@article{ART001314076},
author={김남욱 and 조국령 and 임대웅 and 신용수 and 김진성 and choi jin bong and Sang-yoon Jeon and Hong Seok},
title={Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={1},
pages={1-9}
TY - JOUR
AU - 김남욱
AU - 조국령
AU - 임대웅
AU - 신용수
AU - 김진성
AU - choi jin bong
AU - Sang-yoon Jeon
AU - Hong Seok
TI - Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 1
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 1
EP - 9
SN - 1229-1854
AB - Objectives :
This study was designed to investigate the effects of Gleditsiae spina(GS) on changes in cerebral blood flow in rats.
Methods :
The present study was investigated regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in rats. In addtion, the present study also investigated action mechanisms of GS on changes in rCBF and MABP by Pre-treatment with indomethacin(IDM) and methylene blue(MTB), an inhibitor of a vasodepressor material.
Results :
Treatment with GS elevated rCBF in dose-dependent manner, but MABP levels were not affected by treatment with GS. Pre-treatment with indomethacin(IDM), an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. And pre-treatment with methylene blue(MTB), an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by GS too. In addition, Pre-treatment with MTB inhibited increase of MABP too. But, pre-treatment with IDM did not affect MABP levels.
Conclusions :
These results suggest that GS is effective to treat patient with disease related to cerebral ischemia, because GS can increase rCBF. In addition, the mechanisms are thought to be related to both of cyclooxygenase and guanylate cyclase pathways.
KW - Gleditsiae spina;Cerebral ischemia;rCBF;MABP
DO -
UR -
ER -
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon and Hong Seok. (2009). Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats. Journal of Korean Medicine Rehabilitation, 19(1), 1-9.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon and Hong Seok. 2009, "Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats", Journal of Korean Medicine Rehabilitation, vol.19, no.1 pp.1-9.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon, Hong Seok "Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats" Journal of Korean Medicine Rehabilitation 19.1 pp.1-9 (2009) : 1.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon, Hong Seok. Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats. 2009; 19(1), 1-9.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon and Hong Seok. "Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats" Journal of Korean Medicine Rehabilitation 19, no.1 (2009) : 1-9.
김남욱; 조국령; 임대웅; 신용수; 김진성; choi jin bong; Sang-yoon Jeon; Hong Seok. Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats. Journal of Korean Medicine Rehabilitation, 19(1), 1-9.
김남욱; 조국령; 임대웅; 신용수; 김진성; choi jin bong; Sang-yoon Jeon; Hong Seok. Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats. Journal of Korean Medicine Rehabilitation. 2009; 19(1) 1-9.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon, Hong Seok. Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats. 2009; 19(1), 1-9.
김남욱, 조국령, 임대웅, 신용수, 김진성, choi jin bong, Sang-yoon Jeon and Hong Seok. "Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats" Journal of Korean Medicine Rehabilitation 19, no.1 (2009) : 1-9.
