Objectives: In an aging society, the demand for dental medical institutions among the elderly is increasing. There will be an increased demand for high-quality oral health services. Therefore, the purpose of this study was to investigate factors influencing attitudes toward the elderly of Generation Z dental hygiene students. Methods: The participants in this study were 198 dental hygiene students. The survey was conducted from June 1 to 30, 2020, using a structured questionnaire. The questionnaire consisted of knowledge (24 items), attitude (20 items), and experience (11 items) of the elderly. The collection data were compared and analyzed using analysis of variance and multiple regression. Results: Factors influencing attitudes toward the elderly of dental hygiene students appeared positive in those with a lot of experience and higher knowledge of social area, in case of one grade. However, the attitude toward the elderly appears negative in those with a low knowledge of physical area. Conclusions: In order to improve Generation Z dental hygiene students' attitudes towards the elderly, it is necessary to develop a course related to the elderly and a program related to high-quality elderly contact experience opportunities. Socially, it is necessary to promote healthy elderly life through internet broadcasting and YouTube.