Objectives: This study was conducted to investigate the effect of self-control and interpersonal relationship satisfaction on department satisfaction among dental hygiene students. Methods: A survey was conducted on 306 dental hygiene students from Seoul, Gyeonggi, Chungcheong, Jeolla, and Gyeongsang. Results: The factors affecting college department satisfaction of dental hygiene students were interpersonal relationship satisfaction (β=0.609), volunteer activities_dummy 1 (No/ Yes) (β=0.131), and year_dummy 3 (1/4) (β=0.128). The most deterministic factor was interpersonal relationship satisfaction with the explanatory power of 37%. Conclusions: Based on these results, it is thought that research on department satisfaction needs to be actively conducted to develop adequate measures and programs to enhance department satisfaction of students.