With a view to contributing to the epistemological and methodological debates in Southeast Asian Studies, the aim of this paper is to examine critically the epistemic concepts and approaches in the social sciences and then to seek an epistemic reflexivity and its potential methodological applications to Southeast Asian Studies. Although the field of social sciences has attempted to search for a means of tackling the ontological and epistemological dilemmas in its major paradigms, Southeast Asian Studies still demands a more ‘actor-centered’ epistemic account of reflexive interaction between actors and social structures. Bearing in mind the need for a more ‘actor-centered’ epistemic approach, this paper continues to discuss the ‘epistemic reflexivity’ in the social sciences and its potential applications to Southeast Asian Studies. In this paper, I will consider ‘epistemic reflexivity’ as an alternative methodological orientation. It emerges as interlinked with the ontological standpoint of what is called ‘reflexive approaches’ and its application to the detailed ‘reflexive methodology’ which I am proposing in this paper. In doing so, this paper discusses the autobiographical experiences of the author arising from his ethnographic field research in North Sulawesi, Indonesia and their implication for a reflexive methodology in Southeast Asian Studies. In conclusion, the paper argues that we need a ‘more actor-centered’ epistemic framework to compensate for the epistemological and methodological dilemmas in the social sciences and the alternative framework will equip Southeast Asian Studies with a reflexive methodology relevant to the life-dynamics of the social world in the process of developing its inquiries, methodological technics, analysis, and validation.