This study designed and evaluated problems for nursing students’ Problem-Based Learning (PBL) in the protection of patients’ rights. The study involved a cross-sectional, descriptive survey with nonrandom, convenience sampling. The subjects, 113 senior students from two colleges of nursing, all agreed to participate in the study. Cho’s (2003) Procedure for Problem Design was applied and a measuring instrument of problem evaluation consisting of 7 items and 5 scenarios was developed by the author. Data was analyzed using a mean, t-test with the SPSS program. The mean scores for motivation were high, and statistically significant differences were not found between the two groups of students evaluated. The results suggest that PBL modules should be developed and applied to clinical conferences for students in order to improve the application of PBL. In addition, patients’ rights education through experiential learning should be implemented to change nursing students’ attitudes and improve their protective behaviors.