Muscle Recovery After Sciatic Nerve Crush Injury in Rats by Different Loading Swimming Exercise

Min-Hyung RHEE; Kim, Jong-Soon

Purpose：The aim of this study was to compare the effects of different loading swimming exercises on muscle recovery after sciatic nerve crush injury in rats. Methods：For this study, thirty-one Sprague-Dawley male rats were randomly divided into five groups. There were the negative control group (NCG, n=5), the positive control group (PCG, n=7), the low intensity swimming exercise group (LISEG, n=7), the moderate intensity swimming exercise group (MISEG, n=7) and the high intensity swimming exercise group (HISEG, n=5). Each rat was weighed to determine the lead weight to be attached to the base of its tail. Subsequently, the PCG, the LISEG, the MISEG and the HISEG were underwent standard unilateral sciatic nerve crush. The LISEG (no load), the MISEG (lead weight equivalent to 2% average body mass) and the HISEG (lead weight equivalent to 4% average body mass) were received the 10 minute swimming exercise in a day for 10 days. The NCG and PCG were not received with any therapeutic intervention. The diameter of the calf muscle and the level of serum lactate dehydrogenase (LDH) were measured to detect the effects of the swimming exercise. Results：The maximum diameter of the calf muscles was significantly increased after seventh swimming exercise in the LISEG, the MISEG and the HISEG compared with the PCG (p<0.05). However, there was no statistically significant difference between the LISEG, the MISEG and the HISEG. Also, the level of the serum LDH was significantly decreased in the LISEG, the MISEG and the HISEG compared with the PCG (p<0.05). Conclusion：Taken together, these results suggest that swimming exercise could accelerate muscle recovery processes after crush injury, but the different intensity of the swimming exercise does not affect healing processes.

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* 2021년 이후 발행 논문의 참고문헌은 현재 구축 중입니다.

[journal] Ahlborn P / 2007 / One hour electrical stimulation accelerates functional recovery after femoral nerve repair / Exp Neurol 208(1) : 137~144

[journal] Ahrens RA / 1971 / Effect of dietary carbohydrate source in controlling body composition changes due to forced exercise in rats / J Nutr 101(7) : 885~888

[journal] Akassoglou K / 2002 / Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation / Neuron 33(6) : 861~875

[journal] Al-Majed AA / 2000 / Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration / J Neurosci 20(7) : 2602~2608

[journal] Contreras PC / 1995 / Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice / J Pharmacol Exp Ther 274(3) : 1443~1449

[journal] Dahlin BD / 2004 / The biology of nerve injury and repair / J Am Soc Surg Hand 4(3) : 143~155

[journal] Doyle LM / 2006 / Exercise enhances axonal growth and functional recovery in the regenerating spinal cord / Neuroscience 141(1) : 321~327

[journal] Fawcett JW / 1990 / Peripheralnerve regeneration / Annu Rev Neurosci 13 : 43~60

[journal] Ferreira LD / 2001 / Effect of streptozotocininduced diabetes on glycogen resynthesis in fasted rats post-high-intensity exercise / Am J Physiol Endocrinol Metab 280(1) : E83~E91

[book] Gage JR / 1991 / Gait analysis in cerebral palsy / Mackeith Press

[journal] Gillingwater TH / 2004 / Myo-GDNF increases non-functional polyinnervation of reinnervated mouse muscle / Neuroreport 15(1) : 21~25

[journal] Gispen WH / 1990 / Therapeutic potential for melanocortins in peripheral nerve disease / Trends Pharmacol Sci 11(6) : 221~222

[book] Guyton AC / 1986 / Textbook of medical physiology / WB Saunders

[journal] Herbison GJ / 1973 / Effect of overwork during reinnervation of rat muscle / Exp Neurol 41(1) : 1~14

[journal] Herbison GJ / 1974 / Effect of swimming on reinnervation of rat skeletal muscle / J Neurol Neurosurg Psychiatry 37(11) : 1247~1251

[journal] Herbison GJ / 1981 / Contractile properties of reinnervating skeletal muscle in the rat / Arch Phys Med Rehabil 62(1) : 35~39

[journal] Ilha J / 2008 / Endurance and resistance exercise training programs elicit specific effects on sciatic nerve regeneration after experimental traumatic lesion in rats / Neurorehabil Neural Repair 22(4) : 355~366

[journal] Jang SH / 2000 / The optimal condition for activation of motor cortex by peripheral electrical stimulation in rat / J Korean Acad Rehab Med 24(2) : 176~191

[journal] Kawanaka K / 1998 / Effects of high-intensity intermittent swimming on glucose transport in rat epitrochlearis muscle / J Appl Physiol 84(6) : 1852~1857

[journal] 김영철 / 2004 / Study on c-fos Expression in the Lumbar Spinal Cord of Sciatic Nerve Injured Rats by Ultrasound Application / Laboratory Animal Research / 한국실험동물학회 20(2) : 165~170

[journal] Lal D / 2008 / Electrical stimulation facilitates rat facial nerve recovery from a crush injury / Otolaryngol Head Neck Surg 139(1) : 68~73

[journal] Le N / 2005 / Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination / Proc Natl Acad Sci U S A 102(7) : 2596~2601

[journal] Mackinnon LT / 1994 / Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining / Int J Sports Med 15(3) : S179~S183

[book] Marieb EN / 1998 / Human Anatomy & Physiology / Pearson College Division

[journal] McNeal RL / 1990 / Aquatic therapy for patients with rheumatic disease / Rheum Dis Clin North Am 16(4) : 915~929

[journal] Meyer RS / 1997 / Functional recovery following neurorrhaphy of the rat sciatic nerve by epineurial repair compared with tubulization / J Orthop Res 15(5) : 664~669

[journal] Munro CA / 1998 / Lack of association between outcome measures of nerve regeneration / Muscle Nerve 21(8) : 1095~1097

[journal] Oh YS / 1997 / Exercise and Immunogloblin / The Korean Society of Aerovic Exercise 1(1) : 72~88

[journal] Phillips AC / 2007 / Stress and exercise: Getting the balance right for aging immunity / Exerc Sport Sci Rev 35(1) : 35~39

[journal] Raja G / 2003 / Repeated bouts of high-intensity exercise and muscle glycogen sparing in the rat / J Exp Biol 206(13) : 2159~2166

[journal] Roalstad MS / 1989 / Physiologic testing of the ultraendurance triathlete / Med Sci Sports Exerc 21(5) : S200~S204

[journal] Sacheck JM / 2001 / Role of vitamin E and oxidative stress in exercise / Nutrition 17(10) : 809~814

[journal] Schiaveto de Souza A / 2004 / Methodological evaluation to analyze functional recovery after sciatic nerve injury / J Neurotrauma 21(5) : 627~635

[journal] Shephard RJ / 1994 / Potential impact of physical activity and sport on the immune system-a brief review / Br J Sports Med 28(4) : 247~255

[journal] Simpson RJ / 2006 / The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/ activation molecules CD54(ICAM-1), CD18(beta2 integrin)and CD53 / J Appl Physiol 97(1) : 109~121

[journal] Terada S / 2002 / Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle / Biochem Biophys Res Commun 296(2) : 350~354

[journal] Terada S / 2004 / Effect of high-intensity intermittent swimming training on fatty acid oxidation enzyme activity in rat skeletal muscle / Jpn J Physiol 54(1) : 47~52

[journal] Terris DJ / 1999 / Functional recovery following nerve injury and repair by silicon tubulization : comparison of laminin-fibronectin, dialyzed plasma, collagen gel, and phosphate buffered solution / Auris Nasus Larynx 26(2) : 117~122

[book] Teodori RM / 2011 / Swimming exercise in the acute or late phase after sciatic nerve crush accelerates nerve regeneration / Neural Plast

[journal] Tharp GD / 1990 / Reduction of saliva immunoglobulin levels by swim training / Eur J Appl Physiol Occup Physiol 60(1) : 61~64

[journal] Udina E / 2008 / Electrical stimulation of intact peripheral sensory axons in rats promotes outgrowth of their central projections / Exp Neurol 210(1) : 238~247

[journal] van Meeteren NL / 1998 / The effect of exercise training on functional recovery after sciatic nerve crush in the rat / J Peripher Nerv Syst 3(4) : 277~282

[journal] Verde TJ / 1992 / Immune responses and increased training of the elite athlete / J Appl Physiol 73(4) : 1494~1499

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