The purposes of this study were 1) to identify and compare the factors affecting dropout consideration between non-distance education and distance education university students, and 2) to suggest practical strategies to prevent university students’ dropout. 350 students attending universities located in Seoul and Gyeonggi Province participated in this research. The survey questionnaire was consisted of 70 items. To analyze collected data, factor analysis was conducted. The results were as follows: First, graduation requirement/teaching evaluation, internal- and/or external support from family and university, instructional design, major effectiveness, and conditions and quality of teaching and learning were identified as the five factors affecting dropout consideration of non-distance education university students. Second, graduation requirement/evaluation, support services from university, instructional design, perceptions of major, and learning activities/content were revealed as the five factors affecting dropout consideration of distance university students. Third, the factors affecting dropout consideration by each group were significantly different. Based on the results, five strategies for preventing university students’ dropout were suggested.