Mechanical Properties of Blood-mixed PMMA in Percutaneous Vertebroplasty

안동기; 이송; 박순열; 최대정; 우대곤; 김치훈; 김한성

Journal of Korean Society of Spine Surgery

Abbr : J Kor Spine Sur
2009, 16(4), pp.259-265
Publisher : Korean Society Of Spine Surgery
Research Area : Orthopedic Surgery

안동기 ¹, 이송 ², 박순열 ³, 최대정 ⁴, 우대곤 ⁵, 김치훈 ⁶, 김한성 ⁷

¹서울성심병원
²서울성심병원
³서울성심병원
⁴서울성심병원
⁵연세대학교
⁶연세대학교
⁷연세대학교

ABSTRACT

Study Design: This is a mechanical study of polymethylmetacrylate(PMMA) mixed with blood as a filler. Objective: We tried to change the properties of PMMA so that it is more suitable to use for percutaneous vertebroplasty (PVP). Summary of the Literature Review: The mechanical changes by adding a filler into PMMA were expected to decrease the Young’s modulus, the polymerization temperature and the setting time. These changes of PMMA were considered to be more suitable and adaptable conditions for PVP for treating osteoporotic vertebral compression fracture. Materials and Methods: Porous PMMA was produced by mixing 2 ml (B2), 4 ml (B4) and 6 ml (B6)-blood as a filler, and the mechanical properties were investigated in comparison with regular PMMA(R) in view of Young’s modulus, the polymerization temperature, the setting time and the optimal passing-time within the injectable viscosity (20~50N-needed) through a 2.8mm-diameter cement-filler tube. Porosity was inspected by performing microcomputated tomography (micro-CT). Results: Young’s modulus was decreased from 919.5 MPa (R) to 701 MPa (B2), 693.5 MPa (B4) and 545.6 MPa (B6) in each group. The polymerization temperature decreased from 74.2℃ (R) to 59.8℃ (B2), 54.2℃ (B4) and 47.5℃(B6), respectively. The setting time decreased from 1065sec (R) to 624sec (B2), 678sec(B4) and 606sec (B6), respectively, and the optimal passing-time decreased from 75.6sec (R) to 46.6sec (B2), 65.0sec (B4) and 79.0sec(B6), respectively. The porosity increased from 4.2%(R) to 27.6%(B2), 27.5%(B4) and 29.5%(B6), respectively. A homogenous microstructure with very fine pores was seen on inspection of all the blood-mixed PMMAs. Conclusion: Blood mixed with PMMA was considered as an excellent filler that was easy to make and had good biocompatibility. The 6ml blood-mixed PMMA (B6) showed more suitable mechanical properties, including a decreased elastic modulus due to more porosity, less heating and a retarded optimal passing-time by the serum barrier, which diminished the friction between the PMMA and a cement-filler tube.
KEYWORDS

Filler, Bone cement, Vertebroplasty, Osteoporotic verterbral compression fracture
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