Korean | English

pISSN : 1976-9334 / eISSN : 2288-1522

2020 KCI Impact Factor : 1.63
Home > Explore Content > All Issues > Article List

2009, Vol.9, No.1

  • 1.

    The Role of Gut Microbiota in Obesity and Utilization of Fermented Herbal Extracts

    박정현 | 김호준 | Myeong-Jong Lee | 2009, 9(1) | pp.1~14 | number of Cited : 23
    Abstract
    Complex microbial communities play an important role in the human health and co-evolved with human in the form of symbiosis. Many literatures provide new evidences that the increased prevalence of obesity cannot be attributed solely to changes in the human genome, nutritional habits, or reduction of physical activity in our daily lives. The intestinal flora was recently proposed as an environmental factor responsible for the control of body weight and energy metabolism. A number of studies suggest that the modulation of gut microbiota affects host metabolism and has an impact on energy storage and demonstrated a role for the gut microbiota in weight gain, fat increase, and insulin resistance. Variations in microbiota composition are found in obese humans and mice and the microbiota from an obese mouse confers an obese phenotype when transferred to an axenic mouse. As well, the gut microbial flora plays a role in converting nutrients into calories. Specific strategies for modifying gut microbiota may be a useful means to treat or prevent obesity. Dietary modulations of gut microbiota with a view to increasing bifidobacteria have demonstrated to reduce endotoxemia and improve metabolic diseases such as obesity. The fermentation of medicinal herbs is intended to exert a favorable influence on digestability, bioavailability and pharmacological activity of herbal extract. Therefore we also expect that the fermented herbal extracts may open up a new area to treat obesity through modulating gut microbiota.
  • 2.

    Recent Topics of Clinical Trials in Obesity And Metabolic Study

    이주아 | Kong, Kyung-Hwan | 고호연 and 9other persons | 2009, 9(1) | pp.15~22 | number of Cited : 4
    Abstract
    Objectives The aim of this study is to review and analyze the status on the recent clinical trials of 'obesity' and 'metabolic syndrome'. Methods We search 'www.clinicaltrail.gov' for research trend of obesity and metabolic syndrome. Search terms used were 'obesity' and 'metabolic syndrome'. In order to see detail review, searching was performed from 01, 01, 2007 to 05, 31, 2009 with intervention, phase Ⅲ or phase Ⅳ. And we classified all the searched studies into design, intervention, purpose, end point, diseases and condition. Results We could search total 232 trials. Of them, we found 32 trials with intervention, phase Ⅲ or phase Ⅳ from 01, 01, 2007 to 05, 31, 2009. Also we could see various design of clinical trials. Conclusion To improve obesity and metabolic study in Traditional Korean Medicine, it is need to activate clinical trial, meta analysis, develope of clinical practice guidelines, co-works with conventional medicine and etc.
  • 3.

    Review on the Research Relative to Taeeumjowui-Tang(Taiyintiaowei-tang)

    Kyungmoo Park | SONG YUN KYUNG | Lim Hyung Ho and 7other persons | 2009, 9(1) | pp.23~36 | number of Cited : 9
    Abstract
    Objectives The purpose of this study is to research related to Taeeumjowui-Tang(Taiyintiaowei-tang) in oriental medicine. Methods "Taeeumjowui-Tang" was used as a search term. In order to see detail review, we classified all the searched study into type, method, purpose, item of evaluation, composition of herbal medication. Results We found out total twenty six studies. They were fifteen pieces of experimental studies, five clinical case studies, five case reports and one literature review according to type and method. There were fourteen thesis that experiments on efficacy and effect in the purpose of study. Only one thesis showed about stability and toxicity. There were eleven prescription of different composition and dosage. In the item of evaluation, serum biochemical analysis, cell study, body and organ weight, food consumption, body mass index, waist circumference, waist-hip circumference ratio, bioelectrical impedance analysis were used. Conclusion To improve more objective and continuous research in oriental medicine, it is needed unity about prescription and dosage, activation of clinical trial research and variation of research subject.
  • 4.

    The Comparison of Pattern Identification Diagnosis According to Symptom Scale Based on Obesity Pattern Identification Questionnaire

    강경원 | 문진석 | Byoungkab Kang and 3other persons | 2009, 9(1) | pp.37~44 | number of Cited : 18
    Abstract
    The study was to investigate the distribution for the diagnosis of pattern identification based on obesity pattern identification questionnaire and agreement rate between the diagnosis of pattern identification based on obesity pattern identification questionnaire and the clinical diagnosis of pattern identification by medical specialist. The distribution for the diagnosis of pattern identification based on obesity pattern identification questionnaire was shown in order of stagnation of liver Gi, retention of undigested food, deficiency of Yang at scale of 5, 3, 2 score and the diagnosis rate of single pattern identification at scale of 5, 3, 2 score was 89.96%, 79.33%, 54.64%, respectively. the agreement rate between the diagnosis of pattern identification based on obesity pattern identification questionnaire and the clinical diagnosis of pattern identification by medical specialist was 0.1013. Therefore, the complementary management in CRF questionnaires with consultation from experts and the study for score difference of pattern identification will improve the accuracy and agreement rate, which will be helpful for pattern identification of obesity by clinical experts.
  • 5.

    The Effect of Management Program of Oriental Medicine for Obesity Control on Overweight and Obese Pediatrics

    이윤재 | 류은경 | 2009, 9(1) | pp.45~51 | number of Cited : 3
    Abstract
    Objectives The purpose of this study was to investigate the effect of oriental treatment on pediatric overweight and obesity. Methods From the December 2006 to the May 2008, 19 children were treated of obesity control in J Korean Hospital. Herbal medicine, electrolipolysis, auricular acupuncture was done 2 times per week for 4 weeks with the consulting of diet and exercise. Nine children were treated for 9 weeks. We checked the change of weight at treatment time and the body composition measured by bioelectrical impedance analysis(BIA) per 2 weeks. Results After 4 weeks treatment, the weight loss was 2.67±1.75kg. And after 9 weeks treatment, the weight loss of 9 children was 5.91±2.73kg. Total fat mass measured by BIA significantly decreased 2.38±1.19kg after 4 weeks. BMI and the weight loss of children were significantly correlated. After 4 weeks treatment the BMI significantly decreased 1.43±0.89kg/m2. After 8 weeks treatment the BMI of 9 children significantly decreased 3.31±1.47kg/m2. Conclusions The pediatric obesity could be effective treated by herdal medicine and electroacupuncture.
  • 6.

    The Change of Weight Loss of Oriental Obesity Treatment

    이윤재 | 류은경 | 2009, 9(1) | pp.53~58 | number of Cited : 4
    Abstract
    Objectives The purpose of this study was to investigate the clinical effect of oriental medical therapy on obesity and the progress of weight loss through an oriental obesity program. Methods The subjects were treated from January 2008 to February 2009 in J Korean Medical Hospital. Herbal medicine, electrolipolysis, auricular acupuncture were performed during the treatment period. We checked the change of weight every treatment time and measured the body composition by bioelectrical impedance analysis(BIA) every 2 weeks. Results The progress of weight loss was steady in the first 4 weeks except for the sixth weight check. After 4 weeks treatment, the weight loss was 3.52±1.98Kg and 4.83±2.68%. Total fat mass measured by BIA significantly decreased 2.58±1.30Kg after 4 weeks. Age and the weight loss were significantly negative correlated. Conclusions Oriental obesity treatment could be effective on obesity, but further studies would be needed for the foundation of a clinical guideline reflecting various factors.
  • 7.

    A Comparative Study on Effects of Kyungohkgo and Kyungohkgo Ga Nokyong on Growth in Growth Deficiency Rat with Insufficient Nutrition Diet

    Cha Yun Yeop | 2009, 9(1) | pp.59~69 | number of Cited : 2
    Abstract
    Objectives This study was designed to evaluate the difference of between Kyungohkgo and Kyungohkgo Ga Nokyong effects on growth. Methods We divided male Sprague-Dawley rats into 6 groups. They were Normal group, Growth deficiency rat with insufficient nutrition diet group, Growth deficiency rat with 0.1% Kyungohkgo group, Growth deficiency rat with 0.2% Kyungohkgo group, Growth deficiency rat with 0.1% Kyungohkgo Ga Nokyong group and Growth deficiency rat with 0.2% Kyungohkgo Ga Nokyong group. They were administered for 5 weeks. We measured body weight, serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, RBC, concentration of Hb and PCV ratio, total WBC and its composition, the values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities. Results 1. In body weight, Kyungohkgo 0.1%, Kyungohkgo Ga Nokyong 0.1%, 0.2% groups were showed significantly different than control group. But That groups were not showed significantly different than each others. 2. In serum growth hormone, insulin- like growth factor and thyroid stimulating hormone, we obtained the results of tendency to increase in Kyungohkgo Ga Nokyong group, however these values showed no significantly different. 3. In the counts of RBC, Kyungohkgo group and Kyungohkgo Ga Nokyong group were showed significantly different than control group. But these values showed no significantly different. In the concentration of Hb, Kyungohkgo Ga Nokyong 0.2% group was showed significantly different than control group. Kyungohkgo Ga Nokyong 0.2% group and Kyungohkgo 0.2% group were showed significantly different than control group. 4. The counts of total WBC and its composition showed no significantly different in all treatment groups. 5. The values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities showed no significantly different in all treatment groups. Conclusions So Kyungohkgo Ga Nokyong and Kyungohkgo have an effect of promoting growth of rats. And We know that the effect of Kyungohkgo Ga Nokyong is better than Kyungohkgo.
  • 8.

    A Study on the Acute Toxicity of Bangpungtongsung-san(Fangfengtongsheng-San) in Mice

    이재훈 | Ki-suck Shim | Hwayong Park and 3other persons | 2009, 9(1) | pp.71~78 | number of Cited : 10
    Abstract
    Objectives Bangpungtongsung-san(Fangfengtongsheng-san) has been traditionally prescribed a a restorative medicine. Methods In this study, we investigated the acute toxicity of water-extracted Bangpungtongsung-san(Fangfengtongsheng-san). 20 male and 20 female mice were orally treated of Bangpungtongsung-san(Fangfengtongsheng-san) at the respective doses of 0 (control group), 1250, 2500 and 5000mg/kg for 14 days. Results We observed survival rates, general toxicity, change of body weight and examined microscopic changes of some organs. Conclusions Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000mg/kg). LD50 of Bangpungtongsung-san(Fangfengtongsheng-san) might be over 5000mg/kg and it was very safe to ICR mice.
  • 9.

    A Case Study on A Patient with Non-alcoholic Fatty Liver Disease(NAFLD) Improved on Sonography by Oriental Obesity Therapy

    Kyoung-Sun Park | 조정훈 | 이창훈 and 2other persons | 2009, 9(1) | pp.79~86 | number of Cited : 3
    Abstract
    Objectives The purpose of this study was to investigate the clinical effect of oriental obesity therapy on obese patient with non-alcoholic fatty liver disease(NAFLD). Methods The patient was treated from November 17, 2008 to May 15, 2009 for obesity treatment. And the patient had intensive care through admission treatment from November 17, 2008 to November 29, 2008. Electrolipolysis, auricular acupuncture, herbal medicine, low calorie diet and aerobic exercise were done during the treatment period. Results His body weight decreased from 102.8kg to 82.7kg. The BMI decreased from 35.2kg/m2 to 28.9kg/m2. NAFLD effectively improved on sonography from grade Ⅱ~Ⅲ to grade Ⅰ~Ⅱ after oriental obesity therapy. AST decreased from 65 to 19. ALT decreased from 152 to 18. Oriental obesity therapy could be effective to treat obese patient with NAFLD. Conclusions The obese patient with NAFLD improved on sonography by oriental obesity therapy.