Effects of Bee-venom(BV) and Cheongyeolsaseup-tang(Qingrexieshi-tang) onType Ⅱ Collagen-Induced Arthritis

정순구; Jin-Bong Choi; 설재욱

Journal of Korean Medicine Rehabilitation

Abbr : JKMR
2006, 16(3), pp.17-33
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Korean Medicine

정순구 ¹, Jin-Bong Choi ², 설재욱 ³

¹동신대학교
²동신대학교
³동신대학교

ABSTRACT

Objectives : This study was carried out to investigate the effects of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract on type Ⅱ collagen-induced arthritis rats. Then, we compare separateness with combination of Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang). Methods : We observed inhibitory effect of edema, analgesic effects by hot plate, analysis of blood chemistry(WBC, ALT, AST), western blot(IL-6, cPLA2), histopathological and radiological changes. Results : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) extract significantly inhibited the rate of paw edema compared with control group and reduced WBC, the time of heat threshold, AST(Asparatate transaminase), ALT(Alanine transaminase), the mass of IL-6, cPLA2 in synovia compared with control group in immunological test. On the histopathological view, all experimental groups were relieved and reproduced the erosion of arthritic site compared with control group. On the radiological view, all experimental groups were improved. Conclusions : Bee-venom and Cheongyeolsaseup-tang(Qingrexieshi-tang) can be used for curing rheumatoid arthritis. Anti-inflammatory effects may be somewhat better in combination of BV and CST.
KEYWORDS

Bee-venom, Cheongyeolsaseup-tang(Qingrexieshi-tang), Type Ⅱ collagen-induced arthritis
REFERENCES (29)

[journal] / 1995 / Synthesis and degradation of hyaluronate by synovia from patients with rheumatoid arthritis 22 : 400~405

[journal] / 1997 / HARRISON'S 내과학 / 도서출판 정담 : 590 ~

[journal] / 1996 / Phagocytic lining cells determine local expression of inflammation in type Ⅱ collagen-induced arthritis / 39 : 1545~1555

[journal] / 1994 / Collagenase로 유발한 백서 슬관절의 퇴행성 병변에 관한 형태학적 연구 6 : 3~15

[journal] / 1933 / Interleukin-1-mediated phospholipid breakdown and arachidonic acid release in human synovial cells : 158~67

[journal] / 1993 / 류마티스 관절염의 정의와 원인 : 29~33

[journal] / 1998 / 봉독약침의 항염증 작용에 관한 실험적 연구 15(1) : 317~331

[journal] / 1972 / 自由版出版社

[journal] / 1978 / Cellular sensitivity to collagen in rheumatoid arthritis : 327~32

[journal] / 1976 / A refined and sensitive method for the quantitiation of microgram quantities of protein utilizing the principle of protein-dye binding 72 : 248~254

[journal] / 1987 / Poole Preteoglycan-induced arthritis in histopathology : 201~212

[journal] / 1995 / 류마티스 관절에서 유래된 B-림프구선의 항체 경사슬 가변부 유전자에 관한 연구 17(1) : 65~72

[journal] / 2002 / Rheumatoid arthritis: a molecular understanding 136 : 908~922

[journal] / 1994193-200 / Mechanism of methotrexate action in rheumatoid arthritis

[journal] / 2000 / 암관련 봉독연구에 대한 고찰 17(4) : 69~78

[journal] / 2000 / 통증 관련 봉독연구에 대한 고찰 3(1) : 157~175

[journal] / 2004 / 봉독약침과 Melittin이 RAW 264 7 세포의 NO, iNOs 및 MAPK에 미치는 영향 21(3) : 107~119

[journal] / 2003 / 蜂毒藥鍼療法 / 경희대학교출판국 13(1) : 283~292

[journal] / 1992 / A limited arthritis model for chronic pain studies in the rat : 73~81

[journal] / 2000 / 關節炎에 관한 韓醫學碩博士論文 73編에 대한 分析 : 96~

[journal] / 1991 / on various models of rheumatoid arthritis / Immunosuppressive activity 15-deoxyspergualin : 15 471~83

[journal] / 1998 / Effect of Vernonia cinerea Less flower extract in adjuvant: induced arthritis 31(4) : 601~606

[journal] / 1993 / Behavioral and immunohistochemical changes in an experimental arthritis model in rats : 367~377

[journal] / 2000 / Increased synovial fluid lecels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies 11 : 669~676

[journal] / 1998 / Study of pro-inflammatory (TNF-alpha, IL-alpha, IL-6) and T-cell-derived (IL-2, IL-4) cytokine in plasma and synovial fluid of patients with juvenile chronic arthritis: correlation with cllinical and laboratory parameters 17 : 288~292

[journal] / 2000 / Capsaicin inhibits platelet activating factor-induced cytosolic Ca2+ increase and superoxide production / 165( ) : 3992~3998

[journal] / 2003 / 봉약침액이 Raw 264.7 세포의 PLA2 및 Calcium Concentration에 미치는 영향 6(2) : 149~158

[journal] / 1991 / Quantification and kinetics of poly morphonuclear liukocyte and lymphocyte accumulation in joints during adjuvant arthritis in rat : 436~447

[journal] / 1992 / The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats : 235~243
KCI Citation (0)

KJC Korea
Journal Central

Statistics

Tools