Objectives: The purpose of this study was to identify the degree of adaptation of dental hygiene department students to campus life, and to provide basic data to prepare management strategies for effective campus life adaptation. Methods: Three hundred students in the department of dental hygiene in Busan Metropolitan City and Gyeonggi Province were surveyed from October 1 to October 30, 2020 and 291 questionnaires were used in the final data analysis. Results: Better adaptation to campus life was observed in subjects who participated in club activities, possessed an extrovert personality, were well adapted to the dental hygiene department, and had no conflict in interpersonal relationships, thereby showing a significant difference. Regarding the factors affecting the degree of satisfaction with the department, the higher the degree of satisfaction in the major, excellence in major, and coping ability, the higher was the degree of satisfaction with the department. Conclusions: For effective campus life adaptation of the university students as a way to increase the degree of satisfaction with the department, increasing the ability to adapt to campus life through achievement of pride in the major and participation in various interpersonal activities is a possibility. It is necessary to develop a program to create an environment for good adaptation to campus life.