This study examined if gender has any impact on the use of smart media and SNS fatigue of university students while analyzing its effects in moderating the relationship between SNS fatigue and academic procrastination behaviors and learning flow. Data were collected from 267 students from 4-year university located in Seoul and Pusan(male 60.3%), and analyzed by means of t-test and hierarchical regression analyses. The results of the study are following: First, female students spent more time in using smart media than did male students; Second, the frequency of using smart media per day was significantly higher for male students compared to female students. Third, female students were found out to feel more SNS fatigue than male students; Fourth, female students also showed higher score in the variable of academic procrastination behaviors than did male students; Fifth, the moderating effect of gender on academic procrastination behaviors via SNS fatigue was statistically significant, meaning that female students who felt high degree of SNS fatigue were more vulnerable to academic procrastination behaviors than the case of male students. Lastly, however, the moderating effect was not found out in the relationship between SNS fatigue and learning flow. In summary, this study showed the plausibility of female students spending more time on smart media, feeling more SNS fatigue, and finally procrastinating academic work more than did male students. Therefore, this study suggested that gender should be considered at first when higher education institutions plan to provide intervention programs for their students to prevent them from the overuse of smart media and suffering from SNS fatigue.