Journal of Korean Medicine Rehabilitation 2023 KCI Impact Factor : 0.6
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pISSN : 1229-1854
- https://journal.kci.go.kr/jkmr
KJCKorea
Journal Central
Hair Growth Promoting Effect of Saengbal-eum(Sh？ngf？-y？n) Application on Hair-Removed C57BL/6 Mouse
- Journal of Korean Medicine Rehabilitation
- Abbr : JKMR
- 2007, 17(2), pp.101-121
- Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
- Research Area : Medicine and Pharmacy > Korean Medicine
이상학 1, Mi-Yeon Song 1, Chung, Seok Hee 1, SHIN HYUN DAE 1
1경희대학교
Candidate
ABSTRACT
Objectives :
Saengbal-eum(Shēngfà-yǐn) is a hair care product which is composed of eight plant extracts used in oriental medicine. This study was carried out to investigate effect of Saengbal-eum(Shēngfà-yǐn) on hair regrowth in a shaving model of C57BL6 mice.
Materials and Methods :
Five-week-old mice were acclimated for 1 week under 21~23℃, 40~60% relative humidity, and 12h of a light/dark cycle before beginning experiment. There were four experimental groups including normal saline(control), a positive control of 3% Minoxidil(MXD), and 30%, 100% Saengbal-eum(Shēngfà-yǐn) extracts(sample-I, II) for 12 female mice. The test compounds were topically treated once a day for 14 days. The hair regrowth was photographically and histologically determined during the experimental period of 14 days. Revelation of TGF-β1 and EGF were also determined using a immunohistochemistry.
Results :
The topical application of 3% MXD and Saengbal-eum(Shēngfà-yǐn) in female mice promoted hair regrowth earlier and faster than the control groups. Concentrations of hairs and thick-hair ratio in 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups were promoted than control group. There was not significant difference of hair regrowth, concentration of hair, and thick-hair ratio between 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups. TGF-β1 was not revealed in control, 3% MXD and Saengbal-eum(Shēngfà-yǐn) groups. EGF was strongly positive in out root sheat of some thick hair of 30%, 100% Saengbal-eum(Shēngfà-yǐn) group, but negative in control and 3% MXD group.
Conclusions :
These results suggest that Saengbal-eum(Shēngfà-yǐn) has hair growth promoting activity and it can be for treatment for alopecia. And these effects relate to EGF revelation of hair roots.
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