Purpose: The purpose of this study was to identify the factors that affect the ethical sensitivities of nurses in long-term care hospitals. Methods: This correlational study collected data from August 18, 2017, to September 8, 2017. The subjects of this study were 144 nurses working in long-term care hospitals with more than 100 beds in B-city. The study used the Ethical Sensitivity Scale for Clinical Nurses, Ethics Perception Questionnaire, Hospital Ethical Climate Survey, and Ethical Leadership Scale. Data were analyzed with the SPSS/WIN 23.0 program with descriptive statistics, independent t-test, one-way ANOVA, Pearson's correlation, and hierarchical multiple regression. Results: Educational level (β=.15 p=.017), idealism (β=.56, p<.001) among the sub- factors of ethical orientation, and ethical leadership (β=.16, p=.037) among organizational factors were the significant factors affecting the subject's ethical sensitivity, and overall explanatory power was 49.9%. Conclusion: The ethical sensitivity of hospital nurses was found to be influenced by educational level and ethical orientation (idealism) among personal factors, and ethical leadership among organizational factors. Therefore, it is necessary to consider the level of education, ethical orientation, and ethical leadership in the development of education programs to promote ethical sensitivity among nurses.