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pISSN : 2093-4378 / eISSN : 2093-4386

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2011, Vol.18, No.1

  • 1.

    Variations of Neurotrophic Factors and It’s Importances in Spinal Cord Injured Rats and Beagle Dogs

    송인수 | 양준영 | 이준규 and 2other persons | 2011, 18(1) | pp.1~12 | number of Cited : 1
    Study Design : Experimental, prospective study Objectives : To examine the changes in the variable factors after an acute spinal cord injury(SCI) in rats and dogs simultaneously. Summary of Literature Review : No study has examined the variations of several factors in a SCI model in different species. Materials and Methods : In rats, a laminectomy was performed at the T10 level and the injured spinal cord was extracted. In Beagle dogs, the laminectomy level was T10 and T11. The motor function was evaluated using a modified Tarlov’s scale. A RT2 profiler PCR array was used to examine each factor (inflammatory cytokines, factors-related with apoptosis, neurotrophic factors, factors-related with extraceullar matrix). Results : IL-2, TNF, TNFRSF11B increased with time and showed no statistical difference between two species, but TNFSF13B showed a significant difference. BDNF decreased with time in both species, and GDNF was significantly lower in dogs. NGFβ, CTNF and its receptors showed no significant changes in the two species. MMP1 increased in both species but MMP7 decreased in rats and increased in dogs with time, and showed a significant difference between species. Conclusion : The change in inflammatory cytokines and extracellular matrix correlates with each factor in the combined patterns. Moreover, during the first week after SCI, inflammatory cytokines, apoptosis, neutrophic factors, and extracellular matrix factors may show a partial difference between experimental animals, which means that an animal model can be selected according to the particular experimental plan. Key Words : Spinal cord injury, Inflammatory cytokines, Factors-related with apoptosis, Neurotrophic factors, Factors-related with extraceullar matrix
  • 2.

    Effect of the Corrective Osteotomy in Ankylosing Spondylitis to Quality of Life(QOL)

    박예수 | Chang-Hun Lee | 김재훈 and 1other persons | 2011, 18(1) | pp.13~18 | number of Cited : 1
    Study Design: This is retrospective study. Objective: We evaluated the radiologic changes and quality of life after corrective osteotomy in kyphotic deformity of ankylosing spondylitis. Summary of Literature Review: There is few study about that relationship between corrective osteotomy and quality of life. Materials and Methods: Retrospective study about 16 patients who underwent corrective osteotomy from 2005 September to 2007 December was done. Radiologic assessments of sagittal balance were performed on the criteria of thoracic kyphosis, lumbar lordosis, distance between the vertical line on midpoint of C7 and posterosuperior point of S1 pre and postoperatively. Disease specific instruments: the Bath ankylosing spondylitis disease activity index (BASDAI) and the Bath ankylosing spondylitis functional index (BASFI)were applied. Clinical assessments were performed with short form-36 through interview and telephone. Results: The mean thoracic kyphosis was changed from 46.1 degrees to 39.3 degrees. The mean lumbar lordosis was corrected from - 7.4degrees to - 38.4 degrees, and the mean distance between vertical lines of C7 and S1 was improved from 127.1mm to 30mm. There were significant changes in the subgroup of Physical function, Role physical, Vitality, Social function, Role emotional, Mental health. (p<0.05)The changes of BASDAI, BASFI, Bodily pain and General health were not significant. And similar improvements in the radiological results and SF-36 scores were in the 6 patients with Andersson lesion. Conclusion: The parameters of radiographic assessment were improved after corrective osteotomy in the fixed kyphotic deformity of ankylosing spondylitis. General function, social function and mental health were also improved. Key Words: Ankylosing spondylitis, Corrective osteotomy, Quality of life
  • 3.

    Observational Analysis of Korean Society of Spine Surgery Annual Congress: (2001-05) Free Paper: From Presentation to Publication

    김주오 | Byung-Wan Choi | 김주한 and 2other persons | 2011, 18(1) | pp.19~23 | number of Cited : 3
    Study Design: A review of all presentations at the Korean Society of Spine Surgery(KSSS) congress from 2001 to 2005. Objectives: To determine the presentation to publication rate in peer-reviewed journals of abstracts presented at the KSSS congress and evaluate the consistency between the presented abstract and published full-text counterpart. Summary of Literature Review: The rate of publication for presentation at international meetings has been determined but there has been no study for the KSSS. Material and Methods: This study reviewed all podium presentations of the past KSSS Spring and Fall meetings from 2001 to 2005. A computer search for each abstract was performed. The final published journal, time to publication and publication rate were evaluated according to subspecialty. The published full-text article was compared with the original abstract and evaluated for consistency with respect to the author, material and method, and result. Results: A total of 288 free-papers were identified, of which 167 of them were published as full-text articles. The mean time to publication was 12.15 months. The publication rates according to the subspecialty were basic 67%, lumbar 68%, cervical 64%, deformity 50%, trauma 53%, minimal 14% and others 51%, respectively. Conclusion: The presentation to publication rate of the Korean society of spine surgery podium presentations was lower than other international meetings but the articles showed a high consistency rate. Key Word: Korean Society of Spine Surgery congress, Presentation, Publication
  • 4.

    Multiple Bilateral Thoracic Perineural Cysts - A Case Report -

    김명수 | 이창범 | 박형택 and 3other persons | 2011, 18(1) | pp.24~28 | number of Cited : 0
    Study Design: Case report Objectives: We report a case of relatively rare multiple bilateral perineural cysts. Summary of Literature Review: Tarlov cysts, also known as perineural cysts are most often found in the sacral region, but there are a few cases reported in the thoracic region. In particular, there are very few cases of multiple bilateral thoracic perineural cysts. Materials and Methods: A woman aged 65 years with perineural cysts in the bilateral T10-T11 and T11-12 neural foramens, underwent a T10-11-12 decompressive laminectomy and resection of the cyst. Results: Satisfactory results were obtained for the patient after surgery. Conclusions: For more detailed and definitive treatment of thoracic perineural cysts, additional cases are required. Key Words: Thoracic spine, Multiple bilateral perineural cysts
  • 5.

    Cervical Facet Cyst Causing Progressive Paraplegia - A Case Report and Review of Literature –

    Hyoung-Yeon Seo | 정재윤 | 박기헌 and 1other persons | 2011, 18(1) | pp.29~33 | number of Cited : 1
    Study Design: A case report and literature review. Objectives: To report a patient with a cervical facet cyst causing progressive paraplegia, and to review the clinical features, treatment and outcomes of a cervical facetal cyst. Summary of Literature Review: Extradural intraspinal synovial cysts of the cervical spine are quite rare. They typically occur in the cervical region at the C1-C2 junction or in the space adjacent to the facet joints in the lower cervical spine, and show similar clinical features to the intervertebral disc protrusion. Materials and Methods: This article reports a case of a male patient, 64 years old, who presented with a 2 day history of numbness below the nipple and progressive paraplegia. A physical examination at admission revealed a wheelchair ambulatory state due to a motor deficit (motor grade good) below both hip flexors. Magnetic resonance imaging of the cervical spine showed an extradural lesion with a left lateral extension between C7 and T1, causing spinal cord compression. The patient underwent a hemi-laminectomy of C7 and complete cyst excision through the posterior approach. His motor power improved to almost normal. Results: The patient showed good recovery of myelopathy, and he was able to walk with a cane 3 months after surgery. A 1 year followup did not reveal any recurrence or new neurological conditions. Conclusion: Cervical facet cysts are rare lesions that are occasionally signaled by progressive paraplegia but can be treated successfully by a surgical excision. Key Word: Facet cyst, Cervical spine, Progressive paraplegia
  • 6.

    Current Concept on the Surgical Treatment by Anterior Approach in Degenerative Cervical Radiculopathy

    Byung-Wan Choi | 송경진 | 2011, 18(1) | pp.34~41 | number of Cited : 1
    Study Design: A review of the literature regarding anterior cervical surgery in degenerative cervical radiculopathy. Objectives: To review and discuss anterior cervical spine surgery. Summary of Literature Review: Anterior cervical spine surgery is commonly used to treat numerous pathologic entities and is expected to increase with the development of surgical techniques and instruments. Nevertheless, there is some controversy. Materials and Methods: Literatures review. Results: Surgical treatments using the anterior approach in degenerative cervical disease have shown excellent results. A range of techniques using plate augmentation and artificial disc replacement are now accepted as effective methods. Conclusions: The appropriate method considering the pathologic status of the patient and surgeon’s surgical experience can prevent complications and lead to excellent surgical outcomes. Key Words: Degenerative cervical radiculopathy, Anterior approach, Clinical outcome