Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Hair Growth Promoting Effect of Saengbal-eum(Sh？ngf？-y？n) Application on Hair-Removed C57BL/6 Mouse
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2007, 17(2), pp.101-121
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
이상학 1, Mi-Yeon Song 1, Chung, Seok Hee 1, SHIN HYUN DAE 1
1경희대학교
Candidate
ABSTRACT
Objectives :
Saengbal-eum(Shēngfà-yǐn) is a hair care product which is composed of eight plant extracts used in oriental medicine. This study was carried out to investigate effect of Saengbal-eum(Shēngfà-yǐn) on hair regrowth in a shaving model of C57BL6 mice.
Materials and Methods :
Five-week-old mice were acclimated for 1 week under 21~23℃, 40~60% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including normal saline(control), a positive control of 3% Minoxidil(MXD), and 30%, 100% Saengbal-eum(Shēngfà-yǐn) extracts(sample-I, II) for 12 female mice. The test compounds were topically treated once a day for 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-β1 and EGF were also determined using a immunohistochemistry.
Results :
The topical application of 3% MXD and Saengbal-eum(Shēngfà-yǐn) in female mice promoted hair regrowth earlier and faster than the control groups. Concentrations of hairs and thick-hair ratio in 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups were promoted than control group. There was not significant difference of hair regrowth, concentration of hair, and thick-hair ratio between 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups. TGF-β1 was not revealed in control, 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups. EGF was strongly positive in out root sheat of some thick hair of 30%, 100% Saengbal-eum(Shēngfà-yǐn) group, but negative in control and 3% MXD group.
Conclusions :
These results suggest that Saengbal-eum(Shēngfà-yǐn) has hair growth promoting activity and it can be for treatment for alopecia. And these effects relate to EGF revelation of hair roots.
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[journal]
/ 2005
/ 두피 모발질환
/ 서울:군자출판사
: 1~73
[journal]
Mitsui S
/ 1997
/ Gene for a range of growth factors and cyclin-dependent kinase inhibitors are expressed by isolated human hair follicle
137
: 693~
[journal]
Inui S
/ 2002
/ Androgen-inducible TGF-beta1 from balding dermal papilla cells inhibits epithelial cell growth: a clue to understand paradoxical effects of androgen on human hair growth
16(14)
: 1967~1969
[journal]
Mak KK
/ 2003
/ Epidermal growth factor as a biologic switch in hair growth cycle
278(28)
: 26120~26126
[journal]
Messenger AG
/ 2004
/ Minoxidil: mechanisms of action on hair growth
150(2)
: 186~194
[journal]
Schweikert HU
/ 1974
/ Regulation of human hair growth by steroid hormones Testerone metabolism in isolated hairs
j clin endocri(l metab)
: 811~9
[journal]
Libecco JF
/ 2004.04
/ Finasteride in the treatment of alopecia
5(4)
: 933~940
[journal]
Hoedemaker C
/ 2007
/ Treatment of female pattern hair loss with a combination of spironolactone and minoxidil
48(1)
: 43~45
[journal]
Karyn S
/ 2003
/ Common Hair Loss Disorders
68(1)
: 93~102
[journal]
임사비나
/ 1999
/ 탈모에 대한 동서의학적 고찰
4(1)
: 699~710
[journal]
Roh SS
/ 2002
/ The hair growth promoting effect of Sophora flavescens extract and its molecular regulation
30(1)
: 43~49
[journal]
Kwon OS
/ 2006
/ Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG)
/ Phytomedicine
: 6~
[journal]
Wu QY
/ 2006.07
/ Effects of traditional Chinese herbs on growth of mouse hair follicles and hair bulb cells in vitro
35(4)
: 435~439
[journal]
Gao SP
/ 2007
/ Effects of Huoxue Bushen Mixture on skin blood vessel neogenesis and vascular endothelial growth factor expression in hair follicle of C57BL/6 mice
5(2)
: 170~173
[journal]
이황희
/ 2005
/ 頭皮毛髮管理 및 脫毛의 臨床的 治療
/ 서울:圖書出版 靑藍
: 125~219
[journal]
/ 1996
/ Treatment of androgenetic alopecia with a 7.5% herbal preparation
7
: 159~162
[journal]
/ 1983
/ Topical MXD in the treatment of alopecia areata
: 1015~7
[journal]
/ 2005
/ Pharmacogenetic analysis of human steroid 5 alpha reductase type II: comparison of finasteride and dutasteride
34(3)
: 617~623
[journal]
/ 1999
/ Finasteride: a review of its use in male pattern hair loss
57(1)
: 111~126
[journal]
/ 2004
/ FINASTERIDE-ASSOCIATED MALE INFERTILITY
59(4)
: 203~205
[journal]
/ 1979
/ Hypertrichoasis due to MXD
[journal]
/ 2006
/ Finasteride-induced depression : A prospective study
6(1)
: 7~
[journal]
/ 2000
/ 脫毛證에 對한 桑白皮 複合物의 毛髮成長效果
42(2)
: 83~85
[journal]
/ 2002
/ 數種의 韓藥材가 脫髮成長에 미치는 影響
15(2)
: 80~103
[journal]
/ 2002
/ 苦蔘抽出物이 毛髮成長促進 및 面疱抑制에 미치는 影響
[journal]
/ 2003
/ 5種의 韓藥材抽出物이 脫毛防止와 毛髮成長促進에 미치는 實驗的 硏究
[journal]
/ 2004
/ 韓藥材 配合에 따른 脫毛防止 및 發毛促進에 關한 硏究
19(2)
: 9~20
[journal]
/ 2004
/ 5種의 韓藥抽出物이 含有된 헤어 에센스제품이 in vitro 및 in vivo에서 育毛 및 脫毛 防止에 미치는 效果
25(1)
: 152~160
[journal]
/ 2005
/ 生毛根이 脫毛에 미치는 臨床的 硏究
19(1)
: 270~278
[journal]
/ 1996.09
/ Bioactive constituents of Chinese natural medicines. I. New sesquiterpene ketones with vasorelaxant effect from Chinese moxa, the processed leaves of Artemisia argyi Levl. et Vant.: moxartenone and moxartenolide
44(9)
: 1656~1662
[journal]
/ Effective chemical constituents of Artemisia argyi Levl et Vant for inhibition of platelet aggregation
: 353~4
[journal]
/ 1999
/ (對譯)東醫寶鑑
/ 서울:法仁文化社
: 793~795
[journal]
/ 2001
/ 當歸類가 혈관신생에 미치는 영향에 대한 비교연구
16(2)
: 19~27
[journal]
/ 2006.01.01
/ Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer
66(1)
: 453~463
[journal]
/ 2003
/ the extract of Thujae occidentalis semen inhibited 5α-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse
31
: 91~98
[journal]
/ 2002
/ 탈모방지에 대한 고삼추출물 및 히노키티올 함유 제제의 임상효과
: 163~
[journal]
/ 1995
/ 本草綱目(校点本).
/ 北京:人民衛生出版社
: 846~
[journal]
/ 2006
/ Antioxidant activity of Punica granatum fruits
77(4)
: 310~312
[journal]
/ 2004
/ Study on wound healing activity of Punica granatum peel
7(2)
: 256~259
[journal]
/ 1990
/ Difference in activity of MXD and cyclosporin A on hair growth in nude and normal mice
[journal]
/ 1967
/ Studies of common baldness of the stump tailed macaque Distribution of the hair follicles
[journal]
/ 1974
/ Studies of common baldness in the stump-tailed macaque Regional difference of testosterone metabolites in the hair follicles
[journal]
/ 2003
/ Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages
12(6)
: 849~859
[journal]
/ 2001
/ Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells?
11
: 315~
[journal]
/ 2001.06.13-15
/ The effect of active compound
/ Third International Meeting of Hair Research Society
: 71~
[journal]
/ 1993
/ Effect of leaves of Ginkgo biloba on hair regrowth in C3H strain mouse
: 718~24
[journal]
/ 1988
/ Development studies drugs from natural resources Effects of crude drug extracts on hair growth in mice
: 971~8
[journal]
/ 1991
/ Quantitative models for the study of hair growth in vivo
[journal]
/ 1993
/ Upper hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential
[journal]
/ 1991
/ Human hair growth in vitro
[journal]
/ 1994
/ Stimulation of hair growth by topical application of FK506
/ a potent immunosuppressive agent
[journal]
/ 1994
/ The control of hair growth and pigmentation Disorders of Hair Growth
/ McGraw-Hill
[journal]
/ 1951
/ Critical stages of hair development and pigmentation in the mouse
[journal]
/ 1998
/ Do hair bulb melanocytes undergo apoptosis during hair follicle regression