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2020, Vol.30, No.2

  • 1.

    Antioxidative, Anti-inflammatory Effects of Jibaekjihwang-tang (zhibaidihuang-tang) on Osteoarthritic Rat Model

    Chang-Yoon Woo | Kim Youngjun | Chang-Hoon Woo | 2020, 30(2) | pp.1~18 | number of Cited : 0
    Abstract
    Objectives This study intended to evaluate antioxidative, anti-inflammatory effects of Jibaekjihwang-tang on monosodium iodoacetate (MIA)-induced osteoarthritic rat model and investigate the potential mechanism. Methods Jibaekjihwang-tang (100 or 200 ㎎/㎏ body weight) was orally administered once daily for 2 weeks days from day 7 after intra-articular MIA injection. And blood analysis, the histologic examinations were performed. Moreover, protein expressions related to anti-oxidant and cartilage degradation and anti-inflammatory cytokines were measured by western blot analysis in cartilaginous tissue. Results Jibaekjihwang-tang reduced serum inflammatory cytokines such as tumor necosis factors-α and interleukin-6. Furthermore, the increase of anti-oxidant enzymes reversed the oxidative stress caused by MIA. Meanwhile, Jibaekjihwang-tang suppressed MIA-induced inflammation and cartilage degradation in cartilaginous tissue. Conclusions Jibaekjihwang-tang alleviated MIA-induced inflammation. Jibaekjihwang-tang was associated with a protective effect on cartilage and by reducing inflammation and cartilage degradation. These findings provide new approaches for understanding osteoarthritis therapy. (J Korean Med Rehabil 2020;30(2):1-18)
  • 2.

    The Healing Effect of Jinmu-tang (Zhenwu-tang) in Femur Fractured Rats

    Jung-Oh Park | Minseok Oh | 2020, 30(2) | pp.19~35 | number of Cited : 1
    Abstract
    Objectives The aim of this study is to evaluate the fracture healing effect of Jinmu-tang (JM) on femur fractured rats. Methods Rats were randomly divided into 5 groups (normal, control, positive control, JM extract with low concentration and JM extract with high concentration). All group except normal group went through both femur fracture. Normal and control group received no treatment at all. Positive control group were medicated with tramadol (20 mg/kg) once a day for 14 days. Experimental group was orally medicated with JM extract (10 mg/kg for low concentration, 50 mg/kg for high concentration) once a day for 14 days. In order to investigate fracture healing process, plasma and serum were obtained. Also, micro-computed tomography was conducted to see the frature site visually. Immunohistochemistry for transforming growth factor-β1, Ki67, alkaline phosphatase, runt-related transcription factor 2, receptor activator of nuclear factor kappa-β, tartrate resistant acid phosphatase was conducted to observe bone healing progress after 14 days since fracture occured. Aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen and creatinine levels were measured in plasma, for hepatotoxicity and nephrotoxicity of JM extract. Osteocalcin was measured to observe activity of osteoblast. Results Through Micro-CT, more fracture healing was observed on both experimental group than control and positive control group. Through Hematoxylin & Eosin and safranin O staining showed bone cell proliferation and bone formation in the experimental group. RANK was significantly increased in the experimental groups. JM with high concentration showed statistically significant of TGF-β and Osteocalcin. NO, TRAP and ALP were not significantly changed. Liver toxicity was not significantly observed. Creatinine significantly increased in both experimental groups after 28 days. Conclusions As described above, JM extract showed anti-inflammatory effect, promoted fracture healing by stimulating the bone regeneration factor, and showed little hepatotoxicity and nephrotoxicity. In conclusion, JM extract can promote fracture healing and it can be used clinically to patients with fracture. (J Korean Med Rehabil 2020;30(2):19-35)
  • 3.

    Effects of Dioscoreae Rhizoma on Excercise Practice Ability and Blood Fatigue Variable Factor

    Na-Ri Park | Yun-Jin Lee | Eun-Byeol Lee and 3other persons | 2020, 30(2) | pp.37~46 | number of Cited : 0
    Abstract
    Objectives In this study, we analyzed the effect of Dioscoreae Rhizoma on exercise practice ability and blood fatigue variable factor in the forced swimming test. Methods Male mice were divided into four group. Mice were administrated with saline, Discorae Rhizoma extracted by water (DRW), Discorae Rhizoma extracted by 30% ethanol (DRE), red ginseng (RG), orally once per day, for 1 week. Exercise performance was evaluated by exhaustive swimming time and weights. Glycogen contents of liver and soleus muscle were measured at the end of the experiment. In addition, the biochemical parameters such as asparate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen, creatine, lactate dehydrogenase (LDH), ammonia, triglycerides (TG), total cholesterol (TC) and free fatty acid (FFA) were analyzed. Results Both DRW and DRE showed an improvement of swimming endurance compared with control group. Levels of ALT, ammonia, TG, TC and FFA were significantly decreased in both DRW and DRE compared with control group. Levels of AST, Creatine were significantly reduced in DRE group compared with control group. Moreover LDH showed only a tendency to increase in the DRW and DRE groups. Conclusions In summary, the present study showed that Dioscoreae Rhizoma improved in physical fatigue and exercise practice ability and DRE improved the superior than those of DRW. (J Korean Med Rehabil 2020;30(2):37-46)
  • 4.

    Experimental Study of Dohongsamul-tang (Taohongsiwu-tang) on Fracture Healing

    Hyun Ju Ha | Minseok Oh | 2020, 30(2) | pp.47~66 | number of Cited : 2
    Abstract
    Objectives The purpose of this study is to evaluate the bone healing effect of Dohongsamul-tang (Taohongsiwu-tang; DH) on femur fractured mice. Methods Mice were randomly divided into 4 groups (naive, control, positive control and DH). All groups except naive group were subjected to bone fracture on both hind limb femurs. Naive group received no treatment at all. Control group was fed with normal saline, and positive control group was orally medicated with tramadol. DH-treated group was orally medicated with DH. We analysed the levels of BMP2, COX2, Col2a1, Sox9, Runx2, and Osterix genes on 3, 7 and 14 days after fracture. Alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, total cholesterol, and triglyceride levels were measured for safety assessment. Results In morphological, histological analysis, callus formation process of DH-treated group was faster than the control group. BMP2, Sox9 gene expression were significantly increased at 7 days after fracture compared to the control group. COX2, Col2a1 gene expression were significantly increased at 14 days after fracture compared to the control group. Total cholesterol was significantly increased by DH at 3 days. Triglyceride was significantly decreased by DH at 3, 7 days after fracture compared to the control group. Conclusions Dohongsamul-tang promoted bone healing process after fracture by stimulating the bone regeneration factors. And DH shows no hepatotoxicity, nephrotoxicity and serum lipid abnormality. In conclusion, it seems that DH helps to promote fracture regeneration after bone fracture by regulating gene expressions related to bone repair. (J Korean Med Rehabil 2020;30(2):47-66)
  • 5.

    Antioxidant Activity and Standardization of Extraction Solvents of SJ004

    Dae-Yeon Lee | Ju-hwi Jo | Wan-su Kim and 5other persons | 2020, 30(2) | pp.67~75 | number of Cited : 0
    Abstract
    Objectives SJ004 is a natural herbal medicine that contains Acyranthes japonica Nakai and Eucommia ulmoides Oliver traditionally used for joint and spinal diseases. This study aimed to establish an efficient method of extracting SJ004 to standardize using the yield, high-performance liquid chromatography (HPLC), and antioxidant assay. Methods SJ004 was extracted with distilled water, 70% and 100% of ethyl alcohol (EtOH). The method validation of 20-hydroxyecdysone and pinoresinol diglucoside was determined by HPLC-photo diode array and the content of SJ004 was calculated. The antioxidant activity of each extract was compared and measured using total flavonoids, total phenolic compounds, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and ferric reducing antioxidant power according to the standard protocol. Results The yield was highest in pure water extract and lowest in 100% EtOH. But, the content of marker compounds indicating 20-hydroxyecdysone and pinoresinol diglucoside was highest in 100% EtOH extract. In the physiological activity measurement using antioxidant activity, 100% ethanol extract was highest. The limit of detection indicating 20-hydroxyecdysone and pinoresinol diglucoside were analyzed 0.33 μg/mL, 0.1616 μg/mL, and the limit of quantification were analyzed 1.01 μg/mL and 0.49 μg/mL respectively. Conclusions The experimental results showed that the extraction conditions have a significant effect on content of marker compounds and antioxidant activity. As a result of method validation, SJ004 was standardized by 20-hydroxyecdysone and pinoresinol diglucoside. (J Korean Med Rehabil 2020;30(2):67-75)
  • 6.

    A Review of Randomized Controlled Trial Studies during 5 Years for Treatment of Chondromalacia Patella Using China National Knowledge Infrastructure Database

    Yun-Young Choi | Su-Hyeon Yang | Yeong-Suk Jang and 6other persons | 2020, 30(2) | pp.77~93 | number of Cited : 0
    Abstract
    Objectives This study was conducted to investigate randomized controlled trial studies about clinical treatment of traditional Chinese medicine for chondromalacia patellae. Methods We searched randomized controlled trial studies about traditional Chinese medicine treatment for chondromalacia patella through China National Knowledge Infrastructure (CNKI). 27 articles published from 2015-2019 were finally chosen and analyzed by published year, number of samples, evaluation criteria, treatment duration, treatment method. Results Various treatments such as acupuncture therapy, herbal medicine, moxibustion therapy, manipulation, external treatment were practiced in China. Most of them were combined with western medicine or injection, rehabilitation therapy. Conclusions There were diverse studies about traditional Chinese medical treatment for chondromalacia patellae in China. In Korea, more clinical research about chondromalacia patellae is still needed. This study will be helpful for future research on Korean medicine for chondromalacia patellae. (J Korean Med Rehabil 2020;30(2):77-93)
  • 7.

    A Literature Review on the Use of Extracorporeal Shock Wave with Syndrome Differentiation Theory

    Lee Sang-Hyun | Hyun Tae Kim | Sun Young Park and 4other persons | 2020, 30(2) | pp.95~103 | number of Cited : 0
    Abstract
    Objectives This report aimed to review literatures using extracorporeal shock wave with syndrome differentiation theory. Methods By March 3, 2020, five foreign electronic databases (PubMed, Web of Science, Cochrane Library, EMBASE, CAJ) and six Korean medical electronic databases (KMBASE, KISTI, KISS, NDSL, DBpia, RISS) were reviewed with the key word ‘extracorporeal shock wave’ and ‘syndrome differentiation’. We did not impose restrictions on age, gender, treatment methods, duration, results and the design of the paper. Results Twelve papers met the inclusion criteria. Seven papers used extracorporeal shock wave lithotripsy with syndrome differentiation theory and six out of seven papers treated urologic stones using extracorporeal shock wave lithotripsy. The other five papers used extracorporeal shock wave therapy with syndrome differentiation theory and four of them treated musculoskeletal disorders. However, the data of the characteristics of extracorporeal shock wave was insufficient. Conclusions After thorough review, it is considered to be meaningful to treat urologic stones and musculoskeletal disorders using extercorporeal shock wave with syndrome differentiation theory. However, some of the literatures were limited in their feasibility and reliability in terms of research design. In addition, the data regarding the strength of the extracorporeal shock wave applied on each acupoints was insufficient. Therefore, further study on the use of extracorporeal shock wave on acupoints should be conducted. (J Korean Med Rehabil 2020;30(2):95-103)
  • 8.

    Effect of East-West Integrative Rehabilitation on Activities of Daily Living and Cognitive Functional Recovery in Stroke Patients: A Retrospective Study

    So Ri Moon | Keum Dong-ho | 2020, 30(2) | pp.105~123 | number of Cited : 1
    Abstract
    Objectives This study was conducted to verify the effectiveness of east-west integrative rehabilitation therapy on activity of daily living and cognitive functional recovery in stroke patients by comparing with integrative rehabilitation therapy group and conventional rehabilitation therapy group in a single institution. Methods The medical records of 106 stroke patients hospitalized in Department of Rehabilitation Medicine, Dongguk University Bundang Oriental Hospital from January 1, 2017 to February 28, 2019 were reviewed. After screening and dividing it into conventional rehabilitation (CR) group and integrative rehabilitation (IR) group, Korean version of Modified Barthel Index (K-MBI), functional independence measure (FIM), clinical dementia rating-sum of boxes (CDR-SB) were statistically analyzed. Results IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.001) and there was a statistically significant difference in K-MBI and CDR-SB score changes than CR group (p<0.05). And chronic patient of IR group showed significant improvement in K-MBI, FIM, and CDR-SB after treatment (p<0.01) and there was a statistically significant difference in CDR-SB score changes than CR group (p<0.05). In particular, the earlier the treatment initiation time, the more the improvement in function and when the treatment started within 2 years from the onset and patients took acupuncture and pulsed electromagnetic therapy, all scales significantly improved (p<0.001). Conclusions IR showed more improvement on activities of daily life and cognitive functional recovery than CR in this study. (J Korean Med Rehabil 2020;30(2):105-123)
  • 9.

    Correlation Study between Cervical X-ray Sagittal Parameters and Chuna Posture Analysis Results

    Joo-Sung Park | Lim Hyung Ho | SONG YUN KYUNG | 2020, 30(2) | pp.125~137 | number of Cited : 1
    Abstract
    Objectives The purpose of this study was to examine how changes in the cervical spine correlate with body posture changes in the whole body, and to find out the significance of complementary clinical application X-ray and Chuna posture analysis. Methods From January 1, 2019 to October 31, 2019, the results of 27 patients with pain in the vertebral region were analysed in accordance with the results of cervical X-ray and Chuna posture analysis. In order to confirm the significance of Chuna posture analysis results, the survey of 187 Chuna standard curriculum instruction qualification certifiers was conducted and the responses of 47 of them were analyzed. Results The occiput-atlas cline angle increases in both hypolordosis/hyperlordosis groups based on cervical lordosis angle, and increases further than in the hyperlordosis group. There were significant correlations between the changes in the cervical spine and the body posture changes in the whole body. There were no significant differences between cervical X-ray sagittal parameters and the body posture analysis parameters based on the patient's major disease codes. Conclusions As a result of conducting a survey on the clinical importance of the body posture analysis parameters, the importance of cervical parameters was verified. Changes in the cervical spine may not only cause other changes in the cervical region, but also affect the body posture changes in the whole body. The complementary application of X-ray and Chuna posture analysis results is helpful in clinical diagnosis and treatment of musculoskeletal disorders. (J Korean Med Rehabil 2020;30(2):125-137)
  • 10.

    A Survey on Patient's Experience on Health Care Utilization and Perception of Health Care System for Developing of a Korean Medicine Clinical Practice Guideline for Traffic Injuries

    Sun Young Park | Lee Sang-Hyun | Heo, In and 6other persons | 2020, 30(2) | pp.139~152 | number of Cited : 1
    Abstract
    Objectives To explore the traffic injury patients’ experience on health care utilization of Korean Medicine (KM) practice and perception of health care system for developing a Korean medicine clinical practice guideline (CPG) of traffic injuries by survey method. Methods Two hundred ten patients in suffering from traffic injuries were surveyed from September 1st, 2019 to January 31th, 2020 at 2 University Hospitals (Pusan National Korean Medicine Hospital and Kyung Hee Korean Medicine Hospital at Gangdong) and 1 Spine Specialty Hospital (Jaseng Hospital of Korean Medicine). A structured questionnaire of experience on health care utilization of KM practice and perception of health care system of was distributed to responders by visits and all data were statistically analysed. Results Survey results showed high satisfaction of patients with the experience of KM treatments in order of daoyin exercise (7.8±2.3), chuna manual therapy (7.7±4.0), pharmacoacupuncture (7.4±3.0) etc. Safety concerns were reported in 9.1% subjects and 205 (97.6%) patients answered that collaboration with KM and western medicine is necessary for patients with traffic injuries. For the patients’ requirement for extending insurance coverage, the most required therapy was chuna manual therapy (57.5%) and pharmacoacupuncture (42.0%). Conclusions This study presented the realistic patient-centered perception of KM practice and health care system in Korea. These results will provide basic data to be reflected in the process of adaptation for the revision of Korean Medicine CPG for traffic injuries. (J Korean Med Rehabil 2020;30(2):139-152)
  • 11.

    Safety of Soshihotang Soft Extract after Single Oral Administration in Healthy Male Volunteers, Single Center Study

    Sung-Hu An | Park Kyung-Tae | Seung-ryong Yeom and 2other persons | 2020, 30(2) | pp.153~164 | number of Cited : 0
    Abstract
    Objectives This study is designed to evaluate the safety of Soshihotang soft extract in healthy male volunteers. Methods 12 healthy male volunteers were recruited and this study was carried out by a single center. Laboratory test results, vital signs of the volunteers were collected to evaluate safety. According to registration order, the 12 subjects were allocated by serial number. To evaluate safety, blood samples were taken and vital signs were checked 4 times-screening, pre administration, post administration and follow up-during the whole trial. The incidence of all adverse effects are shown in percentage. The mean and standard deviation were used to to describe and summarize continuous data. To evalate the effectiveness of the intervention, data of blood tests was analyzed by Wilcoxon signed rank test or paired T-test (p<0.05). Results In the case of red blood cell, hemoglobin, hematocrit, neutrophils, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase values, the normality test result of the variable for the difference value before and after the dosing has a significance level <0.05. But most of values did not deviate from the normal range, and the deviation from the normal range could not be regarded as the significance associated with this clinical trial. And adverse event wasn’t observed associated with the clinical trial drug. Conclusions Soshihotang soft extract were considered to be safe for healthy male volunteers. (J Korean Med Rehabil 2020;30(2):153-164)
  • 12.

    Korean Medicine Treatment for Developmental Dysplasia of the Hip in Adults: A Case Report

    Eui-Byeol Kim | Kiwan Kang | Min-Woo Kim and 2other persons | 2020, 30(2) | pp.165~171 | number of Cited : 0
    Abstract
    The purpose of this study is to report the effect of korean medicine treatment for developmental dysplasia of the hip (DDH) in adults. A patient diagnosed with DDH had been treated with acupuncture, electroacupuncture, cupping therapy and chuna manual therapy for 8 weeks. The patient was evaluated by using range of motion (ROM) of hip joint, muscle strength of lower extremity, leg length, numeric rating scale (NRS) and Korean version of hip disability and osteoarthritis outcome score (K-HOOS). After the treatment, the patient had an improvement in the symptoms, pain, and activities of daily living of K-HOOS, especially the quality of life. In addition, NRS decreased from 7 to 4 points, and ROM and muscle strength also improved. The results of this study show that korean medicine treatment is effective and meaningful as one of the conservative treatment for DDH in adults. (J Korean Med Rehabil 2020;30(2):165-171)
  • 13.

    A Case of Idiopathic Peripheral Neuropathy Improved by Combined with Electroacupuncture and Bee Venom Acupuncture

    Sunjoo An | Seonghwan Choi | Shinwoo Kang and 2other persons | 2020, 30(2) | pp.173~181 | number of Cited : 0
    Abstract
    The purpose of this study is to report the effects of electroacupuncture and bee venom (BV) acupuncture for a patient suffering with idiopathic peripheral neuropathy. There was a one patient who was diagnosed as idiopathic peroneal neuropathy and tibial neuropathy received electroacupuncture and BV acupuncture at acupoints on peroneal and tibial nerve pathway. The evaluation of clinical outcome was done by range of motion (ROM), manual muscle test (MMT), perimeter of lower leg, neuropathy pain scale (NPS). After treatment, the patient showed improvement in ROM and MMT. The patient’s perimeter of lower leg was increased, NPS was decreased. This study suggests that the treatment of acupoints on the damaged nerve pathways could be an effective treatment for peripheral neuropathy, although further studies will be needed. (J Korean Med Rehabil 2020;30(2):173-181)