The purpose of this study was to investigate the relationship between self-esteem, quality of life, and depression of nursing students, and to determine the effect on depression. The subjects of the study were 311 nursing students and collected data from November 20 to December 5, 2017. Data analysis was performed using the SPSS 21.0 program, t-test, ANOVA, Pearson correlation and multiple linear regression analysis. As a result, there were significant differences in college life satisfaction among general characteristics. Self-esteem was 3.37, quality of life was 3.54, and depression was 16.52.
Depression was found to have a significant negative correlation with quality of life. The most significant influence on depression was quality of life, and the explanatory power was 48.2%. Based on the results of this study, it is necessary to develop and apply intervention programs to prevent depression of nursing students.