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  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">compa</journal-id>
      <journal-title-group>
        <journal-title>CELLMED</journal-title>
        <trans-title-group>
          <trans-title xml:lang="ko">셀메드</trans-title>
        </trans-title-group>
      </journal-title-group>
      <issn pub-type="epub">2233-8985</issn>
      <publisher>
        <publisher-name>Cellmed Orthocellular Medicine and Pharmaceutical Association</publisher-name>
        <publisher-name xml:lang="ko">셀메드 세포교정의약학회</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">cellmed-2021-11-3-12.1</article-id>
      <article-id pub-id-type="doi">10.5667/CellMed.2021.0012</article-id>
      <article-categories>
        <subj-group>
          <subject>Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>An Overview about Treatment of Gestational Diabetes Mellitus: A Short Communication</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name name-style="western">
            <surname>Maqbool</surname>
            <given-names>Mudasir</given-names>
          </name>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="corresp" rid="cor1">*</xref>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>Zehravi</surname>
            <given-names>Mehrukh</given-names>
          </name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>Maqbool</surname>
            <given-names>Rubeena</given-names>
          </name>
          <xref ref-type="aff" rid="aff3">3</xref>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="western">
            <surname>Ara</surname>
            <given-names>Irfat</given-names>
          </name>
          <xref ref-type="aff" rid="aff4">4</xref>
        </contrib>
      </contrib-group>
      <aff id="aff1">
        <label>1</label><italic>Research Scholar, Department of Pharmaceutical Sciences, University Of Kashmir, Srinagar, Jammu and Kashmir, India</italic>
      </aff>
      <aff id="aff2">
        <label>2</label><italic>Lecturer, Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University Alkharj, Saudia Arabia</italic>
      </aff>
      <aff id="aff3">
        <label>3</label><italic>Tutor, Department of Pharmacology, GMC Baramulla, Jammu &#x26; Kashmir, India</italic>
      </aff>
      <aff id="aff4">
        <label>4</label><italic>Research officer, Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India</italic>
      </aff>
      <author-notes>
        <corresp id="cor1">
          <label>*</label>Correspondence: Mudasir Maqbool E-mail: <email>bhatmudasir92@gmail.com</email>
        </corresp>
      </author-notes>
      <pub-date pub-type="ppub">
        <day>31</day>
        <month>08</month>
        <year>2021</year>
      </pub-date>
      <volume>11</volume>
      <issue>3</issue>
      <fpage>12.1</fpage>
      <lpage>12.5</lpage>
      <history>
        <date date-type="received">
          <day>24</day>
          <month>02</month>
          <year>2021</year>
        </date>
        <date date-type="accepted">
          <day>04</day>
          <month>06</month>
          <year>2021</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright &#x000a9; 2021, Cellmed Orthocellular Medicine and Pharmaceutical Association</copyright-statement>
        <copyright-year>2021</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
          <license-p>This is an open access article under the CC BY-NC license. (<uri>http://creativecommons.org/licenses/by-nc/3.0/</uri>)</license-p>
        </license>
      </permissions>
      <abstract>
        <p>Gestational diabetes mellitus (GDM) has become one of the major public health problems for both mothers and children globally. Internationally, the frequency of excess weight and obesity has risen dramatically in women of childbearing age. There seems to be a greater risk of having GDM in overweight or obese women, resulting in problems during pregnancy, birth and neonatal development. Hospital management is a problem for obese pregnant females with GDM and places extra burdens on the healthcare sector. GDM can result in possible risks to the wellbeing of the mother, fetus, and infant, as well as clinically significant negative effects on the mental health of the mother. For females and their developing babies, diabetes may cause problems during pregnancy. Unsatisfactory diabetes control enhances the risk of complications and other birth related issues during pregnancy. It may also cause a woman to suffer severe complications. Numerous maternal and fetal effects are associated with GDM and multiple detection and management methods are also pursued globally in order to reduce the burden of health. An overview of gestational diabetes treatment is given in this review.</p>
      </abstract>
      <kwd-group>
        <kwd>Pregnancy</kwd>
        <kwd>diabetes</kwd>
        <kwd>complications</kwd>
        <kwd>treatment</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="s1" sec-type="intro">
      <title>INTRODUCTION</title>
      <p>Gestational diabetes mellitus (GDM) causes several complications during pregnancy. Adverse maternal as well as foetal effects such as elevated risk of pre-eclampsia, caesarean sections, predates, increased fetal weight with related complications and hypoglycemia have been associated with GDM (<xref ref-type="bibr" rid="r020">Group, 2002</xref>). Researches have shown that maintaining glycaemic regulation during course of pregnancy decreases the occurrence of unwanted results substantially (<xref ref-type="bibr" rid="r010">Crowther <italic>et al</italic>., 2005</xref>). Globally, the incidence of GDM has increased (<xref ref-type="bibr" rid="r001">Balarajan &#x26; Villamor, 2009</xref>; <xref ref-type="bibr" rid="r016">Ferrara, Kahn, Quesenberry, Riley, &#x26; Hedderson, 2004</xref>). The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) research reports that obesity and GDM are separate and combined risk factors that are involved in poor pregnancy outcomes (<xref ref-type="bibr" rid="r004">Catalano <italic>et al</italic>., 2012</xref>). A concurrent rise in weight in women of the reproductive age group recorded in India and neighboring countries has been reported (<xref ref-type="bibr" rid="r002">Biswas, Uddin, Mamun, Pervin, &#x26; P Garnett, 2017</xref>). Maternal, foetal, perinatal and neo-natal complications have been associated with an enhanced pre-pregnancy Body Mass Index (BMI). The Indian Ministry of Health has lowered the BMI intervention reference standards for Indians while diagnosing and managing obesity as per World Health Organization (WHO) guidelines (<xref ref-type="bibr" rid="r048">Consultation, 2004</xref>).</p>
      <sec id="s1a">
        <title>Treatment of gestational diabetes mellitus</title>
        <p>The primary objective of GDM care is to achieve good glycemic regulation that prevents/reduces fetal as well as maternal complications (<xref ref-type="bibr" rid="r027">Kim, 2010</xref>). A basic change in maternal and fetal outcomes was seen in the timely identification of GDM and treatment intervention with good glycemic regulation (<xref ref-type="bibr" rid="r010">Crowther <italic>et al</italic>., 2005</xref>).</p>
      </sec>
      <sec id="s1b">
        <title>Effects of treatment of Gestational diabetes mellitus</title>
        <p>Compared with those in the intervention group (dietary advice / insulin therapy) in a review of pregnancy outcomes among participants in the Australian Carbohydrate Intolerance Study in Pregnant Women (ACHOIS), who received routine therapy. The findings showed that counselling substantially decreased the danger of perinatal morbidity as well as showed that maternal anxiety and well-being were alleviated (<xref ref-type="bibr" rid="r021">He <italic>et al</italic>., 2016</xref>). Among the classes, rates of cesarean delivery were similar. An analysis of moderate gestational diabetics in the United States showed that there was a drop in mean birth weight, shoulder dystocia, neonatal fat mass and LGA among the fetal outcomes under care. In either party, no perinatal deaths occurred. Elevated cord blood C-peptide, hyperbilirubinemia, neonatal hypoglycemia, and birth trauma were the criteria which did not show any difference with treatment. The maternal parameters showing a substantial decrease were the number of deliveries by cesarean section and pre-eclampsia (<xref ref-type="bibr" rid="r028">Landon <italic>et al</italic>., 2009</xref>). Between intervention and routine care classes, the need for induction of labor was the same. A systematic review and meta-analysis concluded that fetal complications of macrosomia, Broad for Gestational Age (LGA), and shoulder dystocia and maternal hypertension were minimized by GDM therapeutic intervention. No major effects were observed on preterm delivery, labour induction requires, cesarean sections, pre-eclampsia, birth trauma, perinatal or neonatal morbidity and neonatal hypoglycemia (<xref ref-type="bibr" rid="r039">Poolsup, Suksomboon, &#x26; Amin, 2014</xref>). Another systematic study involving 12 studies found that the occurrence of macrosomia and shoulder dystocia was substantially decreased by GDM care. No major reductions in the number of small babies in gestational age or perinatal/neonatal deaths were observed (<xref ref-type="bibr" rid="r023">Horvath <italic>et al</italic>., 2010</xref>). Further studies have shown that the risk of developing type II diabetes in mothers has been minimized by adequate treatment of GDM (<xref ref-type="bibr" rid="r023">Horvath <italic>et al</italic>., 2010</xref>). Clinical research in females having prior exposure of GDM who were on pharmacological treatment or lifestyle intervention found that diabetes mellitus progression was reduced/delayed by up to 50% relative to those treated with placebo. The need for GDM care is aimed at ensuring minimal/nil prenatal complications as well as avoiding/delaying the production of mother and child metabolic disorder(s) (<xref ref-type="bibr" rid="r046">Seshiah, Banerjee, Balaji, Muruganathan, &#x26; Das, 2014</xref>). Strict glucose regulation and good glycemic control are involved in GDM management. Glucose levels, i.e. fasting glucose, can be tracked up to 4 times/ day and one hour after having each meal has started. After fasting, the predicted glucose levels are 70-90mg/dl and below 120mg/dl post-prandial (<xref ref-type="bibr" rid="r015">Elshahidi, 2019</xref>). A fasting glucose target of approximately 90 mg/dl and a 2-hour post-prandial glucose target of approximately 120 mg/dl have been reported in the Indian DIPSI recommendations (<xref ref-type="bibr" rid="r046">Seshiah <italic>et al</italic>., 2014</xref>).</p>
      </sec>
      <sec id="s1c">
        <title>Medical Nutritional Therapy</title>
        <p>The recommendation of medical nutritional therapy (MNT) and lifestyle changes involving physical activity is the first step towards maintaining glycemic control (<xref ref-type="bibr" rid="r018">Greuter, van Emmerik, Wouters, &#x26; van Tulder, 2012</xref>). A research from India on a detailed GDM management protocol, entitled the WINGS project, suggested two weeks of MNT and life-style intervention to follow. If normal glycemic regulation with MNT can be achieved, daily glucose level monitoring should be followed (<xref ref-type="bibr" rid="r049">Yuen &#x26; Wong, 2015</xref>). In the absence of optimum glucose levels with MNT, it was recommended that insulin or metformin therapy be initiated to treat diabetes (<xref ref-type="bibr" rid="r013">Duncan, 1882</xref>). The WINGS project proposed that only insulin be used (<xref ref-type="bibr" rid="r049">Yuen &#x26; Wong, 2015</xref>). A research also indicated that the dosage of insulin should be modified according to the needs of the particular patient. A systematic study on GDM treatment during pregnancy also found that the use of insulin over oral hypoglycemic medication was favoured by several global protocols (<xref ref-type="bibr" rid="r018">Greuter <italic>et al</italic>., 2012</xref>). MNT requires dietary intake control. The key goal of the MNT was to ensure fetal growth and to avoid ketosis (<xref ref-type="bibr" rid="r027">Kim, 2010</xref>). The control of caloric intake during GDM has been modified based on prenatal BMI. For women with normal and increased BMI groups, ACOG recommended caloric intake, composition and distribution (<xref ref-type="bibr" rid="r017">Goetzl, 2002</xref>). The goal of diet regulation was to maintain optimum gestational weight gain without compromising on fetal nutrition and growth and also without ketosis, as per Institute of Medicine (IOM) guidelines. The caloric intake requirement was similarly suggested by the Ministry of Health and Family Welfare of India. To calculate the daily energy requirement as per BMI and the degree of physical activity, be it sedentary, moderate or strong, a set of formulas has been established. 350 kcal per day was applied to the adult female energy requirement to meet the energy requirement of a pregnant woman. Finally, in the case of underweight BMI, 500kcal/day was added to the regular requirement and in the case of obese women; 500kcal/day was deducted from the requirement. In summary, the Indian recommendation has taken into account the type of physical activity performed by the subject in the calculation of the calories required per day and is also based on Indian BMI cut-off values. The role of exercise was to increase the sensitivity of insulin. Exercise to decrease the need for insulin has been documented and has also helped maintain adequate glycemic control (<xref ref-type="bibr" rid="r011">de Barros, Lopes, Francisco, Sapienza, &#x26; Zugaib, 2010</xref>; <xref ref-type="bibr" rid="r022">Horton, 1991</xref>). Exercise regimens adopted by GDM mothers have been found to decrease insulin therapy requirements and doses and also boost glycemic control (<xref ref-type="bibr" rid="r009">Cremona, O'Gorman, Cotter, Saunders, &#x26; Donnelly, 2018</xref>; <xref ref-type="bibr" rid="r044">Sanabria&#x2010;Mart&#x00ED;nez <italic>et al</italic>., 2015</xref>).</p>
      </sec>
      <sec id="s1d">
        <title>Pharmacological management of Gestational Diabetes mellitus</title>
        <p>Insulin or other medical pharmacological options should be started in subjects whose fasting and post-prandial glucose levels are not lowered by MNT (<xref ref-type="bibr" rid="r037">Dirar &#x26; Doupis, 2017</xref>; <xref ref-type="bibr" rid="r015">Elshahidi, 2019</xref>). A study stated that the majority of studies insist that only insulin is used to control GDM. Studies have confirmed, however, that oral hypoglycemic agents such as metformin can be used in GDM and have been successful in preventing complications in pregnancy, and that the protective effects of metformin are comparable to those of insulin. The investigators found that patients preferred to use metformin as opposed to insulin (<xref ref-type="bibr" rid="r029">Liang, Ma, Xiao, &#x26; Tan, 2017</xref>; <xref ref-type="bibr" rid="r042">Rowan, Hague, Gao, Battin, &#x26; Moore, 2008</xref>). Studies have been performed on the development of alternative medicinal therapies such as glyburide and glibenclamide in the treatment of GDM. Both therapies have been tested in terms of their success in preventing maternal and fetal GDM complications as well as maintaining tight glycemic regulation (<xref ref-type="bibr" rid="r024">Jayasingh Sr <italic>et al</italic>., 2020</xref>; <xref ref-type="bibr" rid="r031">Maqbool &#x26; Gani, 2018</xref>; <xref ref-type="bibr" rid="r034">Maqbool, Naeem, &#x26; Aamer, 2018</xref>).</p>
      </sec>
      <sec id="s1e">
        <title>Ayurvedic and Unani management of GDM</title>
        <p>Milk and drugs from the <italic>Madhura</italic> category are recommended during pregnancy, according to <italic>Ayurvedic</italic> texts. At certain stages of pregnancy, additional dietary components such as honey, ghee, freshly made butter, meat soup, <italic>krishra (khichadi)</italic>, and <italic>paayas (kheera)</italic> are added. Overall, the diet recommended is high in micronutrients and beneficial to both mother and child's health. Milk is a complete diet, and <italic>madhura varga</italic> medicines are both nourishing and antioxidant. Preventing gestational diabetes with a daily snack of leafy green vegetables, fruit, and milk has been shown in clinical trials. Yoga helps to alleviate anxiety, depression, and other unpleasant pregnancy symptoms. Incorporating yoga into regular pregnancy will help with anxiety, depression, and overall well-being. Yoga can potentially be an effective therapy in minimizing GD, hypertensive-related pregnancy complications, and improving fetal outcomes, according to a randomized study conducted in high-risk pregnancies (<xref ref-type="bibr" rid="r007">Chandla, Tomer, &#x26; Gupta, 2017</xref>; <xref ref-type="bibr" rid="r008">Chen <italic>et al</italic>., 2017</xref>; <xref ref-type="bibr" rid="r045">Sathananthan <italic>et al</italic>., 2015</xref>). In addition, studies have shown that the systematic and healthy implementation of a yoga therapy module can be effective in reducing stress levels in high-risk pregnancies (GDM). Yoga has previously been shown to improve the quality of life of pregnant women, improve their ability to perform social roles, and potentially avoid adverse obstetric outcomes in a noninvasive, cost-effective, and simple-to-learn study. Pregnancy is a unique phase in a woman's life, and yoga will provide her with the ability and resources to make the most of it. Meditation, breathing, and calming exercises, all of which are important components of yoga, have been shown to have a significant and beneficial effect on the autonomic nervous system's behaviours in pregnant women (<xref ref-type="bibr" rid="r007">Chandla <italic>et al</italic>., 2017</xref>; <xref ref-type="bibr" rid="r012">Deshpande <italic>et al</italic>., 2013</xref>; Khan &#x26; Maqbool; <xref ref-type="bibr" rid="r032">Maqbool, Dar, <italic>et al</italic>., 2019</xref>; <xref ref-type="bibr" rid="r040">Rakhshani, Maharana, Raghuram, Nagendra, &#x26; Venkatram, 2010</xref>).</p>
        <p><italic>Punica granatum, Trigonella foenum graecum, Gymnema sylvestre, Aloe vera, Azadirachta indica, Acacia arabica, Momordica charantia, Eugenia jambolana</italic>, and others are single drugs used in formulations with anti-diabetic and associated beneficial properties in GDM. With a comprehensive approach that involves numerous photochemical groups such as alkaloids, terpenes, and phenolics, phytomedicine used in Unani medicine offers an exciting potential for the creation of new forms of therapeutics for diabetes mellitus. These medications include antioxidants, bitter, and other activity linked to carbohydrate metabolism disturbances, in addition to hypoglycemic activity. <italic>Roghane Qusht, Sharbate Afsanteen, Qurse Tabasheer, Qurse Dhayabitus, Qurse Marwareed, Qurse Gulnar, Dawaul Misk Talkh, Safoof Gilo</italic>, and <italic>Ma-Usshaeer</italic> are some of the decoctions, infusions, capsules, pills, and powders used. <italic>Qurs Ziabetus, Qurs Kushta baiza murgh, Dolabi</italic> pills, <italic>Qurs Kushta Zamarrud, Diab-eaze, Safoof Ziabtes</italic>, and other commonly marketed formulations (<xref ref-type="bibr" rid="r019">Hamiduddin, Ali, Jahangeer, &#x26; Al, 2018</xref>; <xref ref-type="bibr" rid="r033">Maqbool, Khan, Mohammad, Adesina, &#x26; Fekadu, 2019</xref>; <xref ref-type="bibr" rid="r050">Zehravi, Maqbool, &#x26; Ara, 2021</xref>).</p>
      </sec>
    </sec>
    <sec id="s2" sec-type="discussion">
      <title>DISCUSSION</title>
      <p>GDM (gestational diabetes mellitus) is any degree of glucose sensitivity that develops or is first recognized during pregnancy (<xref ref-type="bibr" rid="r035">Metzger, Coustan, &#x26; Committee, 1998</xref>). GDM has a huge effect on both the mother and the baby's pregnancy outcomes. Despite the fact that it is recognized as a serious illness that affects pregnant women's lives, it is still a controversial topic with contradictory recommendations and treatment protocols. During pregnancy, metabolic changes occur to aid in the transition of nutrients to the developing fetus. Glucose is the most essential nutrient that crosses the placenta. While amino acids and lipids do cross the placenta, in far smaller amounts. Other vital nutrients, such as vitamins, are also needed for fetal growth and development. To ensure that certain vitamins are available to the fetus, their metabolism is impaired during pregnancy. During pregnancy, the metabolism adjusts to the needs of the developing foetus, providing a steady supply of nutrients, especially glucose, to aid in its development. Beta cell hyperplasia is promoted by elevated maternal oestrogen and progesterone during early pregnancy, resulting in an increase in insulin release (<xref ref-type="bibr" rid="r003">Carr &#x26; Gabbe, 1998</xref>; <xref ref-type="bibr" rid="r041">Rieck &#x26; Kaestner, 2010</xref>). Therefore, in early pregnancy, glucose tolerance is normal as insulin sensitivity is normal (<xref ref-type="bibr" rid="r005">Catalano, Tyzbir, Roman, Amini, &#x26; Sims, 1991</xref>; <xref ref-type="bibr" rid="r006">Catalano <italic>et al</italic>., 1992</xref>). By mid-pregnancy, however, the steady rise in fetoplacental factors has decreased maternal insulin sensitivity and stimulated the transfer of fuels other than glucose to the growing fetus (<xref ref-type="bibr" rid="r043">RYAN &#x26; ENNS, 1988</xref>). Glycemic regulation is the foundation of GDM treatment, and it has been shown to reduce adverse effects in pregnant women with GDM (<xref ref-type="bibr" rid="r036">Mills <italic>et al</italic>., 1998</xref>). Dietary counselling, also known as "Medical Nutrition Therapy," (MNT) is the first line of treatment for GDM (<xref ref-type="bibr" rid="r047">de Lima <italic>et al</italic>., 2013</xref>). MNT has been shown to help women achieve glycemic regulation and reduce pregnancy and perinatal complications. Exercise combined with dietary changes increases glycemic regulation as compared to diet alone (<xref ref-type="bibr" rid="r025">Jovanovic-Peterson, Durak, &#x26; Peterson, 1989</xref>). When women struggle to achieve their goals with traditional treatment, pharmacological intervention is used. Despite the fact that many women with GDM achieve sufficient glycemic regulation by lifestyle changes, 30-40% need additional pharmacotherapy to control hyperglycemia (<xref ref-type="bibr" rid="r014">Durnwald &#x26; Landon, 2005</xref>). Insulin is the most commonly used pharmacological treatment, but oral hypoglycemic agents (metformin and glyburide) are also gaining popularity (<xref ref-type="bibr" rid="r030">Magon &#x26; Seshiah, 2011</xref>; <xref ref-type="bibr" rid="r038">Nicholson <italic>et al</italic>., 2009</xref>). GDM is a rapidly rising issue even in poorer countries, according to recent reports from developing countries. There are additional problems in these nations. Access to GDM treatment and its affordability are other obstacles in developing countries like India, in addition to rising diabetes rates, high rates of maternal mortality and morbidity, and insufficient access to obstetric care. Unfortunately, GDM is still a neglected area that has the potential to harm the health of millions of mothers and their children. As a result, a multi-pronged approach to GDM treatment is needed.</p>
    </sec>
    <sec id="s3" sec-type="conclusions">
      <title>CONCLUSION</title>
      <p>Gestational diabetes mellitus (GDM) is a significant pregnancy complication wherein patients without previously diagnosed diabetes experience chronic hyperglycemia during gestation. In most cases, this hyperglycemia is the result of reduced glucose tolerance on the basis of chronic insulin resistance because of pancreatic &#x3B2;-cell dysfunction. Genetic, epigenetic and environmental factors are all likely to contribute to the development of GDM, and over a significant period of time, the processes involved are complex and gradual. The treatment and diagnosis of gestational diabetes is subject to much debate, stressing the significance and validity of clarification and consensus. In order to establish successful therapies and prevention strategies, greater awareness of these processes and their contribution to GDM is needed.</p>
    </sec>
  </body>
  <back>
    <fn-group>
      <fn fn-type="conflict">
        <p><bold>CONFLICT OF INTEREST</bold> None</p>
      </fn>
      <fn fn-type="supported-by">
        <p><bold>FUNDING</bold> None</p>
      </fn>
    </fn-group>
    <ack>
      <p>Authors would like to thank Miss Khushboo Nazir for her support and valuable suggestions during the compilation of this review article</p>
    </ack>
    <ref-list>
      <ref id="r001">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Balarajan</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Villamor</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Nationally representative surveys show recent increases in the prevalence of overweight and obesity among women of reproductive age in Bangladesh, Nepal, and India</article-title>
          <source>The journal of nutrition</source>
          <year>2009</year>
          <volume>139</volume>
          <issue>11</issue>
          <fpage>2139</fpage>
          <lpage>2144</lpage>
          <pub-id pub-id-type="doi">10.3945/jn.109.112029</pub-id>
        </element-citation>
      </ref>
      <ref id="r002">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Biswas</surname>
              <given-names>T</given-names>
            </name>
            <name>
              <surname>Uddin</surname>
              <given-names>MJ</given-names>
            </name>
            <name>
              <surname>Mamun</surname>
              <given-names>AA</given-names>
            </name>
            <name>
              <surname>Pervin</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>P Garnett</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Increasing prevalence of overweight and obesity in Bangladeshi women of reproductive age: Findings from 2004 to 2014</article-title>
          <source>PLoS One</source>
          <year>2017</year>
          <volume>12</volume>
          <issue>7</issue>
          <fpage>e0181080</fpage>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0181080</pub-id>
        </element-citation>
      </ref>
      <ref id="r003">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Carr</surname>
              <given-names>DB</given-names>
            </name>
            <name>
              <surname>Gabbe</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Gestational diabetes: detection, management, and implications</article-title>
          <source>Clinical Diabetes</source>
          <year>1998</year>
          <volume>16</volume>
          <issue>1</issue>
          <fpage>4</fpage>
          <lpage>12</lpage>
        </element-citation>
      </ref>
      <ref id="r004">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Catalano</surname>
              <given-names>PM</given-names>
            </name>
            <name>
              <surname>McIntyre</surname>
              <given-names>HD</given-names>
            </name>
            <name>
              <surname>Cruickshank</surname>
              <given-names>JK</given-names>
            </name>
            <name>
              <surname>McCance</surname>
              <given-names>DR</given-names>
            </name>
            <name>
              <surname>Dyer</surname>
              <given-names>AR</given-names>
            </name>
            <name>
              <surname>Metzger</surname>
              <given-names>BE</given-names>
            </name>
            <name>
              <surname>Lowe</surname>
              <given-names>LP</given-names>
            </name>
            <name>
              <surname>Trimble</surname>
              <given-names>ER</given-names>
            </name>
            <name>
              <surname>Coustan</surname>
              <given-names>DR</given-names>
            </name>
            <name>
              <surname>Hadden</surname>
              <given-names>DR</given-names>
            </name>
            <name>
              <surname>Persson</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Hod</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Oats</surname>
              <given-names>JJ</given-names>
            </name>
          </person-group>
          <article-title>The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes</article-title>
          <source>Diabetes care</source>
          <year>2012</year>
          <volume>35</volume>
          <issue>4</issue>
          <fpage>780</fpage>
          <lpage>786</lpage>
          <pub-id pub-id-type="doi">10.2337/dc11-1790</pub-id>
        </element-citation>
      </ref>
      <ref id="r005">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Catalano</surname>
              <given-names>PM</given-names>
            </name>
            <name>
              <surname>Tyzbir</surname>
              <given-names>ED</given-names>
            </name>
            <name>
              <surname>Roman</surname>
              <given-names>NM</given-names>
            </name>
            <name>
              <surname>Amini</surname>
              <given-names>SB</given-names>
            </name>
            <name>
              <surname>Sims</surname>
              <given-names>EA</given-names>
            </name>
          </person-group>
          <article-title>Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women</article-title>
          <source>American journal of obstetrics and gynecology</source>
          <year>1991</year>
          <volume>165</volume>
          <issue>6</issue>
          <fpage>1667</fpage>
          <lpage>1672</lpage>
          <pub-id pub-id-type="doi">10.1016/0002-9378(91)90012-G</pub-id>
        </element-citation>
      </ref>
      <ref id="r006">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Catalano</surname>
              <given-names>PM</given-names>
            </name>
            <name>
              <surname>Tyzbir</surname>
              <given-names>ED</given-names>
            </name>
            <name>
              <surname>Wolfe</surname>
              <given-names>RR</given-names>
            </name>
            <name>
              <surname>Roman</surname>
              <given-names>NM</given-names>
            </name>
            <name>
              <surname>Amini</surname>
              <given-names>SB</given-names>
            </name>
            <name>
              <surname>Sims</surname>
              <given-names>EA</given-names>
            </name>
          </person-group>
          <article-title>Longitudinal changes in basal hepatic glucose production and suppression during insulin infusion in normal pregnant women</article-title>
          <source>American journal of obstetrics and gynecology</source>
          <year>1992</year>
          <volume>167</volume>
          <issue>4</issue>
          <fpage>913</fpage>
          <lpage>919</lpage>
          <pub-id pub-id-type="doi">10.1016/S0002-9378(12)80011-1</pub-id>
        </element-citation>
      </ref>
      <ref id="r007">
        <element-citation publication-type="book">
          <person-group person-group-type="author">
            <name>
              <surname>Chandla</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Tomer</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Gupta</surname>
              <given-names>R</given-names>
            </name>
          </person-group>
          <source>Gestational Diabetes Mellitus; Management through Ayurveda</source>
          <year>2017</year>
        </element-citation>
      </ref>
      <ref id="r008">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Chen</surname>
              <given-names>PJ</given-names>
            </name>
            <name>
              <surname>Yang</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Chou</surname>
              <given-names>CC</given-names>
            </name>
            <name>
              <surname>Li</surname>
              <given-names>CC</given-names>
            </name>
            <name>
              <surname>Chang</surname>
              <given-names>YC</given-names>
            </name>
            <name>
              <surname>Liaw</surname>
              <given-names>JJ</given-names>
            </name>
          </person-group>
          <article-title>Effects of prenatal yoga on women’s stress and immune function across pregnancy: A randomized controlled trial</article-title>
          <source>Complementary therapies in medicine</source>
          <year>2017</year>
          <volume>31</volume>
          <fpage>109</fpage>
          <lpage>117</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ctim.2017.03.003</pub-id>
        </element-citation>
      </ref>
      <ref id="r009">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Cremona</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>O'Gorman</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Cotter</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Saunders</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Donnelly</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Effect of exercise modality on markers of insulin sensitivity and blood glucose control in pregnancies complicated with gestational diabetes mellitus: a systematic review</article-title>
          <source>Obesity science &#x26; practice</source>
          <year>2018</year>
          <volume>4</volume>
          <issue>5</issue>
          <fpage>455</fpage>
          <lpage>467</lpage>
          <pub-id pub-id-type="doi">10.1002/osp4.283</pub-id>
        </element-citation>
      </ref>
      <ref id="r010">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Crowther</surname>
              <given-names>CA</given-names>
            </name>
            <name>
              <surname>Hiller</surname>
              <given-names>JE</given-names>
            </name>
            <name>
              <surname>Moss</surname>
              <given-names>JR</given-names>
            </name>
            <name>
              <surname>McPhee</surname>
              <given-names>AJ</given-names>
            </name>
            <name>
              <surname>Jeffries</surname>
              <given-names>WS</given-names>
            </name>
            <name>
              <surname>Robinson</surname>
              <given-names>JS</given-names>
            </name>
          </person-group>
          <article-title>Effect of treatment of gestational diabetes mellitus on pregnancy outcomes</article-title>
          <source>New England Journal of Medicine</source>
          <year>2005</year>
          <volume>352</volume>
          <issue>24</issue>
          <fpage>2477</fpage>
          <lpage>2486</lpage>
          <pub-id pub-id-type="doi">10.1056/NEJMoa042973</pub-id>
        </element-citation>
      </ref>
      <ref id="r011">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>de Barros</surname>
              <given-names>MC</given-names>
            </name>
            <name>
              <surname>Lopes</surname>
              <given-names>MA</given-names>
            </name>
            <name>
              <surname>Francisco</surname>
              <given-names>RP</given-names>
            </name>
            <name>
              <surname>Sapienza</surname>
              <given-names>AD</given-names>
            </name>
            <name>
              <surname>Zugaib</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Resistance exercise and glycemic control in women with gestational diabetes mellitus</article-title>
          <source>Am J Obstet Gynecol</source>
          <year>2010</year>
          <volume>203</volume>
          <issue>6</issue>
          <fpage>556</fpage>
        </element-citation>
      </ref>
      <ref id="r012">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Deshpande</surname>
              <given-names>CS</given-names>
            </name>
            <name>
              <surname>Rakhshani</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Nagarathna</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Ganpat</surname>
              <given-names>TS</given-names>
            </name>
            <name>
              <surname>Kurpad</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Maskar</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Nagendra</surname>
              <given-names>HR</given-names>
            </name>
            <name>
              <surname>Sudheer</surname>
              <given-names>DC</given-names>
            </name>
            <name>
              <surname>Abbas</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Raghuram</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Anura</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Rita</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Ramarao</surname>
              <given-names>N</given-names>
            </name>
          </person-group>
          <article-title>Yoga for high-risk pregnancy: a randomized controlled trial</article-title>
          <source>Annals of Medical And Health Sciences Research</source>
          <year>2013</year>
          <volume>3</volume>
          <issue>3</issue>
          <fpage>341</fpage>
          <lpage>344</lpage>
          <pub-id pub-id-type="doi">10.4103/2141-9248.117933</pub-id>
        </element-citation>
      </ref>
      <ref id="r013">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Duncan</surname>
              <given-names>JM</given-names>
            </name>
          </person-group>
          <article-title>On puerperal diabetes</article-title>
          <source>Trans Obstet Soc Lond</source>
          <year>1882</year>
          <volume>24</volume>
          <fpage>256</fpage>
        </element-citation>
      </ref>
      <ref id="r014">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Durnwald</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Landon</surname>
              <given-names>MB</given-names>
            </name>
          </person-group>
          <article-title>Glyburide: The new alternative for treating gestational diabetes?</article-title>
          <source>American Journal of Obstetrics &#x26; Gynecology</source>
          <year>2005</year>
          <volume>193</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>2</lpage>
          <pub-id pub-id-type="doi">10.1016/j.ajog.2005.03.019</pub-id>
        </element-citation>
      </ref>
      <ref id="r015">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Elshahidi</surname>
              <given-names>MH</given-names>
            </name>
          </person-group>
          <article-title>Outdoor air pollution and gestational diabetes mellitus: a systematic review and meta-analysis</article-title>
          <source>Iranian Journal of Public Health</source>
          <year>2019</year>
          <volume>48</volume>
          <issue>1</issue>
          <fpage>9</fpage>
        </element-citation>
      </ref>
      <ref id="r016">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Ferrara</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Kahn</surname>
              <given-names>HS</given-names>
            </name>
            <name>
              <surname>Quesenberry</surname>
              <given-names>CP</given-names>
            </name>
            <name>
              <surname>Riley</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Hedderson</surname>
              <given-names>MM</given-names>
            </name>
          </person-group>
          <article-title>An increase in the incidence of gestational diabetes mellitus: Northern California, 1991–2000</article-title>
          <source>Obstetrics &#x26; Gynecology</source>
          <year>2004</year>
          <volume>103</volume>
          <issue>3</issue>
          <fpage>526</fpage>
          <lpage>533</lpage>
          <pub-id pub-id-type="doi">10.1097/01.AOG.0000113623.18286.20</pub-id>
        </element-citation>
      </ref>
      <ref id="r017">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Goetzl</surname>
              <given-names>LM</given-names>
            </name>
          </person-group>
          <article-title>ACOG Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin. Clinical Management Guideline for Obstetrician-Gynecologists Number 36, July 2002. Obstetric analgesia and anesthesia</article-title>
          <source>Obstet Gynecol</source>
          <year>2002</year>
          <volume>100</volume>
          <fpage>177</fpage>
          <lpage>191</lpage>
        </element-citation>
      </ref>
      <ref id="r018">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Greuter</surname>
              <given-names>MJ</given-names>
            </name>
            <name>
              <surname>van Emmerik</surname>
              <given-names>NM</given-names>
            </name>
            <name>
              <surname>Wouters</surname>
              <given-names>MG</given-names>
            </name>
            <name>
              <surname>van Tulder</surname>
              <given-names>MW</given-names>
            </name>
          </person-group>
          <article-title>Quality of guidelines on the management of diabetes in pregnancy: a systematic review</article-title>
          <source>BMC pregnancy and childbirth</source>
          <year>2012</year>
          <volume>12</volume>
          <issue>1</issue>
          <fpage>1</fpage>
          <lpage>7</lpage>
          <pub-id pub-id-type="doi">10.1186/1471-2393-12-1</pub-id>
        </element-citation>
      </ref>
      <ref id="r019">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Hamiduddin</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Ali</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Jahangeer</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Al</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Unani formulations for management of diabetes: An overview</article-title>
          <source>International Journal of Green Pharmacy</source>
          <year>2018</year>
          <volume>12</volume>
          <issue>4</issue>
          <fpage>S769</fpage>
          <lpage>S783</lpage>
        </element-citation>
      </ref>
      <ref id="r020">
        <element-citation publication-type="journal">
          <collab>HAPO Study Cooperative Research Group</collab>
          <article-title>The hyperglycemia and adverse pregnancy outcome (HAPO) study</article-title>
          <source>International Journal of Gynecology &#x26; Obstetrics</source>
          <year>2002</year>
          <volume>78</volume>
          <issue>1</issue>
          <fpage>69</fpage>
          <lpage>77</lpage>
          <pub-id pub-id-type="doi">10.1016/S0020-7292(02)00092-9</pub-id>
        </element-citation>
      </ref>
      <ref id="r021">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>He</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Curran</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>Raker</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Martin</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Larson</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Bourjeily</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Placental findings associated with maternal obesity at early pregnancy</article-title>
          <source>Pathology-Research and Practice</source>
          <year>2016</year>
          <volume>212</volume>
          <issue>4</issue>
          <fpage>282</fpage>
          <lpage>287</lpage>
          <pub-id pub-id-type="doi">10.1016/j.prp.2016.01.006</pub-id>
        </element-citation>
      </ref>
      <ref id="r022">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Horton</surname>
              <given-names>ES</given-names>
            </name>
          </person-group>
          <article-title>Exercise in the treatment of NIDDM. Applications for GDM?</article-title>
          <source>Diabetes</source>
          <year>1991</year>
          <volume>40</volume>
          <issue>Supplement 2</issue>
          <fpage>175</fpage>
          <lpage>178</lpage>
          <pub-id pub-id-type="doi">10.2337/diab.40.2.S175</pub-id>
        </element-citation>
      </ref>
      <ref id="r023">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Horvath</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Koch</surname>
              <given-names>K</given-names>
            </name>
            <name>
              <surname>Jeitler</surname>
              <given-names>K</given-names>
            </name>
            <etal>et al.</etal>
          </person-group>
          <article-title>Effects of treatment in women with gestational diabetes mellitus: systematic review and meta-analysis</article-title>
          <source>BMJ</source>
          <year>2010</year>
          <volume>340</volume>
        </element-citation>
      </ref>
      <ref id="r024">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Jayasingh</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Nanda</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Misra</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Baliarsinha</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Das</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Patil</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Comparison of Fetomaternal Outcomes in Patients With Gestational Diabetes Mellitus Treated With Insulin Versus Acarbose: Results of a Prospective, Open Label, Controlled Study</article-title>
          <source>Cureus</source>
          <year>2020</year>
          <volume>12</volume>
          <issue>12</issue>
          <fpage>e12283</fpage>
          <lpage>e12283</lpage>
        </element-citation>
      </ref>
      <ref id="r025">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Jovanovic-Peterson</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Durak</surname>
              <given-names>EP</given-names>
            </name>
            <name>
              <surname>Peterson</surname>
              <given-names>CM</given-names>
            </name>
          </person-group>
          <article-title>Randomized trial of diet versus diet plus cardiovascular conditioning on glucose levels in gestational diabetes</article-title>
          <source>American journal of obstetrics and gynecology</source>
          <year>1989</year>
          <volume>161</volume>
          <issue>2</issue>
          <fpage>415</fpage>
          <lpage>419</lpage>
          <pub-id pub-id-type="doi">10.1016/0002-9378(89)90534-6</pub-id>
        </element-citation>
      </ref>
      <ref id="r026">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Khan</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Maternal Health: An important issue</article-title>
          <source>Journal of research in health science</source>
          <year>2019</year>
          <volume>1-2</volume>
          <issue>3</issue>
          <fpage>107</fpage>
          <lpage>111</lpage>
        </element-citation>
      </ref>
      <ref id="r027">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Kim</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Gestational diabetes: risks, management, and treatment options</article-title>
          <source>International journal of women's health</source>
          <year>2010</year>
          <volume>2</volume>
          <fpage>339</fpage>
        </element-citation>
      </ref>
      <ref id="r028">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Landon</surname>
              <given-names>MB</given-names>
            </name>
            <name>
              <surname>Spong</surname>
              <given-names>CY</given-names>
            </name>
            <name>
              <surname>Thom</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Carpenter</surname>
              <given-names>MW</given-names>
            </name>
            <name>
              <surname>Ramin</surname>
              <given-names>SM</given-names>
            </name>
            <name>
              <surname>Casey</surname>
              <given-names>B</given-names>
            </name>
            <name>
              <surname>Wapner</surname>
              <given-names>RJ</given-names>
            </name>
            <name>
              <surname>Varner</surname>
              <given-names>MW</given-names>
            </name>
            <name>
              <surname>Rouse</surname>
              <given-names>DJ</given-names>
            </name>
            <name>
              <surname>Thorp</surname>
              <given-names>JM</given-names>
            </name>
            <name>
              <surname>Sciscione</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Catalano</surname>
              <given-names>P</given-names>
            </name>
            <name>
              <surname>Harper</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Saade</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Lain</surname>
              <given-names>KY</given-names>
            </name>
            <name>
              <surname>Sorokin</surname>
              <given-names>Y</given-names>
            </name>
            <name>
              <surname>Peaceman</surname>
              <given-names>AM</given-names>
            </name>
            <name>
              <surname>Tolosa</surname>
              <given-names>JE</given-names>
            </name>
            <name>
              <surname>Anderson</surname>
              <given-names>GB</given-names>
            </name>
          </person-group>
          <article-title>A multicenter, randomized trial of treatment for mild gestational diabetes</article-title>
          <source>New England Journal of Medicine</source>
          <year>2009</year>
          <volume>361</volume>
          <issue>14</issue>
          <fpage>1339</fpage>
          <lpage>1348</lpage>
          <pub-id pub-id-type="doi">10.1056/NEJMoa0902430</pub-id>
        </element-citation>
      </ref>
      <ref id="r029">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Liang</surname>
              <given-names>HL</given-names>
            </name>
            <name>
              <surname>Ma</surname>
              <given-names>SJ</given-names>
            </name>
            <name>
              <surname>Xiao</surname>
              <given-names>YN</given-names>
            </name>
            <name>
              <surname>Tan</surname>
              <given-names>HZ</given-names>
            </name>
          </person-group>
          <article-title>Comparative efficacy and safety of oral antidiabetic drugs and insulin in treating gestational diabetes mellitus: an updated PRISMA-compliant network meta-analysis</article-title>
          <source>Medicine</source>
          <year>2017</year>
          <volume>96</volume>
          <issue>38</issue>
        </element-citation>
      </ref>
      <ref id="r030">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Magon</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Seshiah</surname>
              <given-names>V</given-names>
            </name>
          </person-group>
          <article-title>Gestational diabetes mellitus: Non-insulin management</article-title>
          <source>Indian journal of endocrinology and metabolism</source>
          <year>2011</year>
          <volume>15</volume>
          <issue>4</issue>
          <fpage>284</fpage>
          <pub-id pub-id-type="doi">10.4103/2230-8210.85580</pub-id>
        </element-citation>
      </ref>
      <ref id="r031">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Gani</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
          <article-title>Utilization of Statins in Reducing Comorbidities of Diabetes Mellitus: A Systematic Review</article-title>
          <source>Journal of Pharmacy Practice and Community Medicine</source>
          <year>2018</year>
          <volume>4</volume>
          <issue>4</issue>
        </element-citation>
      </ref>
      <ref id="r032">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Dar</surname>
              <given-names>MA</given-names>
            </name>
            <name>
              <surname>Gani</surname>
              <given-names>I</given-names>
            </name>
            <name>
              <surname>Mir</surname>
              <given-names>SA</given-names>
            </name>
            <name>
              <surname>Khan</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Bhat</surname>
              <given-names>AU</given-names>
            </name>
          </person-group>
          <article-title>Maternal Health and Nutrition in Pregnancy: an Insight</article-title>
          <source>World Journal of Pharmacy and Pharmaceutical Sciences</source>
          <year>2019</year>
          <volume>8</volume>
          <issue>3</issue>
          <fpage>450</fpage>
          <lpage>459</lpage>
        </element-citation>
      </ref>
      <ref id="r033">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Khan</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Mohammad</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Adesina</surname>
              <given-names>MA</given-names>
            </name>
            <name>
              <surname>Fekadu</surname>
              <given-names>G</given-names>
            </name>
          </person-group>
          <article-title>Awareness about reproductive health in adolescents and youth: A review</article-title>
          <source>Journal of Applied Pharmaceutical Sciences and Research</source>
          <year>2019</year>
          <fpage>1</fpage>
          <lpage>5</lpage>
        </element-citation>
      </ref>
      <ref id="r034">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Naeem</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Aamer</surname>
              <given-names>S</given-names>
            </name>
          </person-group>
          <article-title>Diabetes Mellitus and Its Various Management Strategies in Practice</article-title>
          <source>Indo American Journal of Pharmaceutical Sciences</source>
          <year>2018</year>
          <volume>5</volume>
          <issue>8</issue>
          <fpage>8163</fpage>
          <lpage>8173</lpage>
        </element-citation>
      </ref>
      <ref id="r035">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Metzger</surname>
              <given-names>BE</given-names>
            </name>
            <name>
              <surname>Coustan</surname>
              <given-names>DR</given-names>
            </name>
            <name>
              <surname>Committee</surname>
              <given-names>O</given-names>
            </name>
          </person-group>
          <article-title>Summary and recommendations of the fourth international workshop-conference on gestational diabetes mellitus</article-title>
          <source>Diabetes care</source>
          <year>1998</year>
          <volume>21</volume>
          <fpage>B161</fpage>
        </element-citation>
      </ref>
      <ref id="r036">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Mills</surname>
              <given-names>JL</given-names>
            </name>
            <name>
              <surname>Jovanovic</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Knopp</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Aarons</surname>
              <given-names>J</given-names>
            </name>
            <name>
              <surname>Conley</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Park</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Lee</surname>
              <given-names>YJ</given-names>
            </name>
            <name>
              <surname>Holmes</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Simpson</surname>
              <given-names>JL</given-names>
            </name>
            <name>
              <surname>Metzger</surname>
              <given-names>B</given-names>
            </name>
          </person-group>
          <article-title>Physiological reduction in fasting plasma glucose concentration in the first trimester of normal pregnancy: the diabetes in early pregnancy study</article-title>
          <source>Metabolism</source>
          <year>1998</year>
          <volume>47</volume>
          <issue>9</issue>
          <fpage>1140</fpage>
          <lpage>1144</lpage>
          <pub-id pub-id-type="doi">10.1016/S0026-0495(98)90290-6</pub-id>
        </element-citation>
      </ref>
      <ref id="r037">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Mirghani Dirar</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Doupis</surname>
              <given-names>J</given-names>
            </name>
          </person-group>
          <article-title>Gestational diabetes from A to Z</article-title>
          <source>World journal of diabetes</source>
          <year>2017</year>
          <volume>8</volume>
          <issue>12</issue>
          <fpage>489</fpage>
          <lpage>511</lpage>
          <pub-id pub-id-type="doi">10.4239/wjd.v8.i12.489</pub-id>
        </element-citation>
      </ref>
      <ref id="r038">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Nicholson</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Bolen</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Witkop</surname>
              <given-names>CT</given-names>
            </name>
            <name>
              <surname>Neale</surname>
              <given-names>D</given-names>
            </name>
            <name>
              <surname>Wilson</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Bass</surname>
              <given-names>E</given-names>
            </name>
          </person-group>
          <article-title>Benefits and risks of oral diabetes agents compared with insulin in women with gestational diabetes: a systematic review</article-title>
          <source>Obstetrics &#x26; Gynecology</source>
          <year>2009</year>
          <volume>113</volume>
          <issue>1</issue>
          <fpage>193</fpage>
          <lpage>205</lpage>
          <pub-id pub-id-type="doi">10.1097/AOG.0b013e318190a459</pub-id>
        </element-citation>
      </ref>
      <ref id="r039">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Poolsup</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Suksomboon</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Amin</surname>
              <given-names>M</given-names>
            </name>
          </person-group>
          <article-title>Effect of treatment of gestational diabetes mellitus: a systematic review and meta-analysis</article-title>
          <source>PLoS One</source>
          <year>2014</year>
          <volume>9</volume>
          <issue>3</issue>
          <fpage>e92485</fpage>
          <pub-id pub-id-type="doi">10.1371/journal.pone.0092485</pub-id>
        </element-citation>
      </ref>
      <ref id="r040">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Rakhshani</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Maharana</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Raghuram</surname>
              <given-names>N</given-names>
            </name>
            <name>
              <surname>Nagendra</surname>
              <given-names>HR</given-names>
            </name>
            <name>
              <surname>Venkatram</surname>
              <given-names>P</given-names>
            </name>
          </person-group>
          <article-title>Effects of integrated yoga on quality of life and interpersonal relationship of pregnant women</article-title>
          <source>Quality of life Research</source>
          <year>2010</year>
          <volume>19</volume>
          <issue>10</issue>
          <fpage>1447</fpage>
          <lpage>1455</lpage>
          <pub-id pub-id-type="doi">10.1007/s11136-010-9709-2</pub-id>
        </element-citation>
      </ref>
      <ref id="r041">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Rieck</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Kaestner</surname>
              <given-names>KH</given-names>
            </name>
          </person-group>
          <article-title>Expansion of &#x3B2;-cell mass in response to pregnancy</article-title>
          <source>Trends in Endocrinology &#x26; Metabolism</source>
          <year>2010</year>
          <volume>21</volume>
          <issue>3</issue>
          <fpage>151</fpage>
          <lpage>158</lpage>
          <pub-id pub-id-type="doi">10.1016/j.tem.2009.11.001</pub-id>
        </element-citation>
      </ref>
      <ref id="r042">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Rowan</surname>
              <given-names>JA</given-names>
            </name>
            <name>
              <surname>Hague</surname>
              <given-names>WM</given-names>
            </name>
            <name>
              <surname>Gao</surname>
              <given-names>W</given-names>
            </name>
            <name>
              <surname>Battin</surname>
              <given-names>MR</given-names>
            </name>
            <name>
              <surname>Moore</surname>
              <given-names>MP</given-names>
            </name>
          </person-group>
          <article-title>Metformin versus insulin for the treatment of gestational diabetes</article-title>
          <source>New England Journal of Medicine</source>
          <year>2008</year>
          <volume>358</volume>
          <issue>19</issue>
          <fpage>2003</fpage>
          <lpage>2015</lpage>
          <pub-id pub-id-type="doi">10.1056/NEJMoa0707193</pub-id>
        </element-citation>
      </ref>
      <ref id="r043">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Ryan</surname>
              <given-names>EA</given-names>
            </name>
            <name>
              <surname>Enns</surname>
              <given-names>L</given-names>
            </name>
          </person-group>
          <article-title>Role of gestational hormones in the induction of insulin resistance</article-title>
          <source>The Journal of Clinical Endocrinology &#x26; Metabolism</source>
          <year>1988</year>
          <volume>67</volume>
          <issue>2</issue>
          <fpage>341</fpage>
          <lpage>347</lpage>
          <pub-id pub-id-type="doi">10.1210/jcem-67-2-341</pub-id>
        </element-citation>
      </ref>
      <ref id="r044">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Sanabria-Mart&#x00ED;nez</surname>
              <given-names>G</given-names>
            </name>
            <name>
              <surname>Garc&#x00ED;a-Hermoso</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Poyatos-Le&#x00F3;n</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>&#x00C1;lvarez-Bueno</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Sánchez-L&#x00F3;pez</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Martínez-Vizca&#x00ED;no</surname>
              <given-names>V</given-names>
            </name>
          </person-group>
          <article-title>Effectiveness of physical activity interventions on preventing gestational diabetes mellitus and excessive maternal weight gain: a meta‐analysis</article-title>
          <source>BJOG: An International Journal of Obstetrics &#x26; Gynaecology</source>
          <year>2015</year>
          <volume>122</volume>
          <issue>9</issue>
          <fpage>1167</fpage>
          <lpage>1174</lpage>
          <pub-id pub-id-type="doi">10.1111/1471-0528.13429</pub-id>
        </element-citation>
      </ref>
      <ref id="r045">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Sathananthan</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Shah</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Edens</surname>
              <given-names>KL</given-names>
            </name>
            <name>
              <surname>Grothe</surname>
              <given-names>KB</given-names>
            </name>
            <name>
              <surname>Piccinini</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Farrugia</surname>
              <given-names>LP</given-names>
            </name>
            <name>
              <surname>Micheletto</surname>
              <given-names>F</given-names>
            </name>
            <name>
              <surname>Man</surname>
              <given-names>CD</given-names>
            </name>
            <name>
              <surname>Cobelli</surname>
              <given-names>C</given-names>
            </name>
            <name>
              <surname>Rizza</surname>
              <given-names>RA</given-names>
            </name>
            <name>
              <surname>Camilleri</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Vella</surname>
              <given-names>A</given-names>
            </name>
          </person-group>
          <article-title>Six and 12 weeks of caloric restriction increases &#x03B2; cell function and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes</article-title>
          <source>The Journal of Nutrition</source>
          <year>2015</year>
          <volume>145</volume>
          <issue>9</issue>
          <fpage>2046</fpage>
          <lpage>2051</lpage>
          <pub-id pub-id-type="doi">10.3945/jn.115.210617</pub-id>
        </element-citation>
      </ref>
      <ref id="r046">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Seshiah</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>Banerjee</surname>
              <given-names>S</given-names>
            </name>
            <name>
              <surname>Balaji</surname>
              <given-names>V</given-names>
            </name>
            <name>
              <surname>Muruganathan</surname>
              <given-names>A</given-names>
            </name>
            <name>
              <surname>Das</surname>
              <given-names>AK</given-names>
            </name>
          </person-group>
          <article-title>Consensus evidence-based guidelines for management of gestational diabetes mellitus in India</article-title>
          <source>J Assoc Physicians India</source>
          <year>2014</year>
          <volume>62</volume>
          <issue>7 Suppl</issue>
          <fpage>55</fpage>
          <lpage>62</lpage>
        </element-citation>
      </ref>
      <ref id="r047">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Thomaz de Lima</surname>
              <given-names>H</given-names>
            </name>
            <name>
              <surname>Lopes Rosado</surname>
              <given-names>E</given-names>
            </name>
            <name>
              <surname>Ribeiro Neves</surname>
              <given-names>PA</given-names>
            </name>
            <name>
              <surname>Corr&#x00EA;a Monteiro Machado</surname>
              <given-names>R</given-names>
            </name>
            <name>
              <surname>Mello de Oliveira</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Saunders</surname>
              <given-names>C</given-names>
            </name>
          </person-group>
          <article-title>Systematic review; Nutritional therapy in gestational diabetes mellitus</article-title>
          <source>Nutr Hosp</source>
          <year>2013</year>
          <volume>28</volume>
          <issue>6</issue>
          <fpage>1806</fpage>
          <lpage>1814</lpage>
        </element-citation>
      </ref>
      <ref id="r048">
        <element-citation publication-type="journal">
          <collab>WHO Expert Consultation</collab>
          <article-title>Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies</article-title>
          <source>Lancet</source>
          <year>2004</year>
          <volume>363</volume>
          <issue>9403</issue>
          <fpage>157</fpage>
          <lpage>163</lpage>
          <pub-id pub-id-type="doi">10.1016/S0140-6736(03)15268-3</pub-id>
        </element-citation>
      </ref>
      <ref id="r049">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Yuen</surname>
              <given-names>L</given-names>
            </name>
            <name>
              <surname>Wong</surname>
              <given-names>VW</given-names>
            </name>
          </person-group>
          <article-title>Gestational diabetes mellitus: challenges for different ethnic groups</article-title>
          <source>World journal of diabetes</source>
          <year>2015</year>
          <volume>6</volume>
          <issue>8</issue>
          <fpage>1024</fpage>
          <pub-id pub-id-type="doi">10.4239/wjd.v6.i8.1024</pub-id>
        </element-citation>
      </ref>
      <ref id="r050">
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Zehravi</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Maqbool</surname>
              <given-names>M</given-names>
            </name>
            <name>
              <surname>Ara</surname>
              <given-names>I</given-names>
            </name>
          </person-group>
          <article-title>Polycystic ovary syndrome and reproductive health of women: a curious association</article-title>
          <source>International Journal of Adolescent Medicine and Health</source>
          <year>2021</year>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>
