Bilateral profound friendship between China and Pakistan and the "all-weather strategic partnership" have given great support to mutual cooperation. China and Pakistan are moving forward to the goal of "economic corridor construction as the center, Gwadar port, transport infrastructure, energy and industrial cooperation as the points to form the ‘1+4’ economic cooperation and common development". However, the relationship between the two countries is also facing some challenges in the process of sustainable development, among which the populist in Pakistan is gradually emerging. If left unchecked, it may lead to a great threat to CPEC and other cooperation. Therefore, strengthening basic research on populism in Pakistan is of great significance for enhancing the all-weather strategic cooperative partnership and ensuring the smooth implementation of the CPEC. After reviewing the current research status and deficiencies of populism theory, this paper analyzes populism from the dimensions of social classes, religions and regions, so as to deeply understand the breeding source of populism. From the perspective of class, populism in Pakistan has distinct characteristics of class antagonism. From a religious perspective, there is a deeply rooted political psychology among the Pakistani people. From a regional perspective, the traditional social structure of Islam in Pakistan determines that the loyalty of individuals to religion, family and a smaller region is greater than the loyalty to the nation state.