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pISSN : 1976-9334 / eISSN : 2288-1522

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2015, Vol.15, No.1

  • 1.

    The Effects of Electroacupuncture for Treatment of Patients with Non-Alcoholic Fatty Liver Disease: Prospective Randomized Controlled Study

    Lee, Changhyeong , Byungseok Kim , 최애련 and 3 other persons | 2015, 15(1) | pp.1~8 | number of Cited : 3
    Objectives: The aim of this study was to evaluate the effectiveness and safety of electroacupuncture for non-alcoholic fatty liver disease (NAFLD). Methods: A randomized, controlled pilot trial was conducted. Twenty-two participants were randomized into one of the two groups: an acupuncture group (n=11) and wait-list group (n=11). The treatment group received 8 sessions of electroacupuncture over 8 weeks. Twenty points (CV4, CV12, both LR14, GB26, ST25, ST34, ST40, ST36, SP4, SP6, LR3) were selected for needling. The control group did not receive acupuncture treatment during study period and follow- up were done in the 4th and 8th weeks after randomization in both groups. The primary outcome was body fat computed tomography and the secondary outcomes included blood test (aspartate aminotransferase, alanine transferase, triglyceride, total cholesterol, high density lipoprotein- cholesterol, low density lipoprotein-cholesterol, blood sugar test, g-guanosine triphosphate) and body composition test (body mass index, weight, body fat mass, body fat rate, waist hip ratio). Safety was assessed at every visit. Results: There was no significant differences in between the experimental group and control group. There were no adverse events. Conclusions: The results suggest that In patients with NAFLD, electroacupuncture treatment did not induce worsening of liver disease and liver function, but it was no improvement symptoms of fatty liver. Study of herb medicine treatments and other acupuncture therapy of NAFLD are required later.
  • 2.

    Comparison of Gangji-hwan-1, 2, 3, 4 and Combination of Gangji-hwan-1 and Gamisoche-hwan in the Reducing Effects of Body Weight in a High Fat Diet-Fed Obese Mice

    Jae Sang Yoo , Ja Ryong Ku , Ki Hyeon Yoon and 9 other persons | 2015, 15(1) | pp.9~23 | number of Cited : 5
    Objectives: This study was investigated the improvement effects of Pakistani Ephedra herba- containing Gangji-hwan-1, 2, 3 (Di-fatty; DF-1, 2, 3), Chinese Ephedra herba-containing Gangji- hwan-4 (DF-4) and combination of DF-1 and Gamisoche-hwan (GSH) on obesity in a high fat diet-fed obese mouse model.Methods: Eight-week-old C57BL/6N mice were divided into seven groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-1, 2, 3, 4, and DF-1+GSH groups given a high fat diet with DF-1, 2, 3, 4 (40, 80, 160, 80 mg/kg), and DF-1+ GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio (FER), blood lipid markers, liver histology, and fat weight and histology were examined.Results: Body weight gain was significantly decreased in DF and DF-1+GSH groups compared with control. The extent of decreases was eminent in DF-1+GSH group. FER and circulating concentration of leptin were decreased in DF and DF-1+GSH groups compared with control. Circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF-1+GSH groups compared with control. The size of adipocytes were decreased by DF and DF-1+GSH groups compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF-1+GSH groups decreased the number of large adipocytes.Conclusions: In conclusion, these results suggest that DF and DF-1+GSH groups decrease FER, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain. In addition, these effects were more effective in DF-1+GSH combination group than in DF-1, 2, 3, 4 groups.
  • 3.

    Effect of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes and Coptidis Rhizoma Extracts Combined with Metformin on the Antioxidant and Adipocyte Differentiate Inhibition

    장세주 , 한경선 , Jing-Hua Wang and 5 other persons | 2015, 15(1) | pp.24~32 | number of Cited : 6
    Objectives: This study was to investigate the antioxiative capacity, antiobesity effects of Atractylodes Rhizoma Alba, Houttuyniae Herba, Lonicerae Flos, Agrobacterium Rhizogenes, and Coptidis Rhizoma on Raw 264.7 and 3T3-L1 cell lines.Methods: Three different types of herb extracts (A. Rhizoma Alba, H. Herba, L. Flos, A. Rhizogenes, and C. Rhizoma; water 100%, ethanol 30%, ethanol 100%) were used in this study. Total polyphenol compound, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, reactive oxygen species (ROS) activity, NO production and cell proliferation were measured.Results: Total polyphenol compound measurement of L. Flos, A. Rhizogenes, and C. Rhizoma extracts were higher than A. Rhizoma Alba, H. Herba. DPPH radical scavenging activity, ROS activity and NO production of A. Rhizogenes, C. Rhizoma extracts were lower than L. Flos, A. Rhizoma, and H. Herba.Conclusions: Metformin and A. Rhizogenes, C. Rhizoma, A. Rhizoma Alba, and L. Flos extracts combination groups showed synergistic effect on adipocyte differentiation inhibition and antioxidative activity.
  • 4.

    Retrospective Study about the Effectiveness of Korean Medicine Treatment on 254 Patients Visited Obesity Clinic

    이용호 , 고남경 , 민들레 | 2015, 15(1) | pp.33~37 | number of Cited : 4
    Objectives: The purpose of this study is to report the effectiveness of Korean medicine treatment on 254 patients visited obesity clinic.Methods: Two hundred fifty-four patients, who had visited obesity clinic from May 2013 to November 2014, were analyzed by bioelectrical impedance analysis. We analyzed changes of weight, skeletal muscle mass, fat mass, body mass index (BMI) and body fat percentage after treatment, also investigated differences of weight and fat mass loss according to age, BMI and body fat percentage.Results and Conclusions: Male and female percent of the study group was 3.5% and 96.5%. All patients were constituted with 50.0% of 20∼29-year-old group, 34.1% of 30∼39-year-old and 15.9% of 40 and more year-old. In BMI, 21kg/m2, 21.0∼22.9 kg/m2, 23.0∼29.9 kg/m2, above 30 kg/m2 were 20.5%, 30.3%, 42.1%, 7.1%, respectively. In Body fat percentage, under 25%, 25.0%∼29.9%, 30.0%∼34.9%, above 35% were 11.4%, 23.2%, 30.7%, 34.6%, respectively. 96.1% of patients were showed weight loss compared with baseline, the decrease of body weight was 2.96±1.86 kg, that of BMI was 1.13±0.70 kg/m2 and that of body fat percentage was 2.43%±2.06% after 1 month treatment. We observed a decline of weight and fat mass with higher BMI and body fat percentage at the baseline.
  • 5.

    Effect of Root of Atractylodes macrocephala Koidzumi on Myogenesis in C2C12 Cells

    송미영 | 2015, 15(1) | pp.38~44 | number of Cited : 5
    Objective: Skeletal muscle is a crucial tissue from the perspectives of mitochondrial dysfunction and insulin resistance, it is formed by myogenesis which is dynamic multistep process to be myotubes. The authors could found that root of Atractylodes macrocephala Koidzumi (Atractylodis Rhizoma Alba, ARA) enhanced glucose and lipid metabolism in C2C12 myotubes via mitochondrial regulation. However its action in myogenesis process is not known. The aim of this work was the study of ARA on proliferation, differentiation and hypertrophy in C2C12 cells. Methods: To study proliferation phase, cells were incubated in growth medium with or without ARA (0.2 or 1.0 mg/ml) for 24 hours. To examine differentiation, at 70% confluence, cells were transferred in differentiation medium both with/without ARA (0.2 or 1.0 mg/ml) for 96 hours. And after 72 hours of differentiation, cells were treated with or without ARA (0.2 or 1.0 mg/ml) for 24 hours, the genesis of hypertrophy in myotubes were analyzed. Results: In proliferation phase, ARA could make difference in morphologic examination. In differentiation phase, it also made morphologic difference furthermore ARA (1.0 mg/ml) increased mRNA expressions of Myogenic regulatory factors and muscle-specific proteins synthesis. In late differentiation, ARA induced hypertrophic morphological changes in neo-formed myotubes. Conclusions: ARA might control cell cycle promoting myogenesis and hypertrophy in C2C12 cells.
  • 6.

    A Case Report for an Eating Disorders with Banhabaeckchulchunma-tang and Acupuncture Treatment

    정동훈 , 신우석 , 박원형 and 2 other persons | 2015, 15(1) | pp.45~50 | number of Cited : 4
    Eating disorders is a significant failure on the dietary behavior, can be distinguished by anorexia nervosa and bulimia nervosa. For the treatment of eating disorders, screening for medical conditions and hospitalizations are needed. Also, medications such as antidepressants may be helpful, and it should be considered a dynamic psychotherapy, cognitive behavioral therapy, and family therapy together. Recently we experienced a 24-year-old woman who was accompanied with binge eating at night, habitual vomiting, dizziness, anorexia, and general weakness. We applied Banhabaeckchulchunma-tang and acupunture treatment during 2 weeks. Through this program, patient's condition was improved on body mass index and Eating Attitude Test-26.
  • 7.

    Korean Medical Obesity Treatments on Localized Fat in Three Japanese

    고남경 , 이용호 , 민들레 | 2015, 15(1) | pp.51~54 | number of Cited : 4
    The aim of this study is to report clinical progresses on localized fat in three Japanese with Korean medicine. We conducted electro-acupuncture on thigh and/or Gamitaeyeumjowi-tang, all subjects had loss of thigh circumference and 2 subjects who took Gamitaeyeumjowi-tang had body weight loss. It shows that Korean medical treatments may be effective on localized obesity and can also apply to Japanese.