@article{ART001339411},
author={정문재 and 이정한 and Seung-ryong Yeom and LEE SU KYUNG and SONG YUNG SUN and 김기병 and Young Dal Kwon},
title={Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve},
journal={Journal of Korean Medicine Rehabilitation},
issn={1229-1854},
year={2009},
volume={19},
number={2},
pages={51-72}
TY - JOUR
AU - 정문재
AU - 이정한
AU - Seung-ryong Yeom
AU - LEE SU KYUNG
AU - SONG YUNG SUN
AU - 김기병
AU - Young Dal Kwon
TI - Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve
JO - Journal of Korean Medicine Rehabilitation
PY - 2009
VL - 19
IS - 2
PB - The Korean Academy Of Oriental Rehabilitation Medicine
SP - 51
EP - 72
SN - 1229-1854
AB - Objectives :
This study was designed to evaluate the effects of Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture on pain reduction and nerve regeneration after crush injury in rat sciatic nerve.
Methods :
Animal model was produced through crush injury of right sciatic nerve and they were divided into four groups; Group I: no treatment control group; Group II: experimental group treated with Ohyaksungi-san(Wuyaoshungi-san); Group III: experimental group treated with Jungsongouhyul pharmacopuncture; Group IV: experimental group treated with Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture. For the assessment of pain, this study was observed the paw withdrawal latency(PWL) and immunoreactivity on the substance-P. For the assessment of nerve regeneration, the sciatic functional index(SFI) and immunoreactivity on the BDNF were measured.
Results :
1. In the assessment of pain, the PWL of experimental groups was significantly higher than control group and group IV was significantly higher than other groups at the all days.
2. In immunohistochemical response of substance-P, as time passes, the immunoreactivity of all groups were decreased gradully. Especially, group IV had the lowest immunoreactivity.
3. In the assessment of SFI, the SFI of experimental groups were significantly higher than control group.
4. In immunohistochemical response of BDNF, the BDNF immunoreactivity of all groups was significantly higher than control group and especially, group IV had the highest immunoreactivity at the 14 days after injury.
5. H & E stain was used on the liver and kidney to investigate toxic effect of Jungsongouhyul pharmacopuncture and Ohyaksungi-san(Wuyaoshungi-san) on on 21 days after injury. However there were no any toxic effects both control group and experimental groups.
Conclusions :
On the basis of these results, we propose that Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture were related to pain reduction and motor nerve recovery, also decreased substance-P expression and increased BDNF expression after crush injury of sciatic nerve, especially these two treatments could be more effective when they were combined simultaneously.
KW - Ohyaksungi-san(Wuyaoshungi-san);Jungsongouhyul pharmacopuncture;Pain reduction;Nerve regeneration;PWL;Substance-P;SFI;BDNF
DO -
UR -
ER -
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병 and Young Dal Kwon. (2009). Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. Journal of Korean Medicine Rehabilitation, 19(2), 51-72.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병 and Young Dal Kwon. 2009, "Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve", Journal of Korean Medicine Rehabilitation, vol.19, no.2 pp.51-72.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병, Young Dal Kwon "Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve" Journal of Korean Medicine Rehabilitation 19.2 pp.51-72 (2009) : 51.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병, Young Dal Kwon. Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. 2009; 19(2), 51-72.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병 and Young Dal Kwon. "Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve" Journal of Korean Medicine Rehabilitation 19, no.2 (2009) : 51-72.
정문재; 이정한; Seung-ryong Yeom; LEE SU KYUNG; SONG YUNG SUN; 김기병; Young Dal Kwon. Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. Journal of Korean Medicine Rehabilitation, 19(2), 51-72.
정문재; 이정한; Seung-ryong Yeom; LEE SU KYUNG; SONG YUNG SUN; 김기병; Young Dal Kwon. Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. Journal of Korean Medicine Rehabilitation. 2009; 19(2) 51-72.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병, Young Dal Kwon. Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve. 2009; 19(2), 51-72.
정문재, 이정한, Seung-ryong Yeom, LEE SU KYUNG, SONG YUNG SUN, 김기병 and Young Dal Kwon. "Effects of Ohyaksungi-san(Wuyaoshungi-san )and Jungsongouhyul Pharmacopuncture on Pain Reduction and Nerve Regeneration after Crush Injury in Rat Sciatic Nerve" Journal of Korean Medicine Rehabilitation 19, no.2 (2009) : 51-72.