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pISSN : 1229-1854

2020 KCI Impact Factor : 0.78
목적과 범위
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한방재활의학과학회지는 한방재활의학과학회의 공식 학술지입니다. 1996년 창간되었으며, 한방재활의학연구 분야의 원저(original article), 종설(review), 임상 및 증례보고(clinical and case report), 단신보고(brief report) 등이 게재됩니다. 학회지는 매년 1월, 4월, 7월, 10월에 발행됩니다. 학회지 정식 명칭은 'Journal of Korean Medicine Rehabilitation'이고 약칭은 'JKMR'이며 제출된 모든 원고는 세 명의 심사위원이 동료 검토하게 됩니다. 논문은 한국어 또는 영어로 작성될 수 있고, 초록과 참고문헌은 영어 기재가 원칙입니다. 이 학회지는 한국 인용 지수(KCI)에 색인되어 있습니다. 구독, 제출 및 기타 모든 정보를 보려면 학회지 공식 홈페이지를 방문하십시오. 홈페이지의 URL 주소는 http://www.e-jkmr.org/입니다. 이 학술지는 한국 정부가 지원하는 한국과학기술단체총연합회 보조금으로 지원됩니다.
편집위원장
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송용선 (원광대학교 한방재활의학과)
인용지수
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  • KCI IF(2년) : 0.78
  • KCI IF(5년) : 0.67
  • 중심성지수(3년) : 0.719
  • 즉시성지수 : 0.1818

최근발행 : 2020, Vol.30, No.4

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  • 경골 파혈산동탕(破血散疼湯)이 골절 생쥐의 골 유합에 미치는 영향

    신우석 | Kira Parichuk | 차윤엽 | 2020, 30(4) | pp.1~16 | 피인용수 : 0
    초록
    Objectives The main purpose of this study was to evaluate the bone healing effect of Pahyeolsandong-tang (PHT)(Poxiesanteng-tang) extract in tibia fracture-induced mice. Methods PHT was extracted using a solution of 35% ethanol in 60°C for 8 hours. Mice were randomly divided into 4 groups (normal, control, PHT 50 and PHT 100). Mice of experimental groups were medicated with PHT 50 or 100 mg/kg for 7 to 21 days. To clarify the effect of bone fracture healing, relative messenger RNA (mRNA) expressions of osteocalcin (OCN), runt-related transcription factor 2 (Runx2), osterix (OSX), Sox9, collagen type Ⅱ alpha 1 chain (Col2a1), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) were examined. Results In in vitro experiment, relative mRNA expression of OCN, Runx2, Col2a1 was significantly increased in PHT treated group to compare with control differentiation group. In in vivo experiment, relative mRNA expression of OCN, Runx2, OSX, Sox9, Col2a1, RANKL, OPG was significantly increased in PHT treated group. Conclusions This study showed that PHT accelerates bone fracture healing through the activation of osteoclasts and osteoblasts. It was showed that PHT significantly promotes osteoblasts differentiation by osteoblast differentiation markers such as OCN, Runx2, Col1a2. Also it was investigated that PHT had stimulatory effect on osteoblasts function through enhancing OCN, Runx2, OSX, Sox9, Col2a1 and, osteoclasts function through enhancing RANKL and OPG markers. PHT effectively promotes bone fracture healing process through activation of osteoblasts and osteoclasts. (J Korean Med Rehabil 2020;30(4):1-16)
  • 六味地黃湯이 대퇴골절 동물모델의 골절 유합인자 및 형태학적 변화에 미치는 영향

    김현석 | 전동휘 | 오민석 | 2020, 30(4) | pp.17~30 | 피인용수 : 0
    초록
    Objectives The purpose of this study is to evaluate the healing effect of Yukmijihwang- tang (YM) on femur fractured mice. Methods Mice were randomly divided into 6 groups: normal, control, positive control, YM with low, medium, high dosage each. All groups were prepared with femur fracture and treated diffrently. In order to measure bone regeneration effects, we analysed the levels of cyclooxygenase-2 (COX2), bone morphogenetic protein-2 (BMP2), collagen type Ⅱ alpha 1 chain (Col2a1), Sox9, runt-related transcription factor 2 (Runx2), and osterix genes expressed in bone. For morphological analysis, muscles were removed and femur was observed with naked eye. Results COX2 gene expression in bone marrow significantly decreased. BMP2 gene expression significantly increased. Col2a1 gene expression significantly increased. Sox9 gene expression increased as well. Runx2 gene expression in bone marrow increased, but there was no statistical significance. Osterix gene expression significantly increased. Union of the fracture site progressed more in YM group compared to the control group. The fracture union score was significantly decreased in YM group compared to the control group. Conclusions YM showed anti-inflammatory effect, promoted bone regeneration by stimulating the bone regeneration factor. In conclusion, YM can help fracture healing and it well be applied clinically to patients with fracture. (J Korean Med Rehabil 2020;30(4):17-30)
  • 추출법에 따른 당귀수산과 작약감초탕의 성분과 활성의 비교

    이대연 | 이호성 | 조주휘 외 6명 | 2020, 30(4) | pp.31~39 | 피인용수 : 0
    초록
    Objectives Danggwisoo-san and Jakyakgamcho-tang are frequently prescribed for traffic accident patients in Korea. The aim of this study was to examine index compound analysis, antioxidant activity and amount of starch measurement by extraction method. Methods Danggwisoo-san and Jakyakgamcho-tang were extracted with water and 70% ethanol. Antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazyl, 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and ferric reducing antioxidant power according to the standard protocol. The contents of the indicator components nodakenin, paeoniflorin, and glycyrrhizin were measured by high-performance liquid chromatography, respectively. All starches were hydrolyzed and then total D-glucose was measured and compared. Results Antioxidant activity was excellent in 70% ethanol in all assays. The index component was jagged because its solubility was different depending on the extraction solvent. Starch content was significantly lower in 70% alcohol extract than water extract. Conclusions The results of this study showed that physiological activities and components are different according to extraction conditions. Each herbal medicine has a suitable extraction solvent. Also, the difference in starch content is an object to be considered as it may affect digestion and absorption. (J Korean Med Rehabil 2020;30(4):31-39)