<?xml version="1.0" encoding="UTF-8"?>
<?xml-stylesheet type="text/xsl" href="/resources/xsl/jats-html.xsl"?>
<article article-type="research-article" dtd-version="1.2" xml:lang="en" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <front>
    <journal-meta>
      <journal-id journal-id-type="publisher-id">compa</journal-id>
      <journal-title-group>
        <journal-title>CELLMED</journal-title>
        <trans-title-group>
          <trans-title xml:lang="ko">셀메드</trans-title>
        </trans-title-group>
      </journal-title-group>
      <issn pub-type="epub">2233-8985</issn>
      <publisher>
        <publisher-name>Cellmed Orthocellular Medicine and Pharmaceutical Association</publisher-name>
        <publisher-name xml:lang="ko">셀메드 세포교정의약학회</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">cellmed-2023-13-1-8.1</article-id>
      <article-id pub-id-type="doi">10.5667/CellMed.spc.008</article-id>
      <article-categories>
        <subj-group>
          <subject>Article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>A Case Study of a Patient with Diabetes who Received Ortho-Cellular Nutrition Therapy (OCNT)</article-title>
        <trans-title-group xml:lang="ko">
          <trans-title>세포교정영양요법(OCNT)을 이용한 당뇨 환자 사례 연구</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes" rid="aff1">
          <name-alternatives>
            <name name-style="eastern" xml:lang="ko">
              <surname>최</surname>
              <given-names>연</given-names>
            </name>
            <name name-style="western">
              <surname>Choi</surname>
              <given-names>Yeon</given-names>
            </name>
          </name-alternatives>
        </contrib>
      </contrib-group>
      <aff-alternatives id="aff1">
        <aff xml:lang="ko">약사, 광주 서구 운천로 88 운진 빌딩 한샘 약국</aff>
        <aff>Pharmacist, Hansaem Pharmacy, 88 Unjin Building, Uncheon-ro, Seo-gu, Gwangju, Republic of Korea</aff>
      </aff-alternatives>
      <author-notes>
        <corresp id="cor1">
          <label>*</label>Correspondence: Yeon choi E-mail: <email>cy386@hanmail.net</email>
        </corresp>
        <corresp id="cor2">
          <label>&#x2628;</label>This report has been translated and edited by the CellMed editor-in-chief, Prof. Beom-Jin Lee.
        </corresp>
      </author-notes>
      <pub-date pub-type="ppub">
        <day>31</day>
        <month>01</month>
        <year>2023</year>
      </pub-date>
      <volume>13</volume>
      <issue>1</issue>
      <fpage>8.1</fpage>
      <lpage>8.3</lpage>
      <history>
        <date date-type="received">
          <day>31</day>
          <month>01</month>
          <year>2023</year>
        </date>
        <date date-type="accepted">
          <day>31</day>
          <month>01</month>
          <year>2023</year>
        </date>
      </history>
      <permissions>
        <copyright-statement>Copyright &#x000a9; 2023, Cellmed Orthocellular Medicine and Pharmaceutical Association</copyright-statement>
        <copyright-year>2023</copyright-year>
        <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
          <license-p>This is an open access article under the CC BY-NC license. (<uri>http://creativecommons.org/licenses/by-nc/3.0/</uri>)</license-p>
        </license>
      </permissions>
      <abstract>
        <sec>
          <title>Objective</title>
          <p>: A Case Report on Control of Diabetes Using Nutritional Therapy</p>
        </sec>
        <sec>
          <title>Methods</title>
          <p>: The patient is a Korean woman aged 58 years. The patient has a history of cervical cancer surgery and is a diabetic patient.</p>
        </sec>
        <sec>
          <title>Results</title>
          <p>: Diabetes improved following nutritional therapy.</p>
        </sec>
        <sec>
          <title>Conclusion</title>
          <p>: Nutritional therapy can be beneficial in the treatment of diabetes.</p>
        </sec>
      </abstract>
      <kwd-group>
        <kwd>Ortho-Cellular Nutrition Therapy (OCNT)</kwd>
        <kwd>diabetes</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="s1" sec-type="intro">
      <title>Introduction</title>
      <p>Diabetes is a major health problem in Korea, but little attention is paid to the quality of life of diabetic patients. The 4th National Health and Nutrition Examination Survey (2007-2009) investigated the effect of diabetes on health-related quality of life. Regardless of blood glucose level, patients with diabetes had a significantly lower HRQoL (Health-related QOL refers to QOL in the medical field that considers the patient's physical and mental functions.) than those without diabetes.<sup><xref ref-type="bibr" rid="r001">1</xref></sup></p>
      <p>The patient is a 58-year-old female with a history of cervical cancer surgery and a one-year history of diabetes.</p>
      <p>Through this case, we hope to demonstrate the success of nutritional therapy for diabetes patients.</p>
    </sec>
    <sec id="s2" sec-type="other">
      <title>Case</title>
      <sec id="s2a">
        <title>1. Subject</title>
        <p>The subject was a patient diagnosed with cancer.</p>
        <p><bold>1) Name</bold>: O O (F/58)</p>
        <p><bold>2) Diagnosis</bold>: Type 2 Diabetes (OO Hospital)</p>
        <p><bold>3) Onset Date</bold>: 2020</p>
        <p><bold>4) Treatment period</bold>: July 2021 ~ Present</p>
        <p><bold>5) Main complaint</bold>: Hospitalized for rehabilitation after cancer surgery, looking older than age, chronic fatigue, inability to control fasting blood sugar, and dull skin.</p>
        <p><bold>6) Past history</bold>: Diabetes and hyperlipidemia drugs start in 2020 and cervical cancer surgery in April 2021</p>
        <p><bold>7) Social History</bold>: drinking once a week</p>
        <p><bold>8) Family History</bold>: stomach cancer (Mother)</p>
        <p><bold>9) Current medical history and medication</bold>: Visiting internal medicine once a month for blood sugar monitoring, and maintaining normal fasting blood sugar levels (99-110)</p>
      </sec>
      <sec id="s2b">
        <title>2. Method</title>
        <p>The patient was hospitalized and managed in a cancer rehabilitation hospital following surgery for cervical cancer, and she was taking diabetes medication (Januvia 100 mg) and hyperlipidemia medication.</p>
        <p>Nutritional therapy was implemented from July to December 2021. The prescription of medication administered was Cyaplex F 101, Eufaplex 101, Momoplex 101, T.M. Plex 2 capsules, Aqua Pure 1 pack, Collaplex, VIVAGIN X, and Bioplex. From January to July 2022, Cyaplex capsule 303, Eufaplex Stick 101, Momoplex 101, T.M. Plus 2 Capsule, Bioplex 001, VIVAGIN X 2 Capsule, Collaplex 1 Pack, Aqua Pure 1 Pack was prescribed.</p>
      </sec>
    </sec>
    <sec id="s3" sec-type="results">
      <title>Results</title>
      <p>From July to December 2021, OCNT treatment resulted in maintained fasting blood glucose between 110 mg/dL and 125 mg/dL, and HbA1c was 5.9%. The patient returned to a condition that was extremely satisfactory, avoided overeating, and maintained a restrained lifestyle. Then, from January to May of 2022, the fasting blood glucose was maintained between 99 mg/dL and 113 mg/dL, and the glycated hemoglobin was kept at 6.0%. A June 2022 recommendation from an internal medicine specialist led to the discontinuation of the diabetes medication Januvia.</p>
      <p>After stopping Januvia, after July 2022, the fasting blood sugar level was maintained at 113 mg/dL and 120 mg/dL 2 hours after eating. From August to November 2022, the prescription was changed to Cyaplex Alpha 101, Eufaplex Capsule 303, Momoplex 101, Bioplex 01, VIVAGIN X 2 Capsule, Diverol 1 Capsule, and on the morning of November 11, fasting blood sugar was 99mg/dL, the patient had lost 3kg and her general condition improved.</p>
      <fig id="f001" position="float">
        <label>[Figure 1]</label>
        <caption>
          <title>November 11, 2022, Fasting Blood Sugar Improved to 99 mg/dL.</title>
        </caption>
        <graphic xlink:href="../ingestImageView?artiId=ART002927929&amp;imageName=cellmed-2023-13-1-8.1-f001.jpg" position="float"/>
      </fig>
    </sec>
    <sec id="s4" sec-type="discussion">
      <title>Discussion</title>
      <p>Self-management, such as diet regulation and exercise, is required to overcome diabetes.<sup><xref ref-type="bibr" rid="r002">2</xref></sup> Therefore, it is quite challenging for modern individuals to overcome diabetes. This case report describes a single case in which nutritional therapy was proposed to research treatment for improving diabetes.</p>
      <p>It is presumed that in Cyaplex F prevent insulin resistance<sup><xref ref-type="bibr" rid="r003">3</xref></sup>, and it is hypothesized that Vivagin X's vitamin C, an antioxidant, reduces insulin resistance by enhancing conditions that reduce oxidative stress parameters<sup><xref ref-type="bibr" rid="r004">4</xref></sup>.</p>
      <p>In addition, zinc in T.M.plex is involved in insulin production and secretion<sup><xref ref-type="bibr" rid="r005">5</xref></sup>, chromium improves insulin cell sensitivity<sup><xref ref-type="bibr" rid="r006">6</xref></sup>, and Bitter Melon (Momordica charanitia fruit) extract<sup><xref ref-type="bibr" rid="r007">7</xref></sup> contained in Momoplex have been shown to have a pronounced effect in clinical tests for treating type 1 and type 2 diabetes.</p>
      <p>Due to the possibility that this nutritional therapy may be an additional treatment option for diabetes patients, the patient consented to the publication of this report.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="r001">
        <label>1</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Choi</surname>
              <given-names>Y. J.</given-names>
            </name>
            <etal>et al.</etal>
          </person-group>
          <article-title>The Relationship between Diabetes Mellitus and Health-Related Quality of Life in Korean Adults: The Fourth Korea National Health and Nutrition Examination Survey (2007-2009)</article-title>
          <source>Diabetes Metab J</source>
          <year>2011</year>
          <volume>35</volume>
          <fpage>587</fpage>
          <lpage>594</lpage>
          <pub-id pub-id-type="doi">10.4093/dmj.2011.35.6.587</pub-id>
        </element-citation>
      </ref>
      <ref id="r002">
        <label>2</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Burgers</surname>
              <given-names>J. S.</given-names>
            </name>
            <etal>et al.</etal>
          </person-group>
          <article-title>Inside Guidelines: Comparative analysis of recommendations and evidence in diabetes guidelines from 13 countries</article-title>
          <source>Diabetes Care</source>
          <year>2002</year>
          <volume>25</volume>
          <fpage>1933</fpage>
          <lpage>1939</lpage>
          <pub-id pub-id-type="doi">10.2337/diacare.25.11.1933</pub-id>
        </element-citation>
      </ref>
      <ref id="r003">
        <label>3</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Li</surname>
              <given-names>D.</given-names>
            </name>
            <name>
              <surname>Zhang</surname>
              <given-names>Y.</given-names>
            </name>
            <name>
              <surname>Liu</surname>
              <given-names>Y.</given-names>
            </name>
            <name>
              <surname>Sun</surname>
              <given-names>R.</given-names>
            </name>
            <name>
              <surname>Xia</surname>
              <given-names>M.</given-names>
            </name>
          </person-group>
          <article-title>Purified Anthocyanin Supplementation Reduces Dyslipidemia, Enhances Antioxidant Capacity, and Prevents Insulin Resistance in Diabetic Patients</article-title>
          <source>The Journal of Nutrition</source>
          <year>2015</year>
          <volume>145</volume>
          <fpage>742</fpage>
          <lpage>748</lpage>
          <pub-id pub-id-type="doi">10.3945/jn.114.205674</pub-id>
        </element-citation>
      </ref>
      <ref id="r004">
        <label>4</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Rafighi</surname>
              <given-names>Z.</given-names>
            </name>
            <name>
              <surname>Shiva</surname>
              <given-names>A.</given-names>
            </name>
            <name>
              <surname>Arab</surname>
              <given-names>S.</given-names>
            </name>
            <name>
              <surname>Mohd Yousof</surname>
              <given-names>R.</given-names>
            </name>
          </person-group>
          <article-title>Association of dietary vitamin C and e intake and antioxidant enzymes in type 2 diabetes mellitus patients</article-title>
          <source>Glob J Health Sci</source>
          <year>2013</year>
          <volume>5</volume>
          <fpage>183</fpage>
          <lpage>187</lpage>
          <pub-id pub-id-type="doi">10.5539/gjhs.v5n3p183</pub-id>
        </element-citation>
      </ref>
      <ref id="r005">
        <label>5</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Fukunaka</surname>
              <given-names>A.</given-names>
            </name>
            <name>
              <surname>Fujitani</surname>
              <given-names>Y.</given-names>
            </name>
          </person-group>
          <article-title>Role of Zinc Homeostasis in the Pathogenesis of Diabetes and Obesity</article-title>
          <source>International Journal of Molecular Sciences</source>
          <year>2018</year>
          <volume>19</volume>
          <fpage>476</fpage>
          <pub-id pub-id-type="doi">10.3390/ijms19020476</pub-id>
        </element-citation>
      </ref>
      <ref id="r006">
        <label>6</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Pechova</surname>
              <given-names>A.</given-names>
            </name>
            <name>
              <surname>Pavlata</surname>
              <given-names>L.</given-names>
            </name>
          </person-group>
          <article-title>Chromium as an essential nutrient: a review</article-title>
          <source>Veterinární medicína</source>
          <year>2007</year>
          <volume>52</volume>
          <fpage>1</fpage>
        </element-citation>
      </ref>
      <ref id="r007">
        <label>7</label>
        <element-citation publication-type="journal">
          <person-group person-group-type="author">
            <name>
              <surname>Mohammady</surname>
              <given-names>I.</given-names>
            </name>
            <name>
              <surname>Elattar</surname>
              <given-names>S.</given-names>
            </name>
            <name>
              <surname>Mohammed</surname>
              <given-names>S.</given-names>
            </name>
            <name>
              <surname>Ewais</surname>
              <given-names>M.</given-names>
            </name>
          </person-group>
          <article-title>An evaluation of anti-diabetic and anti-lipidemic properties of Momordica charantia (Bitter Melon) fruit extract in experimentally induced diabetes</article-title>
          <source>Life Sci J</source>
          <year>2012</year>
          <volume>9</volume>
          <fpage>363</fpage>
          <lpage>374</lpage>
        </element-citation>
      </ref>
    </ref-list>
  </back>
</article>
