Objectives: This study was aimed at investigating the oral hygiene device use by cardiovascular disease patients and assessing related factors. Methods: We used data of 1,630 cardiovascular disease patients (including hypertension, stroke, and myocardial infarction) from the 7th Korean National Health and Nutrition Examination Survey (2016-2018). The χ² test and logistic regression analysis were performed to analyze the oral hygiene device use by the subjects and assess related factors. All statistical analyses were performed with the IBM SPSS Statistics, version 20.0. Results: The oral hygiene device use and related factors were significantly higher in patients with an educational level of middle school or below high school, with a score of 1.85 (95% confidence interval [CI] = 1.35–2.53), or college, with a score of 1.93 (95% CI = 1.19–3.14), compared to those with an educational level below primary school. Further, the oral hygiene device use and related factors were significantly higher in patients who answered ‘yes’, with a score of 1.96 (95% CI = 1.42– 2.73), compared to those who answered ‘no’ to the question on oral examination. Conclusions: More patients with cardiovascular disease did not use oral hygiene devices than those who did. It is necessary to expand the approach of preventive treatment to increase the utilization rate of oral hygiene devices.