@article{ART003138837},
author={Won-Yung Lee and Kim Ji Hwan},
title={A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology},
journal={Journal of Sasang Constitution and Immune Medicine},
issn={1226-4075},
year={2024},
volume={36},
number={3},
pages={1-13}
TY - JOUR
AU - Won-Yung Lee
AU - Kim Ji Hwan
TI - A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology
JO - Journal of Sasang Constitution and Immune Medicine
PY - 2024
VL - 36
IS - 3
PB - The Society of Sasang Constitution and Immune Medicine
SP - 1
EP - 13
SN - 1226-4075
AB - Objectives This study explores the immunological effects of Sasang constitutional medicine (SCM) by analyzing the interaction between Bomyeongjiju herbs and immune-related processes through network pharmacology.
Methods Bomyeongjiju herbs for each Sasang type were identified from Dongmuyoogo and selected formulas, focusing on 23 herbs. Compound and target data were obtained from OASIS and related databases, creating a network of 420 targets and 1,000 interactions. Enrichment analysis was conducted using 122 immune-related Gene Ontology terms to identify significant associations by Sasang type.
Results Network analysis found that Bomyeongjiju herbs were associated with immune functions at rates significantly above chance, with an average of 18.56 immune terms per herb. So-eum’s herbs were linked to microglial and macrophage activation, So-yang’s to MyD88-dependent Toll-like receptor signaling, Tae-eum’s to leukocyte migration, and Tae-yang’s to T-helper 17 Cell Differentiation.
Conclusions Bomyeongjiju herbs demonstrate constitution-specific immunomodulatory potential, supporting SCM’s personalized approach. The findings indicate that SCM can influence distinct immune functions by constitution, which may help address immune-related diseases effectively.
KW - Sasang Constitutional Medicine;Bomyeongjiju;herbs;Network pharmacology;Immune regulation
DO -
UR -
ER -
Won-Yung Lee and Kim Ji Hwan. (2024). A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology. Journal of Sasang Constitution and Immune Medicine, 36(3), 1-13.
Won-Yung Lee and Kim Ji Hwan. 2024, "A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology", Journal of Sasang Constitution and Immune Medicine, vol.36, no.3 pp.1-13.
Won-Yung Lee, Kim Ji Hwan "A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology" Journal of Sasang Constitution and Immune Medicine 36.3 pp.1-13 (2024) : 1.
Won-Yung Lee, Kim Ji Hwan. A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology. 2024; 36(3), 1-13.
Won-Yung Lee and Kim Ji Hwan. "A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology" Journal of Sasang Constitution and Immune Medicine 36, no.3 (2024) : 1-13.
Won-Yung Lee; Kim Ji Hwan. A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology. Journal of Sasang Constitution and Immune Medicine, 36(3), 1-13.
Won-Yung Lee; Kim Ji Hwan. A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology. Journal of Sasang Constitution and Immune Medicine. 2024; 36(3) 1-13.
Won-Yung Lee, Kim Ji Hwan. A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology. 2024; 36(3), 1-13.
Won-Yung Lee and Kim Ji Hwan. "A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology" Journal of Sasang Constitution and Immune Medicine 36, no.3 (2024) : 1-13.
