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Effects of Gleditsiae Spina(GS) Extract in Cerebral Blood Flow in Rats

  • Journal of Korean Medicine Rehabilitation
  • Abbr : JKMR
  • 2009, 19(1), pp.1-9
  • Publisher : The Korean Academy Of Oriental Rehabilitation Medicine
  • Research Area : Medicine and Pharmacy > Korean Medicine

김남욱 1 조국령 1 임대웅 1 신용수 1 김진성 1 choi jin bong 1 Sang-yoon Jeon 1 Hong Seok 1

1동신대학교

Accredited

ABSTRACT

Objectives : This study was designed to investigate the effects of Gleditsiae spina(GS) on changes in cerebral blood flow in rats. Methods : The present study was investigated regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in rats. In addtion, the present study also investigated action mechanisms of GS on changes in rCBF and MABP by Pre-treatment with indomethacin(IDM) and methylene blue(MTB), an inhibitor of a vasodepressor material. Results : Treatment with GS elevated rCBF in dose-dependent manner, but MABP levels were not affected by treatment with GS. Pre-treatment with indomethacin(IDM), an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively. And pre-treatment with methylene blue(MTB), an inhibitor of guanylate cyclase, inhibited increase of rCBF induced by GS too. In addition, Pre-treatment with MTB inhibited increase of MABP too. But, pre-treatment with IDM did not affect MABP levels. Conclusions : These results suggest that GS is effective to treat patient with disease related to cerebral ischemia, because GS can increase rCBF. In addition, the mechanisms are thought to be related to both of cyclooxygenase and guanylate cyclase pathways.

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