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@article{ART001267123},
author={송미영 and 김은경 and 공재철 and 이정한 and Ryu Do Gon and Kwon Kang-Beom and Shin, Byung Cheul},
title={Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2008},
volume={18},
number={3},
pages={41-49}

TY - JOUR
AU - 송미영
AU - 김은경
AU - 공재철
AU - 이정한
AU - Ryu Do Gon
AU - Kwon Kang-Beom
AU - Shin, Byung Cheul
TI - Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity
JO - Journal of Korean Medicine Rehabilitation
PY - 2008
VL - 18
IS - 3
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 41
EP - 49
SN - 1229-1854
AB - Objectives : The aim of this study is to investigate Daesiho-tang(Dachaihu-tang) water extracts (DSTE) have potent anti-obesity activities in a high-fat diet-induced obesity mouse model. Methods : In this study, we designed three groups (normal diet group, high-fat diet group, high-fat diet plus DSTE group for 7-weeks oral administration). Results : Increases in body weight were inhibited by 7-weeks oral administration of DSTE at a 500 mg/kg concentration in this animal model. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by DSTE administration, also HDL-cholesterol was increased more than high-fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of DSTE were examined on the expression of the genes involved in lipogenesis by real-time PCR. In epididymal fat and liver of DSTE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the tissues weight. Conclusions : These results suggest that DSTE may have great potential as a novel anti-obesity agent.
KW - Daesiho-tang(Dachaihu-tang);Obesity;High-fat diet;Sterol regulatory element binding protein 1;Fatty acid synthase
DO -
UR -
ER -

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom and Shin, Byung Cheul. (2008). Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity. Journal of Korean Medicine Rehabilitation, 18(3), 41-49.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom and Shin, Byung Cheul. 2008, "Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity", Journal of Korean Medicine Rehabilitation, vol.18, no.3 pp.41-49.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom, Shin, Byung Cheul "Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity" Journal of Korean Medicine Rehabilitation 18.3 pp.41-49 (2008) : 41.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom, Shin, Byung Cheul. Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity. 2008; 18(3), 41-49.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom and Shin, Byung Cheul. "Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity" Journal of Korean Medicine Rehabilitation 18, no.3 (2008) : 41-49.

송미영; 김은경; 공재철; 이정한; Ryu Do Gon; Kwon Kang-Beom; Shin, Byung Cheul. Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity. Journal of Korean Medicine Rehabilitation, 18(3), 41-49.

송미영; 김은경; 공재철; 이정한; Ryu Do Gon; Kwon Kang-Beom; Shin, Byung Cheul. Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity. Journal of Korean Medicine Rehabilitation. 2008; 18(3) 41-49.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom, Shin, Byung Cheul. Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity. 2008; 18(3), 41-49.

송미영, 김은경, 공재철, 이정한, Ryu Do Gon, Kwon Kang-Beom and Shin, Byung Cheul. "Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity" Journal of Korean Medicine Rehabilitation 18, no.3 (2008) : 41-49.