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pISSN : 1976-9334 / eISSN : 2288-1522

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2014, Vol.14, No.1

  • 1.

    Analytical Study on Medical Leech in the Last 10 Years: A Suggestion of Practical Use on Obesity and Metabolic Syndrome

    이진원 , 박원형 , Cha Yun Yeop and 1 other persons | 2014, 14(1) | pp.1~12 | number of Cited : 2
    Objectives: The purpose of this study is to analyse research trends about medical leech in the last10 years. Methods: We searched the papers with key words of ‘medical leech’, ‘水蛭’ in China KnowledgeResource Integrated Database (CNKI), Korean traditional knowledge portal, DBPIA, KISS. Weclassified the papers by year and content. Results: 1. Result of the classification on the basis of the research methods, 50 studies are clinicalcase reports, 301 studies are experimental paper, 599 studies are clinical trial study, 219 studiesare literature review. 2. Result of the classification on the basis of the research topics, 454 studiesare the effect of anticoagulant research, 84 studies are diabetes and renal disease research, 194studies are pharmacological properties research, and 43 studies are effect of allergic andanti-inflammatory research. 3. The proportion of the coagulation effect study tends to decreaseevery year since 2006. 4. Leech research tends to decrease in last 3 years. 5. Recently, there aremany research in psychiatry, orthopedic diseases and beauty. 6. There are 10 studies related toleech in Korean. Conclusions: The researches of medical leech are actively done. The diversity of subjects isgetting wider and richer.
  • 2.

    Screening of Herbal Medicines for Synergistic Effects of Metformin and Herbal Extracts Combination in RAW 264.7 Cells

    김형구 , Jing-Hua Wang , 채희성 and 3 other persons | 2014, 14(1) | pp.13~23 | number of Cited : 2
    Objectives: This study was performed to evaluate the effects of Metformin and Lonicerae Flos,Agrobacterium Rhizogenes, Coptidis Rhizoma, Atractylodis Rhizoma Alba, Houttuyniae Herbaextracs combinations on hypoglycemia in RAW 264.7 cells. Methods: Expressions of Sirt1, p-adenosine monophosphate-activated kinase (p-AMPK), AMPKalpha,peroxisome proliferator activated receptor (PPAR)-alpha, PPAR-gamma, X-box bindingprotein 1 (XBP-1), tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 were analyzed by realtime polymerase chain reaction and Western blotting analysis. Results: The level of gene expression of Sirt1, p-AMPK, AMPK-alpha, PPAR-alpha and XBP-1 inrelation to that of beta-actin were increased or decreased significantly with the Metformin andLonicerae Flos, Agrobacterium Rhizogenes extracts combination groups. The level of geneexpression of TNF-alpha and IL-6 were increased significantly with the Metformin andHouttuyniae Herba, Coptidis Rhizoma extracts combination groups. Conclusions: Metformin and Lonicerae Flos, Agrobacterium Rhizogenes extracts combinationgroups showed synergistic hypoglycemic effects by increasing AMPK and PPAR gene expressionin RAW 264.7 cells
  • 3.

    Relation between Obesity Pattern Identification and Metabolic Parameters in Overweight and Obese Women

    송미영 , Myeong-Jong Lee , Hojun Kim | 2014, 14(1) | pp.24~28 | number of Cited : 3
    Objectives: We conducted this study to analysis obesity pattern and obesity related bloodparameters. Methods: A total of 64 overweight and obese (body mass index [BMI] ≥23 cm/kg2) women whohad no other disease was recruited. Body composition and obesity related blood parameters weremeasured. Also subjects were given and filled out the Obesity pattern identification questionnaire. We analyzed the differences of body composition and blood parameters and measuredcorrelations of BMI and blood parameters in each obesity pattern. Results: The distribution of obesity pattern was liver depression (35.6%), food accumulation(47.5%) and deficiency (pi and yang deficiency, 22.0%), in order. There were no significantdifferences age, body composition and obesity related blood parameters between obesitypatterns. BMI and obesity related blood parameters, however, showed significant correlationsdepending on obesity patterns. Conclusions: We concluded that correlations between BMI and obesity related blood parameterswere differed depending on obesity patterns.
  • 4.

    How Does Body-Shape Perception Affect the Weight Control Practices?: 2012 Korea National Health and Nutrition Examination Survey

    유정은 , 오달석 , Kim Namkwen | 2014, 14(1) | pp.29~35 | number of Cited : 10
    Objectives: This study was to investigate how body-shape perception could influence to weightcontrol practice both in normal and obese group. Methods: We used 2012 Korea National Health and Nutrition Examination Survey to analysis 1)weight control practices of population; 2) consistency between body-shape perception and bodymass index; 3) comparison weight control practices between normal group and body mass index(BMI) obese group in perceptional obese group; 4) odds ratio of BMI obese group using herbaldrugs for weight control practice in perceptional obese group. Results: We found that study population tends to choose exercise, dietary restriction, meal skip,health functional food, one-food, drug, herbal drug, fasting and self-medication in order offrequency to control weight. The agreement between body-shape perception and BMI withinobese group was approximately 64% with 0.40 of Cohen’s Kappa coefficient, ranging from 0.384to 0.423. Within perceptional obese group, choosing each weight control practice methods ratiosbetween normal BMI group and obese BMI group were not significantly different. Withinperceptional obese group, obese BMI group showed significant odds ratio (2.58, 95% confidenceintervals, 1.38∼4.85) than normal BMI group in choosing herbal medication for weight loss whenadjusting other variables. Conclusions: We concluded that body-shape perception might be an important factor forchoosing weight control program, and roles of Korean medical doctors thought to be enhanced forusing herbal medication for weight loss.
  • 5.

    The Comparisons of Eating-Related Index and Pre- and Post-Prandial Gut Hormone Patterns between Normal-Overweight and Obese Subjects of Taeemin

    이지원 , 박병주 , Jun-Hee Lee | 2014, 14(1) | pp.36~45 | number of Cited : 3
    Objectives: The purpose of this studay was to compare the eating-related index and the patternsof pre- and post-prandial gut hormone level in normal-overweight and obese subjects of Taeeminpopulation. Methods: We enrolled healthy male participants who were diagnosed with Taeeumin by SasangConstitutional diagnosis and who were normal-overweight (18.5 kg/m2≤body mass index[BMI)< 25 kg/m2) or obese (25.0 kg/m2≤BMI<30 kg/m2). Eating behavior and gastrointestinalproblems were assessed by using standardized scale. Subjective appetite ratings using visualanalogue scales and the profiling of serum levels of ghrelin and peptide YY (PYY) were assessedbefore and after a standard meal (6 time points: 30 minutes pre-prandial, immediately beforemeal, 15, 30, 60, and 120 minutes post-prandial). Results: Tewnty two healthy Taeeumin people classified as normal-overweight group or obesegroup are the final subjects. External eating score of Dutch eating behavior questionaire scoresis higher in normal-overweight group than in obese group. The variations of subjective appetiteratings in obese group are smaller than in normal-overweight group. The pattern of ghrelin innormal-overweight group shows a high peak at 30 minutes post-prandial point, which is contraryto existing studies. The pattern of PYY in obese group decreases from 15 minutes post-prandialpoint and shows lower peak level, whereas in normal-overweight group shows increasingtendency from pre-prandial point until 30 minutes post-prandial point. Conclusions: There are differences in the eating-related index and the gut hormone patternsrelated to obesity.