rehabil 2019;29(4):143-149)