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pISSN : 1976-9334 / eISSN : 2288-1522

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2013, Vol.13, No.1

  • 1.

    An Analysis of Domestic Medicine Study Tendency on Obesity -Focused on The Korean Journal of Obesity-

    김두희 , 신우석 , 김동환 and 4 other persons | 2013, 13(1) | pp.1~9 | number of Cited : 8
    Objectives: This study was performed to analyze the recent trend of the studies about obesity inmedicine and to provide background for futher studies. Methods: All of the article were selected in “The Korean Journal of Obesity”. Search wereconducted through “http://kosso.or.kr” with the search word “obesity”. Collected articles wereclassified into clinical study, experimental study, literary study, case report. Results: One hundred eighty four studies were included and analyzed in terms of study design,subject, intervention, period, obesity index and so on. The numbers of clinical studies, literarystudies, experimental studies, case reports were respectively 143 (77.7%), 26 (14.1%), 2 (1.1%)and 7 (3.8%). In clinical studies, observational studies were 112 (78.3%) and intervention studieswere 31 (21.7%). And most of sample sizes were more than 100 and less than 499. Body massindex, waist circumstance, body fat percent were major criteria of clinical study. Most of thesubjects on obesity were about relation with another disease or experimental results anddiagnosis. According to classification by the kinds of intervention, diet, exercise, drug, behaviorwere respectively 22, 18, 8, and 8. More than fourty percent of intervention studies were studiedfor 12 weeks. Conclusions: To improve the quality of Korean Medicine study for obesity, we need to recruitingbig sample size and activate randomized clinical trial.
  • 2.

    Study of Korean Medicine’s Pathological Symptoms and Health-Related Quality of Life among Normal, Overweight, and Obese Groups from Multi-Center Case Report

    JAECHUL LEE , 동상옥 , Si-Woo Lee | 2013, 13(1) | pp.10~16 | number of Cited : 2
    Objectives: This work aimed to investigate differentiations of Korean medicine’s pathologicalsymptoms and SF-12 sub scales among normal, overweight and obese subjects from multi-centercase report. Methods: From 2009 to 2011 survey were carried out to 1,589 subjects who took treatment orwere hospitalized in 7 Korean medicine hospitals and 3 Korean medicine clinic. Survey includeKorean medicine’s pathological symptoms and SF-12. Whole survey were obtained from subjectswith interviewers. Obesity degree was divided into three groups by body mass index: Normalgroup is from 18.5 below 23, overweight from 23 below 25 and obese group is over 25. Chi-squaretest was performed to reveal differentiation response rate of pathologic symptoms among obesitygroups. ANOVA test was carried out for compare each group’s SF-12 sub scales. Results: Patients of overweight or obesity have more symptoms such as skin itching, swelling,weakness in lower legs, and feverish with swollen joints. Contrary, normal weight groupresponded symptoms of dry skin more than those of obese group. As a fatigue, obese group havemore fatigue feeling at afternoon and evening, compared to high frequency response of normalweight groups’ morning fatigue. Obese groups shows low physical scores of health related qualityof life, in contrast, high mental scores of that. Conclusions: This is first work of pathologic symptoms shown by obese groups. This wouldcontribute to standardization of Korean medicine’s pattern identification as suggestion ofclassification point for obese groups.
  • 3.

    Anti-Obesity Effects of Fermented Samjung-hwan in High Fat Diet Rats

    송미영 , Shambhunath Bose , Hojun Kim | 2013, 13(1) | pp.17~23 | number of Cited : 12
    Objectives: This study was performed to evaluate the effects of fermented Samjung-hwan (SJH)extracts on weight, serum lipids and blood glucose. Methods: SJH was fermented using three different probiotic bacterial strains (Lactobacillusplantarum [LP], Leuconostoc mesenteroides [LM], Bifidobacterium longum [BL]) separately. Thirty-six rats were divided into normal, control (high fat diet), SJH-UF (high fatdiet+unfermented SJH 200 mg/kg), SJH-LP (high fat diet+LP fermented SJH 200 mg/kg),SJH-LM (high fat diet+LM fermented SJH 200 mg/kg) and SJH-BL (high fat diet+BLfermented SJH 200 mg/kg). For 8 weeks later, we examined body weight, total cholesterol,high-density lipoprotein (HDL)-cholesterol and blood glucose. Results: The control group showed significantly increased weight gain compared with normalgroup and SJH-LP and BL groups had less weight gain than control group, significantly. In the lipidserum tests, control group showed significantly increased total cholesterol levels compared withnormal group and only SJH-LP represented decreased total cholesterol levels compared withcontrol group. However there was no significant change in the HDL-cholesteol levels. In the bloodglucose tests, that of control group significantly incereased more than that of normal group, SJH-BL showed significantly decreased blood glucose levels compared with control group. Conclusions: SJH-LP,SJH-BL showed weight control effect, SJH-LP decreased TC and SJH-BL reduced blood glucose.
  • 4.

    Effect of Unfermented and Fermented Atractylodes macrocephalae on Gut Permeability and Lipopolysaccharide-Induced Inflammation

    한경선 , 김기철 , Jing-Hua Wang and 1 other persons | 2013, 13(1) | pp.24~32 | number of Cited : 8
    Objectives: The aim of this study is to investigate anti-imflammatory and protective effect forintestinal epithelial cells with Atractylodes macrocephae (AM), a traditional Korean Herbalmedicine and fermented Atractylodes macrocephae (FAM) with Lactobacillus plantarum. Methods: HCT-116 and Raw 264.7 cells were used in this study. Using NO assay, we measuredlipopolysaccharide (LPS)-induced anti-inflammatory effect. We measured permeability ofintestinal epithelial cells with transepithelial electrical resistance and horseradish peroxide fluxassay. Water soluble tetrazolium salt assay was used to see cell proliferation. All the results werepresented in mean and standard deviation. We used Student's t-test for analyzing significance ofresults. Results: In Raw 264.7 cells NO production decreased 22.4% with pre-treatment of AM and FAM,especially with FAM in high concentration. In HCT-116 cells LPS-induced intestinal permeabilityhad a protective effect with both AM and FAM, which was also tend to be proportional to theconcentration. Cell viability increased up to 135.52% after treatment of high concentration ofFAM in HCT-116, while there was no significant change in Raw 264.7 cells with herb treatments. Conclusions: These results show evidence that AM, especially fermented ones, significantly reduced intestinal membrance permeability. They also had a protective effect as well as an anti-inflammation effect for HCT-116 and Raw 264.7 cells. This suggest that FAM may be a therapeutic agent for Leaky gut syndrome by reducing intestinal permeability.
  • 5.

    Study on the Characteristics of Ordinary Symptoms in Overweight and Obesity Patients according to Sasang Constitution

    신승원 , Jun-Hee Lee | 2013, 13(1) | pp.33~45 | number of Cited : 10
    Objectives: This study was aimed to find out the characteristics of ordinary symptoms betweenthe control and patient groups, diagnosed as overweight or obesity, in Soyang, Taeeum, andSoeum Constitutions and among those 3 groups. Methods: As a prospective cross-sectional study based on medical records, 9213 patients, whovisited Kyung Hee University Medical Center from May in 2007 to June in 2010, were included. To diagnose the constitution, Revised Questionnaire for the Sasang Constitution Classification II and examinations by oriental medical doctors who majored in Sasang Constitution Medicinewere performed. Based on the World Health Organization criteria for Asian obesity assessment,body mass index (BMI) was classified into 3 groups; more than 25 as obesity, 23 to 25 asoverweight, and less than 23 as normal. Ordinary symptoms questionnaire, which consists of 46questions in 8 categories, were given to the subjects. One-way ANOVA test in continuousvariables and chi-square test in categorical variables were carried out to analyze statisticalsignificance. Results and Conclusions: 1) In general characteristics, we could find out the significantdifferences in age, sex, height, weight, BMI, waist circumference, blood pressure, total cholesterol,triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol,fasting blood sugar, and hemoglobin A1c among the 3 Constitutional groups. 2) SoyangConstitution of overweight and obesity has tendency to have higher appetite, like cool or coldwater, defecate more, swear more, dislike heat, and have warmer or hotter extremities in theordinary symptoms, compared with the control group. 3) Taeeum Constitution of overweight andobesity has tendency to have higher appetite, like cool or cold water, defecate more, swear more,dislike heat, and have warmer or hotter extremities in the ordinary symptoms, compared with thecontrol group. 4) Soeum Constitution of overweight and obesity has tendency to have higherappetite and less fatigue in the ordinary symptoms, compared with the control group. 5) SoeumConstitution showed the slightest increase in appetite, preference about room temperaturewater, less number of feces, and feeling of chill and warmer extremities in ordinary symptoms,compared with Soyang and Taeeum Constitutions. Taeeum Constitution showed the distinctincrease in appetite and sweating in ordinary symptoms, compared with Soyang and SoeumConstitutions.
  • 6.

    A Case Series: The Effects of Cultivated Wild Ginseng Pharmacopuncture and Thread Implantation Therapy on Abdominal Obesity

    Misook Shin | 2013, 13(1) | pp.46~50 | number of Cited : 11
    This study was to investigate the effects of cultivated wild ginseng pharmacopuncture and threadimplantation therapy on abdominal obesity. These 5 subjects were selected among the patientswho were 30 to 38 years old. We practiced combined therapy such as cultivated wild ginsengpharmacopuncture on 5 points of abdominal fat and thread implantation therapy on 10 points ofabdominal fat, twice a week, totally for 2 weeks. And the other therapies and recommendationsabout nutrition and exercises were totally excluded for 2 weeks. Body weight was reduced by 1.0kg. Fat mass was reduced by 1.36 kg. And waist circumference was reduced by 3.98 cm. Thus itwas acknowledged that waist partial fat could be reduced only by 2 interventions within 2 weeks. It could be more effective than any other combined therapy program including 10 therapymethods of oriental medicine.