Inhibitory Effect of Kuseupbokhap-bang on (Q&ugrave;shīf&ugrave;h&eacute;-fāng)Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes

한주원; Minseok Oh; Yoon il ji; 송영일

Inhibitory Effect of Kuseupbokhap-bang on (Qùshīfùhé-fāng)Rheumatoid Arthritis in Human Fibroblast-like Synoviocytes

Journal of Korean Medicine Rehabilitation

Abbr : JKMR
2006, 16(3), pp.1-16
Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
Research Area : Korean Medicine

한주원 ¹ , Minseok Oh ² , Yoon il ji ³ , 송영일 ⁴

¹ 대전대학교
² 대전대학교
³ 대전대학교
⁴ 대전대학교

ABSTRACT

Objectives : This study was carried out to know the inhibitory effect of Kuseupbokhap-bang(Qùshīfùhé-fāng; KC) on rheumatoid arthritis in human fibroblast-like synoviocytes(hFLSs). Methods : For this purpose, experiments were performed to measure the cytotoxicity against hFCs and the production of pro-inflammatory cytokines in hFLSs and the production of NO, ROS. Results : KC had no cytotoxicity against hFCs and reduced the production of pro-inflammatory cytokines TNF-α, IL-6, IL-8, IL-1β in hFLSs, increased the production of TIMP-1. As well as KC reduced the production of MMP-3, NOS-II, ICAM-1, the production of Nitric oxide and ROS, and the proliferation of hFLSs in proportion to the concentration of KC significantly. Conclusions : Comparison of the results for this study showed that KC had immunomodulatory effects of suppressing or enhancing.
KEYWORDS

Kuseupbokhap-bang(Qshfh-fng) , Rheumatoid arthritis , Immunomodulatory , Immunity , Collagen-induced arthritis(CIA) mice.
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