Objectives To review the epigenetic modifications involved in chronic pain and to improve individualized intervention for the chronic pain.
Methods Focused literature review.
Results Significant laboratory and clinical data support that epigenetic modifications have a potential role for development of chronic pain.
Conclusions Epigenetic approach may identify mechanisms critical to the development of chronic pain after injury, and may provide new pathways and target mechanisms for future treatment and individualized medicine. (J Korean Med Rehabil 2020; 30(1):63-78)