The purpose of this study was to investigate occupational stressors and musculoskeletal pain in occupational therapy practitioners. The questionnaire was distributed to occupational therapists through a convenience sample. A total of 102 responses were received and 93 responses were analyzed except incomplete responses. The statistical analysis was performed using independent t test, one-way ANOVA, and Spearman correlation analysis. In results, the female were significantly higher in wrist pain than the male(p<.05), and clinical experience ≥3 years were significantly higher in job demand than < 3 years, and was significantly lower insufficient job control (p<.05). ≥ Graduate school was significantly lower in insufficient job control and lack of reward than university(p<.05). The rehabilitation hospital was significantly higher in the interpersonal conflict and job insecurity than the university and general hospital(p<.05), and the neck, back, shoulder, and wrist pain were significantly higher in the rehabilitation hospital than the university and general hospital(p<.05). Manual therapy was significantly higher in job stress total score and pain of neck, shoulder, and wrist than the purposeful activity(p<.05). Job stress, neck pain, and shoulder pain were significantly correlated(p<.05). These findings suggest that improvement of environment and system for occupational therapist's job stress reduction and prevention of musculoskeletal pain is needed.