Objectives: This study intended to investigate the effect of Nunchi, self-leadership, and academic self-efficacy on adaptation to college life among dental hygiene college students in a three-year program. By extension, the study seeks to find positive ways necessary for students to adapt to college life. Methods: A survey was conducted from Aug 1 to Sep 30, 2019 on 182 dental hygiene college students who agreed to participate in the survey. Data were analyzed using SPSS 20.0. An independent t-test, a one-way ANOVA, Scheffe’s post-hoc test, and Pearson’s correlation coefficients were employed, and a multiple regression analysis was conducted. Results: Findings showed that the students’ average score on adaptation to college life was 3.34. Factors having a significant effect on adaptation to college life came out in this order: grade_dummy2(2/3), academic self-efficacy and grade_dummy1(1/2). Explanations skills accounted for 28.0%. Conclusions: The results highlight a need for programs dedicated to improving dental hygiene college students’ adaptation to college life should be developed and implemented.