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pISSN : 1976-9334 / eISSN : 2288-1522

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2019, Vol.19, No.1

  • 1.

    The Protective Effect of Ethanol Extract of Polygalae Radix against Oxidative Stress-Induced DNA Damage and Apoptosis in Chang Liver Cells

    Hong Yun Kim , Cheol Park , Yung Hyun Choi and 1 other persons | 2019, 19(1) | pp.1~11 | number of Cited : 1
    Objectives: The purpose of the present study was to evaluate the preventive effects of ethanol extract of Polygalae radix (EEPR) against oxidative stress (hydrogen peroxide, H2O2)-induced DNA damage and apoptosis in Chang liver cells. Methods: Chang liver cells were pretreated with various concentrations of EEPR and then challenged with 0.5 mM H2O2. The cell viability and apoptosis were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry analysis, respectively. The levels of reactive oxygen species (ROS), mitochondrial membrane potentials (MMPs) and adenosine tri-phosphate (ATP) contents were measured. Expression levels of Bcl-2 and Bax were also determined using Western blot analysis. Results: The results showed that the decreased survival rate induced by H2O2 could be attributed to the induction of DNA damage and apoptosis accompanied by the increased production of ROS, which was remarkably protected by EEPR. In addition, the loss of H2O2-induced MMPs and ATP contents was significantly attenuated in the presence of EEPR. The inhibitory effect of EEPR on H2O2-induced apoptosis was associated with up-regulation of Bcl-2 and down-regulation of Bax, thus reducing the Bax/Bcl-2 ratio. Conclusions: Our data prove that EEPR protects Chang liver cells against H2O2-induced DNA damage and apoptosis by scavenging ROS and thus suppressing the mitochondrial-dependent apoptosis pathway.
  • 2.

    Research Trend Analysis of Questionnaires for Evaluation of Weight Loss Effect on Health-Related Quality of Life

    Eun-Young Noh , Seo-Young Kim , Young-Woo Lim and 1 other persons | 2019, 19(1) | pp.12~23 | number of Cited : 1
    Objectives: Obesity is associated with a high mortality risk and impairment in health-related quality of life (HRQOL). The aim of this article is to examine the impact of weight loss on HRQOL and which questionnaires sensitively reflect weight loss effects on HRQOL. Methods: PubMed, Scopus, Research Information Sharing Service, and Korean Studies Information Service System were searched for the studies related to weight loss and HRQOL, published from 2009 to 2018. A total of 28 studies were eligible for inclusion. HRQOL results after weight loss from selected studies were classified and reported according to questionnaires. Results: Twenty-two studies reported statistically significant HRQOL improvements after weight loss and especially, all of studies with weight loss of more than 5% reported HRQOL improvements. HRQOL questionnaires were classified as generic, obesity-related and depression questionnaires. The most commonly used questionnaires were Short-Form health survey 36 (SF-36), Impact of Weight on Quality Life-Lite (IWQOL-Lite) and Beck Depression Inventory (BDI) respectively. SF-36 had a tendency to reflect physical health. IWQOL-Lite score was tended to be changed sensitively according to weight change. Depression questionnaires including BDI reported improvement of depression while mental aspects of SF-36 not changed in same studies. Conclusions: Improvements of HRQOL were noted in studies with weight loss of more than 5%. The main questionnaires for evaluating HRQOL were SF-36, IWQOL-Lite and BDI. It is suggested to use these questionnaires together for evaluating multiple aspects of impact of weight loss on HRQOL.
  • 3.

    Eating Self-Efficacy: Development of a Korean Version of the Weight Efficacy Life-Style Questionnaire — A Cross-Cultural Translation and Face-Validity Study

    Hee-Yon Seo , Ji-Myung Ok , Seo-Young Kim and 2 other persons | 2019, 19(1) | pp.24~30 | number of Cited : 1
    Objectives: Eating self-efficacy is an important predictor of successful weight control behaviors during obesity treatment. The Weight Efficacy Life-Style Questionnaire (WEL) is an internationally used measure of eating self-efficacy. The objective of this study was to develop the Korean version of WEL (K-WEL) and verify face validity. Methods: According to previously published guidelines, the cross-cultural translation was conducted through organizing the expert committee, translation, back-translation, synthesis, grammar review, and final synthesis. Following the translation of the WEL into Korean, face validity was performed for 35 subjects. Results: After all the versions of the questionnaire were examined, the translated WEL questionnaires were finally synthesized and licensed by the developer in writing. Regarding the translated WEL questionnaires, seven out of 35 subjects (20%) offered ideas about ambiguous expressions in them. All four points indicated in the face validity verification were additionally modified for greater clarity and understanding. Conclusions: We developed the Korean version of WEL and completed face validity. In future research, it would be necessary to provide further study on the reliability and validity of the Korean version of WEL.
  • 4.

    Analysis of Factors Influencing Obesity Treatment according to Initial Condition and Compliance with Medication

    Ji-Yeon Han , Park Young-Jae | 2019, 19(1) | pp.31~41 | number of Cited : 2
    Objectives: The purpose of this study was to investigate the effects of gender, age, body weight, muscle mass, fat mass, body mass index (BMI), metabolism, and compliance with medication on weight loss in obese adults. Methods: We reviewed the medical records of 178 patients who were visited to the Korean Oriental Clinic for 3~6 month and had obesity treatment using Gamitaeumjowee-tang from April 2017 to May 2017. We conducted a paired T-test, correlation coefficient and decision tree to analyze factors influencing obesity treatment. Results: The results of correlation analysis showed that initial weight (kg), initial fat mass (kg), BMI (kg/m2), compliance with medication (%), Original Harris-Benedict Equation, Revised Harris-Benedict Equation and The Mifflin St Jeor Equation was significantly correlated to weight loss (kg) (P<0.001). As a result of constructing the decision tree model, it showed that over 5% weight loss of their initial weight (n=154) was related with initial BMI (kg/m2), compliance with medication (%) and initial muscle mass (kg). In case of over 5 kg weight loss of their initial weight (n=131), it was related with initial BMI (kg/m2), compliance with medication (%) and final BMI (kg/m2). Conclusions: This study suggests that weight loss may be affected by initial factors and that initial factors can be used for obesity treatment.
  • 5.

    Review on Acceptability of Patients towards Obesity Treatment Program

    Eom-Jee Lee , Seo-Young Kim , Young-Woo Lim and 1 other persons | 2019, 19(1) | pp.42~55 | number of Cited : 1
    Objectives: Acceptability of patients towards obesity treatment program is associated with better weight loss outcomes. The purpose of this study was to review previously published study results of the predictive factors associated with patients’ acceptability in obesity treatment. Methods: Authors searched for the articles related to acceptability reported as continuation, attendance and adherence, published from 2011 to 2018 found on Pubmed, Scopus, Research Information Sharing Service, and Koreanstudies Information Service System. A total of 23 articles were finally selected. From the study results, unchangeable and changeable predictors were extracted, and these predictors were examined according to detail categories. Results: Regarding the continuation of the treatment, unchangeable factors such as younger age, lower educational level, male sexuality and lower accessibility to physical activity predicted lower continuation. Furthermore, changeable factors such as early and half weight loss, better accessibility to the treatment and financial incentives for retention predicted higher continuation rate. Greater degree of attendance was predicted by unchangeable factors such as economical affordability, and changeable predictors such as half weight loss and proximity to the clinic. Main factors of adherence to the recommendation were unchangeable predictors such as weight loss experience, and changeable predictors such as more physical activity and appropriate dietary habits. Negative psychological state predicted lower continuation, attendance and adherence rate. Conclusions: Our review results suggest that unchangeable and changeable predictors of acceptability of patients should be carefully examined during treatments of obesity.
  • 6.

    The Systematic Review on Clinical Studies of Traditional Korean Medicine Treatment for Obesity in Menopausal Women

    Eun-Young Nam | 2019, 19(1) | pp.56~67 | number of Cited : 4
    Objectives: The purpose of this study is to review clinical studies of herb medicine and acupuncture treatment on obesity in menopausal women. Methods: Key words "Obesity", "Menopause", "Herb medicine", "Acupuncture", "Moxibustion", "Catgut embedding" were searched on 9 database systems (PubMed Central, Cochrane Controlled Register of Trials, Embase, China Academic Journals, Korean Traditional Knowledge Portal, Oriental Medicine Advanced Searching Integrated System, Korean Studies Information Service System, National Digital Science Library, DBpia) on April 30th 2019. Results: 1 case report and 17 clinical trials were collected in accordance with the selection and exclusion criteria. Among the 17 trials, 6 were randomized controlled trials, 1 was controlled clinical trial, and 10 were single-arm trials. The types of intervention were herb medicine, electroacupuncture, acupuncture, auricular acupuncture, warm needle acupuncture, moxibustion, laser acupuncture, and catgut embedding. The study design, study results and method of intervention were analyzed. Conclusions: 1 case report described the effectiveness of pharmacopuncture, 4 trials described the effectiveness of herbal medicine, 2 of electroacupuncture, 1 of laser acupuncture, and 2 of catgut embedding. Among the 17 trials, 2 studies showed that herbal medicine treatment was more effective than no treatment or selective serotonin reuptake inhibitors, and 1 study showed that electroacupuncture was more effective than hormone therapy. All of 18 selected studies reported the effectiveness of weight reduction and abdominal obesity reduction after the traditional Korean medicine treatment for obesity in menopausal women.
  • 7.

    A Study on the Research Trends on Obese People with Disabilities: Focused on Domestic Journal

    JungSik-Park , SONG YUN KYUNG | 2019, 19(1) | pp.68~78 | number of Cited : 3
    Objectives: The purpose of this review is to analyse the trend in papers related to obese people with disabilities. Methods: We reviewed Korean Medicine papers by searching 4 Korean web databases and classified the papers by the year of publishment, the title of journals, the type of study, main treatment, assessment for outcomes. Results: There were 18 studies about the intellectually disabled, which accounted for most of the study. It is expected that intensive research on obesity for the intellectually disabled will be conducted in the future. Also, study on obesity for the disabled will require special attention. Disabled person tend to have a higher obesity rate and secondary diseases due to disabilities can be easily developed. Their health care capabilities are more likely lower than those of the general population. Given these considerations, it would be necessary to study metabolic syndrome in parallel in the study of obesity for the disabled. Disabled person are exposed to obesity more easily than ordinary people, and there is a higher risk of health degradation due to complications from obesity, which requires more attention and research. However, since there is not research in the oriental medical and medical circles on obesity in the disabled, medical approaches and studies on obesity in the disabled are necessary. Conclusions: We expect that more interest and research will be carried out on obesity for the disabled in the Korean medicine to achieve clinical application and to develop treatment protocols for the disabled obesity disease.
  • 8.

    Effects of Combination Therapy with Anti-Obesity Herbal Medicine Including Ephedra Herba and Lorcaserin in Obese Patients: Two Case Reports

    Min-Jee Kim , Choi, Han-Seok , Hojun Kim | 2019, 19(1) | pp.79~87 | number of Cited : 1
    Although there has been many studies about the co-administration of herb formula and western medicine, there is none about obesity. The aim of this study was to report the effects of co-administration of herb formula containing ephedra sinica and lorcaserin on two obese patients for about 2~4 months. During the treatment, we checked body weight and body composition, and collected blood samples to evaluate liver, kidney, thyroid function and lipid profile. This treatment not only decreased body weight but also improved body composition and lipid profile in both patients. There was no hepatic or renal toxicity, nor any serious side effects of treatment. This study demonstrated that co-administration of herb formula containing ephedra sinica and lorcaserin is a safe and effective therapy to lose weight and improve metabolic parameters for obese patients. Further large-scale clinical trials are needed to evaluate the anti-obesity effect of the combination of herbal and western medicines.