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pISSN : 1976-9334 / eISSN : 2288-1522

2020 KCI Impact Factor : 1.63
목적과 범위
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한방비만학회지는 2001년부터 발행되어 현재 20년차에 접어든 중견 학회지입니다. 저희 학회지는 한의학 관련 연구뿐 만 아니라 보건의료, 생약, 영양 등 다양한 접근을 통한 비만 및 대사증후군 관련 연구 결과를 출판하고 있습니다.   한방비만학회지는 연구재단 KCI 등재지로서, 매년 2회(6월 30일과 12월 30일) 발행되며, 온라인 전문 투고 시스템에서 open access 및 full text XML 방식의 열람, 연구 윤리와 관련해서는 crossref 검증을 통해 학회지가 독자 및 동료 연구자들에게 쉽게 다가갈 수 있는 서비스를 제공하기 위해 노력하고 있습니다.
편집위원장
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송윤경 (가천대학교 한의과대학)
인용지수
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  • KCI IF(2년) : 1.63
  • KCI IF(5년) : 1.51
  • 중심성지수(3년) : 0.932
  • 즉시성지수 : 0.0625

최근발행 : 2020, Vol.20, No.2

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  • 고지방식이 유도 비만 마우스에서 창출, 지모, 육계, 목단피 혼합추출물의 항비만 및 항당뇨 효능 연구

    정수민 | 설영현 | 전가윤 외 5명 | 2020, 20(2) | pp.69~77 | 피인용수 : 0
    초록
    Objectives: In this study, we investigated the antiobesity and antidiabetic effects of polyherbal extract, DM2 consisting of Atractylodis Rhizoma, Anemarrhenae Rhizoma, Cinnamomi Cortex, and Moutan Radicles Cortex in high fat diet-induced obesity mice. Methods: DM2 extract was prepared with a hot water. Six-week-old male C57BL/6N mice were fed a high-fat diet (HFD) for 8 weeks and then administrated with DM2 extract (500 mg/kg, p.o.) for 4 weeks. The changes of physiological markers, body weight (BW), food and water intakes, and the levels of fasting blood glucose (FBG) were measured once a week for 4 weeks in mice. The the serum levels of glucose, insulin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (T-CHO), triglyceride, and low density lipoprotein cholesterol in sera were measured in mice using autometic chemical analyzer and enzyme linked immunosorbant assay. We also observed the histological changes of liver and pancreatic tissues with Hematoxylin & Eosin staining. Results: In physiological change, the increases of BW, calorie intake, and FBG in HFD-induced obese mice were significantly decreased after administration of DM2 extract for 4 weeks. The decrease of water intake was significantly increased in DM2 extract-administrated mice. In serological change, the administration of DM2 extract in obesity mice was significantly decreased the serum levels of glucose, insulin, T-CHO, AST, and ALT levels. We also found that DM2 extract inhibited the increase of lipid droplets in liver and the structural destruction of pancreatic tissues in obesity mice. Conclusion: Our study demonstrated that DM2 extract has antiobesity antidiabetic effects with body weight loss, decrease of glucose and insulin levels, and lipid accumulation on liver tissue.
  • 65종 한약처방이 3T3-L1 지방전구세포의 지방 분화에 미치는 효능 비교 연구

    최혜민 | 유병우 | 김민주 외 1명 | 2020, 20(2) | pp.78~87 | 피인용수 : 0
    초록
    Objectives: To expand and provide information on the efficacy of herbal medicines, anti-obesity effects were evaluated. In many studies, plant-derived components with anti-obesity efficacies have been investigated for their potential inhibitory effects on 3T3-L1 preadipocyte cells. The purpose of this study was to investigate the anti-obesity effects of 65 herbal medicine in 3T3-L1 preadipocyte cells. Methods: Preferentially, 3T3-L1 cells were treated with 65 herbal medicines (500 µg/mL) during differentiation for 8 days. Next, 3T3-L1 cells were treated with selected herbal medicines at concentrations ranging from 50 to 200 µg/mL during differentiation for 8 days. The accumulation of lipid droplets was determined by Oil Red O staining. The expressions of genes related to adipogenesis were measured by reverse transcription polymerase chain reaction and Western blot analyses. Results: Among the 65 kinds of herbal medicines, 13 herbal medicines that been shown to be effective against the accumulation of lipid droplets were selected. Finally, selected Banhasasim-tang and Samhwangsasim-tang showed inhibitory activity on adipocyte differentiation at 3T3-L1 preadipocytes without affecting cell toxicity. In addition, Banhasasim-tang and Samhwangsasim-tang significantly reduced the expression levels of several adipocyte marker genes including peroxisome proliferator activated receptor-γ and CCAAT/enhancer binding protein-α. Conclusions : These results suggest that the ability of Banhasasim-tang and Samhwangsasimtang has inhibited overall adipogenesis and lipid accumulation in the 3T3-L1 cells. Banhasasim-tang and Samhwangsasim-tang may be a promising medicine for the treatment of obesity and related metabolic disorders.
  • 纈草根 메탄올 추출물이 고지혈증 유발 생쥐의 지질대사에 미치는 영향

    박선미 | 김영균 | 유선애 외 4명 | 2020, 20(2) | pp.88~96 | 피인용수 : 0
    초록
    Objectives: This study was designed to investigate the effects of Valerianae Radix et Rhizoma Methanol Extract (VRME) on serum lipid levels in a high-fat diet-induced hyperlipidemic mice. Methods: Each 8 C57BL/6 mice were randomly assigned to normal diet group, high-fat diet control group, high-fat diet plus 100 mg/kg/day of VRME group. In order to induce hyperlipidemia, high-fat diets were supplied to control group and VRME group for four weeks. Normal diet group were supplied with general feed for four weeks. After that control group supplied only high-fat diets as feed, VRME group received oral administration of VRME with high-fat diets for three weeks. and normal diet group were supplied with general feed for three weeks. After seven weeks, the changes in the body weight, the plasma levels of total cholesterol, triglyceride, high density lipoprotein-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose in serum were measured. Results: In our results, VRME did not affects weight gain, serum AST and ALT in high-fat diet-induced hyperlipidemic mice. Oral administration of VRME lowered levels of total cholesterol and triglyceride, which were elevated by induction of hyperlipidemia. and oral administration of VRME lowered blood glucose significantly. Conclusions: These results suggest that VRME could act as a potent antihyperlipidemic in therapeutics for hyperlipidemia.